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Evaluation of 13 rapidly mutating Y-STRs in endogamous Punjabi and Sindhi ethnic groups from Pakistan.
Int J Legal Med. 2019 May; 133(3):799-802.IJ

Abstract

Y-chromosomal short tandem repeats (Y-STRs) are commonly used to study population histories, discover ancestral relationships, and identify males for criminal justice purposes. Y-STRs being largely in forensic use have low haplotype diversity in some populations and cannot discriminate between paternal male relatives. Rapidly mutating Y-STRs (RM Y-STRs) were breakthrough and have been paid much attention. A set of 13 rapidly mutating (RM) Y-STRs (DYF387S1, DYF399S1, DYF403S1a/b1/b2, DYF404S1, DYS449, DYS518, DYS526I/II, DYS547, DYS570, DYS576, DYS612, DYS626, and DYS627) typically reveals higher haplotype diversities than the commercially available Y-STR sets and allows differentiating male relatives for which commercial Y-STR sets are usually not informative. Here, we amplified the 13 RM Y-STRs in 168 (37 Sindhi and 131 Punjabi) individuals from Pakistani population, which is characterized by high rates of endogamy. The haplotype diversity and discrimination capacity were 1. Allelic frequencies ranged from 0.0060 to 0.5060, while gene diversity ranged from 0.6759 (DYS526a) to 0.9937 (DYF399S1). A total 319 different alleles were observed. Results of our study showed that RM Y-STRs provided substantially stronger discriminatory power in Pakistani populations.

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Authors+Show Affiliations

Adnan A
Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, 110122, People's Republic of China. mirzaatifadnan@gmail.com.
Rakha A
Department of Forensic Sciences, University of Health Sciences Lahore, Lahore, 54000, Pakistan.
Nazir S
Department of Forensic Sciences, University of Health Sciences Lahore, Lahore, 54000, Pakistan.
Khan MF
Department of Forensic Sciences, University of Health Sciences Lahore, Lahore, 54000, Pakistan.
Hadi S
School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, UK.
Xuan J
Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, 110122, People's Republic of China. jfxuan@cmu.edu.cn.

MeSH

Chromosomes, Human, YDNA FingerprintingEthnicityGene FrequencyGenetic VariationGenetics, PopulationHaplotypesHumansMaleMicrosatellite RepeatsPakistan

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30610450

Citation

Adnan, Atif, et al. "Evaluation of 13 Rapidly Mutating Y-STRs in Endogamous Punjabi and Sindhi Ethnic Groups From Pakistan." International Journal of Legal Medicine, vol. 133, no. 3, 2019, pp. 799-802.
Adnan A, Rakha A, Nazir S, et al. Evaluation of 13 rapidly mutating Y-STRs in endogamous Punjabi and Sindhi ethnic groups from Pakistan. Int J Legal Med. 2019;133(3):799-802.
Adnan, A., Rakha, A., Nazir, S., Khan, M. F., Hadi, S., & Xuan, J. (2019). Evaluation of 13 rapidly mutating Y-STRs in endogamous Punjabi and Sindhi ethnic groups from Pakistan. International Journal of Legal Medicine, 133(3), 799-802. https://doi.org/10.1007/s00414-018-01997-9
Adnan A, et al. Evaluation of 13 Rapidly Mutating Y-STRs in Endogamous Punjabi and Sindhi Ethnic Groups From Pakistan. Int J Legal Med. 2019;133(3):799-802. PubMed PMID: 30610450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of 13 rapidly mutating Y-STRs in endogamous Punjabi and Sindhi ethnic groups from Pakistan. AU - Adnan,Atif, AU - Rakha,Allah, AU - Nazir,Shahid, AU - Khan,Muhammad Farhan, AU - Hadi,Sibte, AU - Xuan,Jinfeng, Y1 - 2019/01/04/ PY - 2018/11/11/received PY - 2018/12/19/accepted PY - 2019/1/6/pubmed PY - 2019/5/30/medline PY - 2019/1/6/entrez KW - Endogamous KW - Pakistan KW - Paternal lineage KW - Punjabi KW - RM Y-STRs KW - Sindhi SP - 799 EP - 802 JF - International journal of legal medicine JO - Int J Legal Med VL - 133 IS - 3 N2 - Y-chromosomal short tandem repeats (Y-STRs) are commonly used to study population histories, discover ancestral relationships, and identify males for criminal justice purposes. Y-STRs being largely in forensic use have low haplotype diversity in some populations and cannot discriminate between paternal male relatives. Rapidly mutating Y-STRs (RM Y-STRs) were breakthrough and have been paid much attention. A set of 13 rapidly mutating (RM) Y-STRs (DYF387S1, DYF399S1, DYF403S1a/b1/b2, DYF404S1, DYS449, DYS518, DYS526I/II, DYS547, DYS570, DYS576, DYS612, DYS626, and DYS627) typically reveals higher haplotype diversities than the commercially available Y-STR sets and allows differentiating male relatives for which commercial Y-STR sets are usually not informative. Here, we amplified the 13 RM Y-STRs in 168 (37 Sindhi and 131 Punjabi) individuals from Pakistani population, which is characterized by high rates of endogamy. The haplotype diversity and discrimination capacity were 1. Allelic frequencies ranged from 0.0060 to 0.5060, while gene diversity ranged from 0.6759 (DYS526a) to 0.9937 (DYF399S1). A total 319 different alleles were observed. Results of our study showed that RM Y-STRs provided substantially stronger discriminatory power in Pakistani populations. SN - 1437-1596 UR - https://www.unboundmedicine.com/medline/citation/30610450/Evaluation_of_13_rapidly_mutating_Y_STRs_in_endogamous_Punjabi_and_Sindhi_ethnic_groups_from_Pakistan_ DB - PRIME DP - Unbound Medicine ER -