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Alcohol use and dementia: a systematic scoping review.
Alzheimers Res Ther. 2019 01 05; 11(1):1.AR

Abstract

BACKGROUND

Alcohol use has been identified as a risk factor for dementia and cognitive decline. However, some patterns of drinking have been associated with beneficial effects.

METHODS AND RESULTS

To clarify the relationship between alcohol use and dementia, we conducted a scoping review based on a systematic search of systematic reviews published from January 2000 to October 2017 by using Medline, Embase, and PsycINFO. Overall, 28 systematic reviews were identified: 20 on the associations between the level of alcohol use and the incidence of cognitive impairment/dementia, six on the associations between dimensions of alcohol use and specific brain functions, and two on induced dementias. Although causality could not be established, light to moderate alcohol use in middle to late adulthood was associated with a decreased risk of cognitive impairment and dementia. Heavy alcohol use was associated with changes in brain structures, cognitive impairments, and an increased risk of all types of dementia.

CONCLUSION

Reducing heavy alcohol use may be an effective dementia prevention strategy.

Links

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Authors+Show Affiliations

Rehm J
Institute for Mental Health Policy Research, CAMH, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada. jtrehm@gmail.com. Dalla Lana School of Public Health, University of Toronto, 27 King's College Circle, Toronto, M5S 1A1, Ontario, Canada. jtrehm@gmail.com. Campbell Family Mental Health Research Institute, CAMH, 250 College Street, Toronto, M5T 1R8, Ontario, Canada. jtrehm@gmail.com. Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, M5S 1A8, Ontario, Canada. jtrehm@gmail.com. Department of Psychiatry, University of Toronto, 250 College Street, Toronto, M5T 1R8, Ontario, Canada. jtrehm@gmail.com. Institute for Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46, Dresden, 01187, Germany. jtrehm@gmail.com.
Hasan OSM
Institute for Mental Health Policy Research, CAMH, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada. Dalla Lana School of Public Health, University of Toronto, 27 King's College Circle, Toronto, M5S 1A1, Ontario, Canada.
Black SE
Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, M5S 1A8, Ontario, Canada. Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, 2075 Bayview Avenue, Toronto, M4N 3M5, Ontario, Canada. Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, M4N 3M5, Ontario, Canada.
Shield KD
Institute for Mental Health Policy Research, CAMH, 33 Russell Street, Toronto, Ontario, M5S 2S1, Canada. Dalla Lana School of Public Health, University of Toronto, 27 King's College Circle, Toronto, M5S 1A1, Ontario, Canada.
Schwarzinger M
Translational Health Economics Network (THEN), 39 quai de Valmy, Paris, 75010 Paris, France.

MeSH

Alcohol DrinkingBrainCognitive DysfunctionDementiaHumansMeta-Analysis as TopicSystematic Reviews as Topic

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

30611304

Citation

Rehm, Jürgen, et al. "Alcohol Use and Dementia: a Systematic Scoping Review." Alzheimer's Research & Therapy, vol. 11, no. 1, 2019, p. 1.
Rehm J, Hasan OSM, Black SE, et al. Alcohol use and dementia: a systematic scoping review. Alzheimers Res Ther. 2019;11(1):1.
Rehm, J., Hasan, O. S. M., Black, S. E., Shield, K. D., & Schwarzinger, M. (2019). Alcohol use and dementia: a systematic scoping review. Alzheimer's Research & Therapy, 11(1), 1. https://doi.org/10.1186/s13195-018-0453-0
Rehm J, et al. Alcohol Use and Dementia: a Systematic Scoping Review. Alzheimers Res Ther. 2019 01 5;11(1):1. PubMed PMID: 30611304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol use and dementia: a systematic scoping review. AU - Rehm,Jürgen, AU - Hasan,Omer S M, AU - Black,Sandra E, AU - Shield,Kevin D, AU - Schwarzinger,Michaël, Y1 - 2019/01/05/ PY - 2019/1/7/entrez PY - 2019/1/7/pubmed PY - 2020/3/31/medline KW - Alcohol KW - Alzheimer’s disease KW - Brain function KW - Brain volumetrics KW - Cognition KW - Dementia KW - Risk KW - Systematic review KW - Vascular dementia SP - 1 EP - 1 JF - Alzheimer's research & therapy JO - Alzheimers Res Ther VL - 11 IS - 1 N2 - BACKGROUND: Alcohol use has been identified as a risk factor for dementia and cognitive decline. However, some patterns of drinking have been associated with beneficial effects. METHODS AND RESULTS: To clarify the relationship between alcohol use and dementia, we conducted a scoping review based on a systematic search of systematic reviews published from January 2000 to October 2017 by using Medline, Embase, and PsycINFO. Overall, 28 systematic reviews were identified: 20 on the associations between the level of alcohol use and the incidence of cognitive impairment/dementia, six on the associations between dimensions of alcohol use and specific brain functions, and two on induced dementias. Although causality could not be established, light to moderate alcohol use in middle to late adulthood was associated with a decreased risk of cognitive impairment and dementia. Heavy alcohol use was associated with changes in brain structures, cognitive impairments, and an increased risk of all types of dementia. CONCLUSION: Reducing heavy alcohol use may be an effective dementia prevention strategy. SN - 1758-9193 UR - https://www.unboundmedicine.com/medline/citation/30611304/Alcohol_use_and_dementia:_a_systematic_scoping_review_ DB - PRIME DP - Unbound Medicine ER -