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Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720.
Nat Prod Res. 2020 May; 34(9):1197-1205.NP

Abstract

Two new compounds, 5-[2-hydroxypropane-1-yl]-2,6-dimethlbenzene-1,3-diol (1) and coniochaetone L (2), together with 19 known compounds (3-21), were isolated from a deep-sea fungus, Penicillium sp. SCSIO 06720. Their structures and absolute configurations were elucidated by detailed NMR, MS spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism spectra. All the isolated compounds (1-21) were tested for their antibacterial and HIV latency-reversal activities. Among these compounds, compound 16 showed moderate antibacterial activities against Staphylococcus aureus ATCC 29213 and Methicillin-Resistant Staphylococcus Aureus-shh-1 with MIC values of 10.4 ± 3.7 μg/mL and 46.9 ± 29.7 μg/mL, respectively, which were comparable to that of the positive control ampicillin with MIC values of 0.5 ± 0.4 μg/mL and 2.7 ± 0.9 μg/mL, respectively.

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Authors+Show Affiliations

Guo C
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China. University of Chinese Academy of Sciences, Beijing, China.
Lin XP
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
Liao SR
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
Yang B
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
Zhou XF
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
Yang XW
State Key Laboratory Breeding Base of Marine Genetic Resources Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, China.
Tian XP
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
Wang JF
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China.
Liu YH
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou, China. University of Chinese Academy of Sciences, Beijing, China.

MeSH

Anti-Bacterial AgentsAnti-HIV AgentsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructurePenicilliumPolyketidesStaphylococcus aureus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30618287

Citation

Guo, Cui, et al. "Two New Aromatic Polyketides From a Deep-sea Fungus Penicillium Sp. SCSIO 06720." Natural Product Research, vol. 34, no. 9, 2020, pp. 1197-1205.
Guo C, Lin XP, Liao SR, et al. Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. Nat Prod Res. 2020;34(9):1197-1205.
Guo, C., Lin, X. P., Liao, S. R., Yang, B., Zhou, X. F., Yang, X. W., Tian, X. P., Wang, J. F., & Liu, Y. H. (2020). Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. Natural Product Research, 34(9), 1197-1205. https://doi.org/10.1080/14786419.2018.1553880
Guo C, et al. Two New Aromatic Polyketides From a Deep-sea Fungus Penicillium Sp. SCSIO 06720. Nat Prod Res. 2020;34(9):1197-1205. PubMed PMID: 30618287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. AU - Guo,Cui, AU - Lin,Xiu-Ping, AU - Liao,Sheng-Rong, AU - Yang,Bin, AU - Zhou,Xue-Feng, AU - Yang,Xian-Wen, AU - Tian,Xin-Peng, AU - Wang,Jun-Feng, AU - Liu,Yong-Hong, Y1 - 2019/01/08/ PY - 2019/1/9/pubmed PY - 2020/7/2/medline PY - 2019/1/9/entrez KW - Deep-sea fungus KW - Penicillium sp. KW - benzopyranone KW - phenyl derivative SP - 1197 EP - 1205 JF - Natural product research JO - Nat Prod Res VL - 34 IS - 9 N2 - Two new compounds, 5-[2-hydroxypropane-1-yl]-2,6-dimethlbenzene-1,3-diol (1) and coniochaetone L (2), together with 19 known compounds (3-21), were isolated from a deep-sea fungus, Penicillium sp. SCSIO 06720. Their structures and absolute configurations were elucidated by detailed NMR, MS spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism spectra. All the isolated compounds (1-21) were tested for their antibacterial and HIV latency-reversal activities. Among these compounds, compound 16 showed moderate antibacterial activities against Staphylococcus aureus ATCC 29213 and Methicillin-Resistant Staphylococcus Aureus-shh-1 with MIC values of 10.4 ± 3.7 μg/mL and 46.9 ± 29.7 μg/mL, respectively, which were comparable to that of the positive control ampicillin with MIC values of 0.5 ± 0.4 μg/mL and 2.7 ± 0.9 μg/mL, respectively. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/30618287/Two_new_aromatic_polyketides_from_a_deep_sea_fungus_Penicillium_sp__SCSIO_06720_ DB - PRIME DP - Unbound Medicine ER -