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Diagnosis and Treatment of Peptic Ulcer Disease.
Am J Med. 2019 04; 132(4):447-456.AJ

Abstract

Peptic ulcer disease continues to be a source of significant morbidity and mortality worldwide. Approximately two-thirds of patients found to have peptic ulcer disease are asymptomatic. In symptomatic patients, the most common presenting symptom of peptic ulcer disease is epigastric pain, which may be associated with dyspepsia, bloating, abdominal fullness, nausea, or early satiety. Most cases of peptic ulcer disease are associated with Helicobacter pylori infection or the use of nonsteroidal anti-inflammatory drugs (NSAIDs), or both. In this review, we discuss the role of proton pump inhibitors in the management of peptic ulcer disease, highlight the latest guidelines about the diagnosis and management of H. pylori, and discuss the latest evidence in the management of complications related to peptic ulcer disease, including endoscopic intervention for peptic ulcer-related bleeding. Timely diagnosis and treatment of peptic ulcer disease and its sequelae are crucial in order to minimize associated morbidity and mortality, as is prevention of peptic ulcer disease among patients at high risk, including those infected with H. pylori and users of NSAIDs.

Authors+Show Affiliations

Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Ill.Division of Gastroenterology and Hepatology, University of Illinois at Chicago.Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Ill.Institute of Gastroenterology, Hepatology, and Nutrition, Emek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address: ian_gr@clalit.org.il.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30611829

Citation

Kavitt, Robert T., et al. "Diagnosis and Treatment of Peptic Ulcer Disease." The American Journal of Medicine, vol. 132, no. 4, 2019, pp. 447-456.
Kavitt RT, Lipowska AM, Anyane-Yeboa A, et al. Diagnosis and Treatment of Peptic Ulcer Disease. Am J Med. 2019;132(4):447-456.
Kavitt, R. T., Lipowska, A. M., Anyane-Yeboa, A., & Gralnek, I. M. (2019). Diagnosis and Treatment of Peptic Ulcer Disease. The American Journal of Medicine, 132(4), 447-456. https://doi.org/10.1016/j.amjmed.2018.12.009
Kavitt RT, et al. Diagnosis and Treatment of Peptic Ulcer Disease. Am J Med. 2019;132(4):447-456. PubMed PMID: 30611829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and Treatment of Peptic Ulcer Disease. AU - Kavitt,Robert T, AU - Lipowska,Anna M, AU - Anyane-Yeboa,Adjoa, AU - Gralnek,Ian M, Y1 - 2019/01/03/ PY - 2018/11/24/received PY - 2018/12/17/revised PY - 2018/12/17/accepted PY - 2019/1/7/pubmed PY - 2019/12/28/medline PY - 2019/1/7/entrez KW - Helicobacter pylori KW - Peptic ulcer disease SP - 447 EP - 456 JF - The American journal of medicine JO - Am J Med VL - 132 IS - 4 N2 - Peptic ulcer disease continues to be a source of significant morbidity and mortality worldwide. Approximately two-thirds of patients found to have peptic ulcer disease are asymptomatic. In symptomatic patients, the most common presenting symptom of peptic ulcer disease is epigastric pain, which may be associated with dyspepsia, bloating, abdominal fullness, nausea, or early satiety. Most cases of peptic ulcer disease are associated with Helicobacter pylori infection or the use of nonsteroidal anti-inflammatory drugs (NSAIDs), or both. In this review, we discuss the role of proton pump inhibitors in the management of peptic ulcer disease, highlight the latest guidelines about the diagnosis and management of H. pylori, and discuss the latest evidence in the management of complications related to peptic ulcer disease, including endoscopic intervention for peptic ulcer-related bleeding. Timely diagnosis and treatment of peptic ulcer disease and its sequelae are crucial in order to minimize associated morbidity and mortality, as is prevention of peptic ulcer disease among patients at high risk, including those infected with H. pylori and users of NSAIDs. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/30611829/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(19)30004-X DB - PRIME DP - Unbound Medicine ER -