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Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents.
Chest. 2019 01; 155(1):94-102.Chest

Abstract

BACKGROUND

Glutathione S-transferase (GST) genes are involved in the management of oxidative stress in the lungs. We aimed to determine whether they modify the associations between early life smoke exposure and adverse lung health outcomes.

METHODS

The Melbourne Atopy Cohort study (a high-risk birth cohort) enrolled 620 children and followed them prospectively from birth. We recorded perinatal tobacco smoke exposure, asthma, and lung function at 12 (59%) and 18 years (66%) and genotyped for GSTM1, GSTT1, and GSTP1 (69%).

RESULTS

GST genotypes were found to interact with tobacco smoke exposure on lung function outcomes (P interaction ≤ .05). Only among children with GSTT1 null genotypes was exposure to mother's, father's, or parental tobacco smoke in early life associated with an increased risk of reductions in prebronchodilator (BD) FEV1 and FVC at both 12 and 18 years. These associations were not seen in children with GSTT1 present. Similarly, only among children with GSTM1 null genotypes was exposure to father's or parental smoking associated with reductions in pre- and post-BD FEV1 and FVC at 18 years. Only among children with Ile/Ile genotypes of GSTP1 was exposure to mother's smoking associated with increased risk of reduced FEV1 at 18 years, but this was not the case among children with Val/Val or Ile/Val genotypes.

CONCLUSIONS

Our study provides evidence of interaction between early tobacco smoke exposure and GST genotypes on lung function. Carriers of GST null mutations and GSTP1 Ile/Ile alleles may be more susceptible when exposed to tobacco smoke in early life. These findings support stronger recommendations to protect all infants from tobacco smoke exposure.

TRIAL REGISTRY

Australian and New Zealand Clinical Trials Registry; No.: ACTRN12609000734268; URL: http://www.anzctr.org.au/.

Authors+Show Affiliations

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Centre for Food and Allergy Research, Murdoch Children's Research Institute, Parkville, VIC, Australia. Electronic address: s.dharmage@unimelb.edu.au.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; National Institute of Fundamental Studies, Kandy, Sri Lanka.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.PathWest Laboratory Medicine of West Australia, Perth, WA, Australia; School of Population and Global Health and School of Pathology and Laboratory Medicine, The University of Western Australia, WA, Australia; Busselton Population Medical Research Institute, WA, Australia.School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia; Centre for International Health, University of Bergen, Bergen, Norway.School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC, Australia.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Centre for Food and Allergy Research, Murdoch Children's Research Institute, Parkville, VIC, Australia.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30616740

Citation

Dai, Xin, et al. "Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure On Lung Function in Adolescents." Chest, vol. 155, no. 1, 2019, pp. 94-102.
Dai X, Dharmage SC, Bowatte G, et al. Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents. Chest. 2019;155(1):94-102.
Dai, X., Dharmage, S. C., Bowatte, G., Waidyatillake, N. T., Perret, J. L., Hui, J., Erbas, B., Abramson, M. J., Lowe, A. J., Burgess, J. A., Svanes, C., & Lodge, C. J. (2019). Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents. Chest, 155(1), 94-102. https://doi.org/10.1016/j.chest.2018.08.1079
Dai X, et al. Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure On Lung Function in Adolescents. Chest. 2019;155(1):94-102. PubMed PMID: 30616740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents. AU - Dai,Xin, AU - Dharmage,Shyamali C, AU - Bowatte,Gayan, AU - Waidyatillake,Nilakshi T, AU - Perret,Jennifer L, AU - Hui,Jennie, AU - Erbas,Bircan, AU - Abramson,Michael J, AU - Lowe,Adrian J, AU - Burgess,John A, AU - Svanes,Cecilie, AU - Lodge,Caroline J, PY - 2018/03/13/received PY - 2018/07/14/revised PY - 2018/08/24/accepted PY - 2019/1/9/entrez PY - 2019/1/9/pubmed PY - 2019/10/12/medline KW - epidemiology (pulmonary) KW - gene polymorphism KW - lung function KW - pediatric asthma KW - tobacco smoke exposure SP - 94 EP - 102 JF - Chest JO - Chest VL - 155 IS - 1 N2 - BACKGROUND: Glutathione S-transferase (GST) genes are involved in the management of oxidative stress in the lungs. We aimed to determine whether they modify the associations between early life smoke exposure and adverse lung health outcomes. METHODS: The Melbourne Atopy Cohort study (a high-risk birth cohort) enrolled 620 children and followed them prospectively from birth. We recorded perinatal tobacco smoke exposure, asthma, and lung function at 12 (59%) and 18 years (66%) and genotyped for GSTM1, GSTT1, and GSTP1 (69%). RESULTS: GST genotypes were found to interact with tobacco smoke exposure on lung function outcomes (P interaction ≤ .05). Only among children with GSTT1 null genotypes was exposure to mother's, father's, or parental tobacco smoke in early life associated with an increased risk of reductions in prebronchodilator (BD) FEV1 and FVC at both 12 and 18 years. These associations were not seen in children with GSTT1 present. Similarly, only among children with GSTM1 null genotypes was exposure to father's or parental smoking associated with reductions in pre- and post-BD FEV1 and FVC at 18 years. Only among children with Ile/Ile genotypes of GSTP1 was exposure to mother's smoking associated with increased risk of reduced FEV1 at 18 years, but this was not the case among children with Val/Val or Ile/Val genotypes. CONCLUSIONS: Our study provides evidence of interaction between early tobacco smoke exposure and GST genotypes on lung function. Carriers of GST null mutations and GSTP1 Ile/Ile alleles may be more susceptible when exposed to tobacco smoke in early life. These findings support stronger recommendations to protect all infants from tobacco smoke exposure. TRIAL REGISTRY: Australian and New Zealand Clinical Trials Registry; No.: ACTRN12609000734268; URL: http://www.anzctr.org.au/. SN - 1931-3543 UR - https://www.unboundmedicine.com/medline/citation/30616740/Interaction_of_Glutathione_S_Transferase_M1_T1_and_P1_Genes_With_Early_Life_Tobacco_Smoke_Exposure_on_Lung_Function_in_Adolescents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(18)32441-3 DB - PRIME DP - Unbound Medicine ER -