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Chlamydia trachomatis screening in urine among asymptomatic men attending an STI clinic in Paris: a cross-sectional study.
BMC Infect Dis. 2019 Jan 08; 19(1):31.BI

Abstract

BACKGROUND

The incidence of Chlamydia trachomatis (Ct) urethritis has been increasing for the past 10 years. There is little data regarding the screening of Ct infection in asymptomatic men in France, despite the national recommendation to screen at-risk asymptomatic men under 30 attending Sexually Transmitted Infections (STI) clinics. Recent data from the French surveillance network Rénachla show indeed that systematic screening is still focused on women. The objective of our study was to determine the prevalence and risk factors for Ct infection in asymptomatic men under 30 attending an STI clinic located in Paris, France.

METHODS

We performed a cross-sectional study between April 4, and December 31, 2016 in the database of the software DIAMM Client V8 used in our STI clinic. We extracted the demographic characteristics, sexual behavior and result of STI screening of all asymptomatic men who had consulted and given their consent for the use of their personal data. Those data were collected in usual care through a standardized questionnaire filled in during an appointment with a trained physician. STI screening was performed using PCR kit CT/NG Abbott Realtime® on first void urines. For MSM, a rectal swab was also collected. Risk factors for Ct infection were analyzed by univariate and multivariate modeling using STATA software 8.2.

RESULTS

Among 872 men who had attended the clinic, 647 were included and 37 (5.7, 95% CI 4.2 to 7.8) were positive for Ct in urine. In univariate analysis, men who had unprotected sex in the last 6 weeks (OR 2.40 (95%CI 1.16 to 4.94), p = 0.02), and those who had an infected partner (OR 7.6 (95%CI 3.03 to 20), p = 0.0001) were more likely to be infected. In the multivariate analysis having an infected partner was the only risk factor (OR 11.1(95% CI 3.7 to 33.3), p = 0.0001) that remained significant.

CONCLUSION

Prevalence of Ct infection is high among asymptomatic men of 30 years or less attending our urban STI clinic especially among those with an infected partner. The Ct screening among this population associated with partner notification, as recommended by the French national guidelines, should be more widely implemented.

Authors+Show Affiliations

Department of Infectious Diseases, University Hospital Saint-Antoine, APHP, 75012, Paris, France. Paulprondeau@gmail.com.Department of Infectious Diseases, University Hospital Saint-Antoine, APHP, 75012, Paris, France.Department of Bacteriology, University Hospital Saint-Antoine, APHP, 75012, Paris, France. Sorbonne University, UPMC Univ Paris 06 CR7, Paris, France; INSERM U1135, CIMI, Team E13, 75012, Paris, France.Department of Infectious Diseases, University Hospital Saint-Antoine, APHP, 75012, Paris, France. Sorbonne University, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France.Department of Infectious Diseases, University Hospital Saint-Antoine, APHP, 75012, Paris, France. Sorbonne University, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France.Department of Infectious Diseases, University Hospital Saint-Antoine, APHP, 75012, Paris, France. Sorbonne University, UPMC Univ Paris 06 CR7, Paris, France; INSERM U1135, CIMI, Team E13, 75012, Paris, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30621621

Citation

Rondeau, Paul, et al. "Chlamydia Trachomatis Screening in Urine Among Asymptomatic Men Attending an STI Clinic in Paris: a Cross-sectional Study." BMC Infectious Diseases, vol. 19, no. 1, 2019, p. 31.
Rondeau P, Valin N, Decré D, et al. Chlamydia trachomatis screening in urine among asymptomatic men attending an STI clinic in Paris: a cross-sectional study. BMC Infect Dis. 2019;19(1):31.
Rondeau, P., Valin, N., Decré, D., Girard, P. M., Lacombe, K., & Surgers, L. (2019). Chlamydia trachomatis screening in urine among asymptomatic men attending an STI clinic in Paris: a cross-sectional study. BMC Infectious Diseases, 19(1), 31. https://doi.org/10.1186/s12879-018-3595-6
Rondeau P, et al. Chlamydia Trachomatis Screening in Urine Among Asymptomatic Men Attending an STI Clinic in Paris: a Cross-sectional Study. BMC Infect Dis. 2019 Jan 8;19(1):31. PubMed PMID: 30621621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlamydia trachomatis screening in urine among asymptomatic men attending an STI clinic in Paris: a cross-sectional study. AU - Rondeau,Paul, AU - Valin,Nadia, AU - Decré,Dominique, AU - Girard,Pierre-Marie, AU - Lacombe,Karine, AU - Surgers,Laure, Y1 - 2019/01/08/ PY - 2018/04/16/received PY - 2018/12/07/accepted PY - 2019/1/10/entrez PY - 2019/1/10/pubmed PY - 2019/2/16/medline KW - Chlamydia trachomatis KW - Screening men urine SP - 31 EP - 31 JF - BMC infectious diseases JO - BMC Infect Dis VL - 19 IS - 1 N2 - BACKGROUND: The incidence of Chlamydia trachomatis (Ct) urethritis has been increasing for the past 10 years. There is little data regarding the screening of Ct infection in asymptomatic men in France, despite the national recommendation to screen at-risk asymptomatic men under 30 attending Sexually Transmitted Infections (STI) clinics. Recent data from the French surveillance network Rénachla show indeed that systematic screening is still focused on women. The objective of our study was to determine the prevalence and risk factors for Ct infection in asymptomatic men under 30 attending an STI clinic located in Paris, France. METHODS: We performed a cross-sectional study between April 4, and December 31, 2016 in the database of the software DIAMM Client V8 used in our STI clinic. We extracted the demographic characteristics, sexual behavior and result of STI screening of all asymptomatic men who had consulted and given their consent for the use of their personal data. Those data were collected in usual care through a standardized questionnaire filled in during an appointment with a trained physician. STI screening was performed using PCR kit CT/NG Abbott Realtime® on first void urines. For MSM, a rectal swab was also collected. Risk factors for Ct infection were analyzed by univariate and multivariate modeling using STATA software 8.2. RESULTS: Among 872 men who had attended the clinic, 647 were included and 37 (5.7, 95% CI 4.2 to 7.8) were positive for Ct in urine. In univariate analysis, men who had unprotected sex in the last 6 weeks (OR 2.40 (95%CI 1.16 to 4.94), p = 0.02), and those who had an infected partner (OR 7.6 (95%CI 3.03 to 20), p = 0.0001) were more likely to be infected. In the multivariate analysis having an infected partner was the only risk factor (OR 11.1(95% CI 3.7 to 33.3), p = 0.0001) that remained significant. CONCLUSION: Prevalence of Ct infection is high among asymptomatic men of 30 years or less attending our urban STI clinic especially among those with an infected partner. The Ct screening among this population associated with partner notification, as recommended by the French national guidelines, should be more widely implemented. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/30621621/Chlamydia_trachomatis_screening_in_urine_among_asymptomatic_men_attending_an_STI_clinic_in_Paris:_a_cross_sectional_study_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-018-3595-6 DB - PRIME DP - Unbound Medicine ER -