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Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort.
Environ Res. 2019 03; 170:398-405.ER

Abstract

Bisphenol A (BPA) is a non-persistent chemical with endocrine disrupting abilities widely used in a variety of consumer products. The fetal brain is particularly sensitive to chemical exposures due to its rapid growth and complexity. Some studies have reported associationbetween maternal BPA exposure and behavior but few have assessed impact on cognitive development, and to our knowledge no studies have specifically assessed the impact on language development. We therefore assessed whether maternal urinary BPA concentration during pregnancy was associated with language development and attention-deficit and hyperactivity disorder (ADHD) symptoms in offspring aged 18-36 months in the prospective Odense Child Cohort. BPA was analyzed in 3rd trimester maternal fasting urine spot samples. Language development was addressed among 535 children using the Danish adaptation of the MacArthur-Bates Communicative Development Inventories at median age 21 months; ADHD traits were assessed by parents of 658 children using the Child Behavior Checklist for ages 1½-5 years at mean age 2.7 years. Associations were assessed using logistic regression models comparing children below the 15th percentile score for language and above the 85 percentiles score for ADHD with the other children while stratifying by sex and adjusting for maternal education, duration of breastfeeding and maternal urine phthalates. BPA was detected in 85.3% of the urine samples (median 1.2 ng/ml). Boys of mothers with BPA exposure in the highest tertile had an odds ratio of 3.70 (95% CI 1.34-10.21) of being in the lowest 15th percentile of vocabulary score compared to boys of mothers within the lowest tertile of BPA exposure after adjustment, whereas no association was found in girls. No clear dose-response relationship between maternal BPA and ADHD scores above the 85th percentile was found for either sex. Since early language development is a predictor of future reading skills and educational success, more epidemiological studies assessing BPA exposure and language skills are needed to confirm our findings.

Authors+Show Affiliations

Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Hans Christian Andersen Children's Hospital, Odense University Hospital, Denmark; Odense Patient data Explorative Network (OPEN), Odense, Denmark. Electronic address: kjensen@health.sdu.dk.Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada, Spain; Center for Biomedical Research (CIBM), University of Granada, Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain.TrygFonden's Centre for Child Research and School of Communication and Culture, Aarhus, Denmark.Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.School of Communication and Culture, Aarhus University, Aarhus, Denmark.Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Unit Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Mol, Belgium.Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.Hans Christian Andersen Children's Hospital, Odense University Hospital, Denmark; Odense Patient data Explorative Network (OPEN), Odense, Denmark.Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.Department of Child and Adolescent Mental Health Odense, Mental Health Services in the Region of Southern Denmark, University of Southern Denmark, Odense, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30623887

Citation

Jensen, Tina Kold, et al. "Prenatal Bisphenol a Exposure Is Associated With Language Development but Not With ADHD-related Behavior in Toddlers From the Odense Child Cohort." Environmental Research, vol. 170, 2019, pp. 398-405.
Jensen TK, Mustieles V, Bleses D, et al. Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort. Environ Res. 2019;170:398-405.
Jensen, T. K., Mustieles, V., Bleses, D., Frederiksen, H., Trecca, F., Schoeters, G., Andersen, H. R., Grandjean, P., Kyhl, H. B., Juul, A., Bilenberg, N., & Andersson, A. M. (2019). Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort. Environmental Research, 170, 398-405. https://doi.org/10.1016/j.envres.2018.12.055
Jensen TK, et al. Prenatal Bisphenol a Exposure Is Associated With Language Development but Not With ADHD-related Behavior in Toddlers From the Odense Child Cohort. Environ Res. 2019;170:398-405. PubMed PMID: 30623887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal bisphenol A exposure is associated with language development but not with ADHD-related behavior in toddlers from the Odense Child Cohort. AU - Jensen,Tina Kold, AU - Mustieles,Vicente, AU - Bleses,Dorthe, AU - Frederiksen,Hanne, AU - Trecca,Fabio, AU - Schoeters,Greet, AU - Andersen,Helle Raun, AU - Grandjean,Philippe, AU - Kyhl,Henriette Boye, AU - Juul,Anders, AU - Bilenberg,Niels, AU - Andersson,Anna-Maria, Y1 - 2018/12/24/ PY - 2018/10/16/received PY - 2018/12/11/revised PY - 2018/12/21/accepted PY - 2019/1/10/pubmed PY - 2019/12/19/medline PY - 2019/1/10/entrez KW - ADHD KW - Bisphenol A KW - Endocrine disruptors KW - Language KW - Neurodevelopment SP - 398 EP - 405 JF - Environmental research JO - Environ. Res. VL - 170 N2 - Bisphenol A (BPA) is a non-persistent chemical with endocrine disrupting abilities widely used in a variety of consumer products. The fetal brain is particularly sensitive to chemical exposures due to its rapid growth and complexity. Some studies have reported associationbetween maternal BPA exposure and behavior but few have assessed impact on cognitive development, and to our knowledge no studies have specifically assessed the impact on language development. We therefore assessed whether maternal urinary BPA concentration during pregnancy was associated with language development and attention-deficit and hyperactivity disorder (ADHD) symptoms in offspring aged 18-36 months in the prospective Odense Child Cohort. BPA was analyzed in 3rd trimester maternal fasting urine spot samples. Language development was addressed among 535 children using the Danish adaptation of the MacArthur-Bates Communicative Development Inventories at median age 21 months; ADHD traits were assessed by parents of 658 children using the Child Behavior Checklist for ages 1½-5 years at mean age 2.7 years. Associations were assessed using logistic regression models comparing children below the 15th percentile score for language and above the 85 percentiles score for ADHD with the other children while stratifying by sex and adjusting for maternal education, duration of breastfeeding and maternal urine phthalates. BPA was detected in 85.3% of the urine samples (median 1.2 ng/ml). Boys of mothers with BPA exposure in the highest tertile had an odds ratio of 3.70 (95% CI 1.34-10.21) of being in the lowest 15th percentile of vocabulary score compared to boys of mothers within the lowest tertile of BPA exposure after adjustment, whereas no association was found in girls. No clear dose-response relationship between maternal BPA and ADHD scores above the 85th percentile was found for either sex. Since early language development is a predictor of future reading skills and educational success, more epidemiological studies assessing BPA exposure and language skills are needed to confirm our findings. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/30623887/Prenatal_bisphenol_A_exposure_is_associated_with_language_development_but_not_with_ADHD_related_behavior_in_toddlers_from_the_Odense_Child_Cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(18)30690-X DB - PRIME DP - Unbound Medicine ER -