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Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson's disease.
J Neurol. 2019 Mar; 266(3):636-641.JN

Abstract

Excessive daytime sleepiness (EDS) may represent a disabling non-motor symptom in patients affected by Parkinson's disease (PD). This is a secondary analysis of a previous study documenting the improvement of nocturnal sleep in PD patients treated by rotigotine vs placebo. Here we tested the supposition that EDS may represent a distinct PD non-motor symptom occurring independently of other sleep-wake disorders; moreover, we verified whether EDS can be influenced by the improvement of nocturnal sleep in PD. In the present study, we evaluated the daytime sleepiness of PD patients treated with nocturnal administration of rotigotine (PD-Rot) vs placebo (PD-Pla), as measured by both subjective (Epworth Sleepiness Scale-ESS) and objective (Multiple Sleep Latency Test-MSLT) tools. We included 21 PD-Rot compared to 21 PD-Pla patients and documented no significant changes of both ESS and MSLT data between baseline and follow-up visits in both groups. Moreover, we found no correlations between nocturnal sleep improvement and diurnal sleepiness. Therefore, these data suggest that the improvement of nocturnal sleep in PD patients does not modify the daytime sleepiness, thus suggesting that diurnal sleepiness may occur independently of nocturnal sleep disturbances in PD patients.

Authors+Show Affiliations

Department of Systems Medicine, Sleep Medicine Centre, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy. dott.claudioliguori@yahoo.it. UOSD Parkinson, University Hospital of Rome "Tor Vergata", Rome, Italy. dott.claudioliguori@yahoo.it. Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. dott.claudioliguori@yahoo.it.Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. Fondazione Santa Lucia IRCCS, Rome, Italy.Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.Parkinson and Movement Disorders Unit, Neurology Department, IRCCS Neuromed, Pozzilli, IS, Italy.UOSD Parkinson, University Hospital of Rome "Tor Vergata", Rome, Italy. Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.UOSD Parkinson, University Hospital of Rome "Tor Vergata", Rome, Italy. Neurology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

30607535

Citation

Liguori, Claudio, et al. "Daytime Sleepiness May Be an Independent Symptom Unrelated to Sleep Quality in Parkinson's Disease." Journal of Neurology, vol. 266, no. 3, 2019, pp. 636-641.
Liguori C, Mercuri NB, Albanese M, et al. Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson's disease. J Neurol. 2019;266(3):636-641.
Liguori, C., Mercuri, N. B., Albanese, M., Olivola, E., Stefani, A., & Pierantozzi, M. (2019). Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson's disease. Journal of Neurology, 266(3), 636-641. https://doi.org/10.1007/s00415-018-09179-8
Liguori C, et al. Daytime Sleepiness May Be an Independent Symptom Unrelated to Sleep Quality in Parkinson's Disease. J Neurol. 2019;266(3):636-641. PubMed PMID: 30607535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson's disease. AU - Liguori,Claudio, AU - Mercuri,Nicola Biagio, AU - Albanese,Maria, AU - Olivola,Enrica, AU - Stefani,Alessandro, AU - Pierantozzi,Mariangela, Y1 - 2019/01/03/ PY - 2018/11/14/received PY - 2018/12/31/accepted PY - 2018/12/28/revised PY - 2019/1/5/pubmed PY - 2019/6/7/medline PY - 2019/1/5/entrez KW - ESS KW - Excessive daytime sleepiness KW - MSLT KW - Parkinson’s disease KW - Rotigotine KW - Sleep-wake cycle SP - 636 EP - 641 JF - Journal of neurology JO - J Neurol VL - 266 IS - 3 N2 - Excessive daytime sleepiness (EDS) may represent a disabling non-motor symptom in patients affected by Parkinson's disease (PD). This is a secondary analysis of a previous study documenting the improvement of nocturnal sleep in PD patients treated by rotigotine vs placebo. Here we tested the supposition that EDS may represent a distinct PD non-motor symptom occurring independently of other sleep-wake disorders; moreover, we verified whether EDS can be influenced by the improvement of nocturnal sleep in PD. In the present study, we evaluated the daytime sleepiness of PD patients treated with nocturnal administration of rotigotine (PD-Rot) vs placebo (PD-Pla), as measured by both subjective (Epworth Sleepiness Scale-ESS) and objective (Multiple Sleep Latency Test-MSLT) tools. We included 21 PD-Rot compared to 21 PD-Pla patients and documented no significant changes of both ESS and MSLT data between baseline and follow-up visits in both groups. Moreover, we found no correlations between nocturnal sleep improvement and diurnal sleepiness. Therefore, these data suggest that the improvement of nocturnal sleep in PD patients does not modify the daytime sleepiness, thus suggesting that diurnal sleepiness may occur independently of nocturnal sleep disturbances in PD patients. SN - 1432-1459 UR - https://www.unboundmedicine.com/medline/citation/30607535/Daytime_sleepiness_may_be_an_independent_symptom_unrelated_to_sleep_quality_in_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s00415-018-09179-8 DB - PRIME DP - Unbound Medicine ER -