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The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study.
Front Physiol 2018; 9:1822FP

Abstract

Background:

Stimulation of the right and left anterior insular cortex, increases and decreases the cardiovascular response respectively, thus indicating the brain's lateralization of the neural control of circulation. Previous experiments have demonstrated that transcranial direct current stimulation (tDCS) modulates the autonomic cardiovascular control when applied over the temporal cortex. Given the importance of neural control for a normal hemodynamic response, and the potential for the use of tDCS in the treatment of cardiovascular diseases, this study investigated whether tDCS was capable of modulating autonomic regulation.

Methods:

Cardiovascular response was monitored during a post-exercise muscle ischemia (PEMI) test, which is well-documented to increase sympathetic drive. A group of 12 healthy participants performed a PEMI test in a control (Control), sham (Sham) and two different experimental sessions where the anodal electrode was applied over the left temporal cortex and right temporal cortex with the cathodal electrode placed over the contralateral supraorbital area. Stimulation lasted 20 min at 2 mA. The hemodynamic profile was measured during a PEMI test. The cardiovascular parameters were continuously measured with a transthoracic bio-impedance device both during the PEMI test and during tDCS.

Results:

None of the subjects presented any side effects during or after tDCS stimulation. A consistent cardiovascular response during PEMI test was observed in all conditions. Statistical analysis did not find any significant interaction and any significant main effect of condition on cardiovascular parameters (all ps > 0.316) after tDCS. No statistical differences regarding the hemodynamic responses were found between conditions and time during tDCS stimulation (p > 0.05). Discussion: This is the first study comparing the cardiovascular response after tDCS stimulation of left and right TC both during exercise and at rest. The results of the current study suggest that anodal tDCS of the left and right TC does not affect functional cardiovascular response during exercise PEMI test and during tDCS. In light of the present and previous findings, the effect of tDCS on the cardiovascular response remains inconclusive.

Authors+Show Affiliations

Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Kent, United Kingdom.Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Kent, United Kingdom.Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Kent, United Kingdom.Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Kent, United Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30618831

Citation

Angius, Luca, et al. "The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex On the Cardiovascular Response: a Comparative Study." Frontiers in Physiology, vol. 9, 2018, p. 1822.
Angius L, Marcora SM, Hopker JG, et al. The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study. Front Physiol. 2018;9:1822.
Angius, L., Marcora, S. M., Hopker, J. G., & Mauger, A. R. (2018). The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study. Frontiers in Physiology, 9, p. 1822. doi:10.3389/fphys.2018.01822.
Angius L, et al. The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex On the Cardiovascular Response: a Comparative Study. Front Physiol. 2018;9:1822. PubMed PMID: 30618831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study. AU - Angius,Luca, AU - Marcora,Samuele M, AU - Hopker,James G, AU - Mauger,Alexis R, Y1 - 2018/12/18/ PY - 2018/10/11/received PY - 2018/12/05/accepted PY - 2019/1/9/entrez PY - 2019/1/9/pubmed PY - 2019/1/9/medline KW - autonomic nervous system KW - cardiac output KW - cardiovascular KW - heart rate KW - metaboreflex KW - tDCS SP - 1822 EP - 1822 JF - Frontiers in physiology JO - Front Physiol VL - 9 N2 - Background: Stimulation of the right and left anterior insular cortex, increases and decreases the cardiovascular response respectively, thus indicating the brain's lateralization of the neural control of circulation. Previous experiments have demonstrated that transcranial direct current stimulation (tDCS) modulates the autonomic cardiovascular control when applied over the temporal cortex. Given the importance of neural control for a normal hemodynamic response, and the potential for the use of tDCS in the treatment of cardiovascular diseases, this study investigated whether tDCS was capable of modulating autonomic regulation. Methods: Cardiovascular response was monitored during a post-exercise muscle ischemia (PEMI) test, which is well-documented to increase sympathetic drive. A group of 12 healthy participants performed a PEMI test in a control (Control), sham (Sham) and two different experimental sessions where the anodal electrode was applied over the left temporal cortex and right temporal cortex with the cathodal electrode placed over the contralateral supraorbital area. Stimulation lasted 20 min at 2 mA. The hemodynamic profile was measured during a PEMI test. The cardiovascular parameters were continuously measured with a transthoracic bio-impedance device both during the PEMI test and during tDCS. Results: None of the subjects presented any side effects during or after tDCS stimulation. A consistent cardiovascular response during PEMI test was observed in all conditions. Statistical analysis did not find any significant interaction and any significant main effect of condition on cardiovascular parameters (all ps > 0.316) after tDCS. No statistical differences regarding the hemodynamic responses were found between conditions and time during tDCS stimulation (p > 0.05). Discussion: This is the first study comparing the cardiovascular response after tDCS stimulation of left and right TC both during exercise and at rest. The results of the current study suggest that anodal tDCS of the left and right TC does not affect functional cardiovascular response during exercise PEMI test and during tDCS. In light of the present and previous findings, the effect of tDCS on the cardiovascular response remains inconclusive. SN - 1664-042X UR - https://www.unboundmedicine.com/medline/citation/30618831/The_Effect_of_Anodal_Transcranial_Direct_Current_Stimulation_Over_Left_and_Right_Temporal_Cortex_on_the_Cardiovascular_Response:_A_Comparative_Study_ L2 - https://dx.doi.org/10.3389/fphys.2018.01822 DB - PRIME DP - Unbound Medicine ER -