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Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations.
Vet J. 2019 Jan; 243:8-14.VJ

Abstract

The objective of this study was to compare the effects of parenteral (PE) versus oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six dogs with serum cobalamin concentrations below 285ng/L (reference interval (RI): 244-959ng/L) were treated with PO (0.25-1.0mg daily) or PE cobalamin (0.25-1.2mg/injection) using a block-randomized schedule. Serum MMA and HCY concentrations were analysed at day 0, 28 and 90 after start of supplementation. There was no significant difference between the PO and PE group regarding serum MMA or HCY concentrations at any time point. Median (range, P comparing baseline and 28 days, P comparing 28days and 90 days) serum MMA concentrations (nmol/L; RI 415-1193) were 932 (566-2468) in the PO and 943 (508-1900) in the PE group at baseline, respectively, 705 (386-1465, P<0.0001) and 696 (377-932, P<0.0001) after 28 days, and 739 (450-1221, P=0.58) and 690 (349-1145, P=0.76) after 90 days. Serum HCY concentrations (median (range), P comparing baseline and 28 days, P comparing 28days and 90 days, μmol/L; RI 5.9-31.9) in the PO and PE groups were 12.2 (3.3-62.2) and 8.4 (3.7-34.8) at baseline, 12.5 (5.0-45.0, P=0.61) and 8.0 (3.8-18.3, P=0.28) after 28 days, and 17.7 (7.3-60.0 P=0.07) and 12.4 (6.3-33.1, P=0.0007) after 90 days, respectively. Oral and parenteral cobalamin supplementation had the same effect on serum MMA concentrations in this group of dogs.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Toresson L
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, Helsinki University, Agnes Sjobergin katu 2, 00014 Helsinki, Finland; Evidensia Specialist Animal Hospital, Bergavagen 3, 25466 Helsingborg, Sweden. Electronic address: linda.toresson@evidensia.se.
Steiner JM
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, 4474 TAMU, College Station, TX 77843-4474, USA.
Spodsberg E
Evidensia Specialist Animal Hospital, Bergavagen 3, 25466 Helsingborg, Sweden.
Olmedal G
Evidensia Specialist Animal Hospital, Bergavagen 3, 25466 Helsingborg, Sweden.
Suchodolski JS
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, 4474 TAMU, College Station, TX 77843-4474, USA.
Lidbury JA
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, 4474 TAMU, College Station, TX 77843-4474, USA.
Spillmann T
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, Helsinki University, Agnes Sjobergin katu 2, 00014 Helsinki, Finland.

MeSH

Administration, OralAnimalsDietary SupplementsDog DiseasesDogsFemaleHomocysteineInfusions, ParenteralIntestinal DiseasesMaleMethylmalonic AcidProspective StudiesRandom AllocationVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Clinical Trial, Veterinary
Comparative Study
Journal Article

Language

eng

PubMed ID

30606444

Citation

Toresson, L, et al. "Effects of Oral Versus Parenteral Cobalamin Supplementation On Methylmalonic Acid and Homocysteine Concentrations in Dogs With Chronic Enteropathies and Low Cobalamin Concentrations." Veterinary Journal (London, England : 1997), vol. 243, 2019, pp. 8-14.
Toresson L, Steiner JM, Spodsberg E, et al. Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations. Vet J. 2019;243:8-14.
Toresson, L., Steiner, J. M., Spodsberg, E., Olmedal, G., Suchodolski, J. S., Lidbury, J. A., & Spillmann, T. (2019). Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations. Veterinary Journal (London, England : 1997), 243, 8-14. https://doi.org/10.1016/j.tvjl.2018.11.004
Toresson L, et al. Effects of Oral Versus Parenteral Cobalamin Supplementation On Methylmalonic Acid and Homocysteine Concentrations in Dogs With Chronic Enteropathies and Low Cobalamin Concentrations. Vet J. 2019;243:8-14. PubMed PMID: 30606444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations. AU - Toresson,L, AU - Steiner,J M, AU - Spodsberg,E, AU - Olmedal,G, AU - Suchodolski,J S, AU - Lidbury,J A, AU - Spillmann,T, Y1 - 2018/11/12/ PY - 2018/05/15/received PY - 2018/11/05/revised PY - 2018/11/07/accepted PY - 2019/1/5/entrez PY - 2019/1/5/pubmed PY - 2019/1/15/medline KW - Chronic enteropathy KW - Dog KW - Inflammatory bowel disease KW - Oral supplementation KW - Vitamin B12 SP - 8 EP - 14 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 243 N2 - The objective of this study was to compare the effects of parenteral (PE) versus oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six dogs with serum cobalamin concentrations below 285ng/L (reference interval (RI): 244-959ng/L) were treated with PO (0.25-1.0mg daily) or PE cobalamin (0.25-1.2mg/injection) using a block-randomized schedule. Serum MMA and HCY concentrations were analysed at day 0, 28 and 90 after start of supplementation. There was no significant difference between the PO and PE group regarding serum MMA or HCY concentrations at any time point. Median (range, P comparing baseline and 28 days, P comparing 28days and 90 days) serum MMA concentrations (nmol/L; RI 415-1193) were 932 (566-2468) in the PO and 943 (508-1900) in the PE group at baseline, respectively, 705 (386-1465, P<0.0001) and 696 (377-932, P<0.0001) after 28 days, and 739 (450-1221, P=0.58) and 690 (349-1145, P=0.76) after 90 days. Serum HCY concentrations (median (range), P comparing baseline and 28 days, P comparing 28days and 90 days, μmol/L; RI 5.9-31.9) in the PO and PE groups were 12.2 (3.3-62.2) and 8.4 (3.7-34.8) at baseline, 12.5 (5.0-45.0, P=0.61) and 8.0 (3.8-18.3, P=0.28) after 28 days, and 17.7 (7.3-60.0 P=0.07) and 12.4 (6.3-33.1, P=0.0007) after 90 days, respectively. Oral and parenteral cobalamin supplementation had the same effect on serum MMA concentrations in this group of dogs. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/30606444/Effects_of_oral_versus_parenteral_cobalamin_supplementation_on_methylmalonic_acid_and_homocysteine_concentrations_in_dogs_with_chronic_enteropathies_and_low_cobalamin_concentrations_ DB - PRIME DP - Unbound Medicine ER -