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Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder.
Front Behav Neurosci 2018; 12:319FB

Abstract

Background:

Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments.

Methods:

The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Resting-state scan was administrated and seed-based whole-brain FC analyses were performed with seeds located in classical DMN regions including bilateral medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC).

Results:

Both SCZ and OCD patients had poorer sustained attention than HCs. Sustained attention deficits in OCD was negatively correlated with their impaired FC of right mPFC-left superior frontal gyrus (SFG) within DMN, and that in SCZ was significantly correlated with their altered FC of left mPFC-bilateral anterior cingulate cortex (ACC) which indicated interaction between DMN and salience network. In addition, the FC between left mPFC and right parietal lobe indicating the interaction between DMN and frontal-parietal network was correlated with sustained attention in both SCZ and OCD.

Conclusion:

These findings suggest the importance of DMN-involved connectivity, both within and between networks in underlying sustained attention deficits in OCD and SCZ. Results further support the potential of resting-state FC in complementing information for cognitive deficits in psychiatric disorders.

Authors+Show Affiliations

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China. Medical Psychological Institute of Central South University, Changsha, China.Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China. Medical Psychological Institute of Central South University, Changsha, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30618669

Citation

Fan, Jie, et al. "Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder." Frontiers in Behavioral Neuroscience, vol. 12, 2018, p. 319.
Fan J, Gan J, Liu W, et al. Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder. Front Behav Neurosci. 2018;12:319.
Fan, J., Gan, J., Liu, W., Zhong, M., Liao, H., Zhang, H., ... Zhu, X. (2018). Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder. Frontiers in Behavioral Neuroscience, 12, p. 319. doi:10.3389/fnbeh.2018.00319.
Fan J, et al. Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder. Front Behav Neurosci. 2018;12:319. PubMed PMID: 30618669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder. AU - Fan,Jie, AU - Gan,Jun, AU - Liu,Wanting, AU - Zhong,Mingtian, AU - Liao,Haiyan, AU - Zhang,Hongchun, AU - Yi,Jinyao, AU - Chan,Raymond C K, AU - Tan,Changlian, AU - Zhu,Xiongzhao, Y1 - 2018/12/19/ PY - 2018/07/13/received PY - 2018/12/05/accepted PY - 2019/1/9/entrez PY - 2019/1/9/pubmed PY - 2019/1/9/medline KW - default mode network KW - frontal-parietal network KW - resting-state functional connectivity KW - salience network KW - sustained attention KW - sustained attention to response task SP - 319 EP - 319 JF - Frontiers in behavioral neuroscience JO - Front Behav Neurosci VL - 12 N2 - Background: Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments. Methods: The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Resting-state scan was administrated and seed-based whole-brain FC analyses were performed with seeds located in classical DMN regions including bilateral medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Results: Both SCZ and OCD patients had poorer sustained attention than HCs. Sustained attention deficits in OCD was negatively correlated with their impaired FC of right mPFC-left superior frontal gyrus (SFG) within DMN, and that in SCZ was significantly correlated with their altered FC of left mPFC-bilateral anterior cingulate cortex (ACC) which indicated interaction between DMN and salience network. In addition, the FC between left mPFC and right parietal lobe indicating the interaction between DMN and frontal-parietal network was correlated with sustained attention in both SCZ and OCD. Conclusion: These findings suggest the importance of DMN-involved connectivity, both within and between networks in underlying sustained attention deficits in OCD and SCZ. Results further support the potential of resting-state FC in complementing information for cognitive deficits in psychiatric disorders. SN - 1662-5153 UR - https://www.unboundmedicine.com/medline/citation/30618669/Resting_State_Default_Mode_Network_Related_Functional_Connectivity_Is_Associated_With_Sustained_Attention_Deficits_in_Schizophrenia_and_Obsessive_Compulsive_Disorder_ L2 - https://doi.org/10.3389/fnbeh.2018.00319 DB - PRIME DP - Unbound Medicine ER -