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Therapeutic potential of polysaccharide extracted from fenugreek seeds against thiamethoxam-induced hepatotoxicity and genotoxicity in Wistar adult rats.
Toxicol Mech Methods. 2019 Jun; 29(5):355-367.TM

Abstract

This study aimed to evaluate the protective effect of a polysaccharide extracted from fenugreek seeds (Trigonella foenum-graecum) (FWEP) against insecticide-thiamethoxam (TMX)-induced hepatotoxicity. Obtained data exhibited potent antioxidant and antibacterial potentialities. On other trend, in vivo, adult female rats were divided into four groups: controls; TMX (100 mg/kg of body weight); TMX + FWEP at two graded doses, respectively (100 and 200 mg/kg of body weight) for 30 d. Up to TMX treatment, our data showed a significant increase in plasma markers of hepatotoxicity including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and in lactate dehydrogenase (LDH) activities, which is coordinated with decline in total protein and albumin levels. Remarkably, a clear sign of genotoxicity was delivered by total disruption in hematological parameters and micronucleus (MN) test shown by severe chromatin degradation. These data were also associated with oxidative stress set up, histological and DNA injuries. However, co-administration with FWEP succeeded significantly in a dose-dependent manner in reducing and healing liver's hematological and genotoxic induced by TMX injuries.

Authors+Show Affiliations

a Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax , University of Sfax , Sfax , Tunisia.a Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax , University of Sfax , Sfax , Tunisia.b Unit of Biotechnology and Pathology , Higher Institute of Biotechnology of Sfax , Sfax , Tunisia.a Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax , University of Sfax , Sfax , Tunisia.c Laboratory of Biochemistry , CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.c Laboratory of Biochemistry , CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.d Laboratory of Anatomopathology , CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.d Laboratory of Anatomopathology , CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.e Laboratory of Hematology , CHU Habib Bourguiba, University of Sfax , Sfax , Tunisia.a Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax , University of Sfax , Sfax , Tunisia.a Laboratory of Enzyme Engineering and Microbiology, National Engineering School of Sfax , University of Sfax , Sfax , Tunisia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30621503

Citation

Feki, Amal, et al. "Therapeutic Potential of Polysaccharide Extracted From Fenugreek Seeds Against Thiamethoxam-induced Hepatotoxicity and Genotoxicity in Wistar Adult Rats." Toxicology Mechanisms and Methods, vol. 29, no. 5, 2019, pp. 355-367.
Feki A, Jaballi I, Cherif B, et al. Therapeutic potential of polysaccharide extracted from fenugreek seeds against thiamethoxam-induced hepatotoxicity and genotoxicity in Wistar adult rats. Toxicol Mech Methods. 2019;29(5):355-367.
Feki, A., Jaballi, I., Cherif, B., Ktari, N., Naifar, M., Makni Ayadi, F., Kallel, R., Boudawara, O., Kallel, C., Nasri, M., & Ben Amara, I. (2019). Therapeutic potential of polysaccharide extracted from fenugreek seeds against thiamethoxam-induced hepatotoxicity and genotoxicity in Wistar adult rats. Toxicology Mechanisms and Methods, 29(5), 355-367. https://doi.org/10.1080/15376516.2018.1564949
Feki A, et al. Therapeutic Potential of Polysaccharide Extracted From Fenugreek Seeds Against Thiamethoxam-induced Hepatotoxicity and Genotoxicity in Wistar Adult Rats. Toxicol Mech Methods. 2019;29(5):355-367. PubMed PMID: 30621503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic potential of polysaccharide extracted from fenugreek seeds against thiamethoxam-induced hepatotoxicity and genotoxicity in Wistar adult rats. AU - Feki,Amal, AU - Jaballi,Imen, AU - Cherif,Boutheina, AU - Ktari,Naourez, AU - Naifar,Manel, AU - Makni Ayadi,Fatma, AU - Kallel,Rim, AU - Boudawara,Ons, AU - Kallel,Choumous, AU - Nasri,Moncef, AU - Ben Amara,Ibtissem, Y1 - 2019/02/22/ PY - 2019/1/10/pubmed PY - 2019/9/3/medline PY - 2019/1/10/entrez KW - Thiamethoxam KW - genotoxicity KW - oxidative stress KW - polysaccharide SP - 355 EP - 367 JF - Toxicology mechanisms and methods JO - Toxicol Mech Methods VL - 29 IS - 5 N2 - This study aimed to evaluate the protective effect of a polysaccharide extracted from fenugreek seeds (Trigonella foenum-graecum) (FWEP) against insecticide-thiamethoxam (TMX)-induced hepatotoxicity. Obtained data exhibited potent antioxidant and antibacterial potentialities. On other trend, in vivo, adult female rats were divided into four groups: controls; TMX (100 mg/kg of body weight); TMX + FWEP at two graded doses, respectively (100 and 200 mg/kg of body weight) for 30 d. Up to TMX treatment, our data showed a significant increase in plasma markers of hepatotoxicity including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and in lactate dehydrogenase (LDH) activities, which is coordinated with decline in total protein and albumin levels. Remarkably, a clear sign of genotoxicity was delivered by total disruption in hematological parameters and micronucleus (MN) test shown by severe chromatin degradation. These data were also associated with oxidative stress set up, histological and DNA injuries. However, co-administration with FWEP succeeded significantly in a dose-dependent manner in reducing and healing liver's hematological and genotoxic induced by TMX injuries. SN - 1537-6524 UR - https://www.unboundmedicine.com/medline/citation/30621503/Therapeutic_potential_of_polysaccharide_extracted_from_fenugreek_seeds_against_thiamethoxam_induced_hepatotoxicity_and_genotoxicity_in_Wistar_adult_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/15376516.2018.1564949 DB - PRIME DP - Unbound Medicine ER -