Tags

Type your tag names separated by a space and hit enter

Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France).
Environ Health Perspect. 2019 01; 127(1):17002.EH

Abstract

BACKGROUND

The placenta performs crucial physiological functions to ensure normal fetal development. Few epidemiological studies investigated placental weight sensitivity to phthalates and phenols.

OBJECTIVE

Our goal was to explore whether maternal exposure to select phthalates and phenols is associated with changes in placental weight at birth and in placental–to–birth weight ratio (PFR).

METHODS

Placental weight and birth weight were available for 473 mother–son pairs in the EDEN (Etude des Déterminants pré et postnatals du développement et de la santé de l'Enfant) cohort for whom 9 phenols (4 parabens, 2 dichlorophenols, triclosan, benzophenone-3, bisphenol A) and 11 phthalate metabolites were measured in spot urine samples collected between weeks 23 and 29 of gestation. We used adjusted Elastic Net penalized regression models (ENET) to select biomarkers associated with placental weight, birth weight and PFR. Unpenalized effect estimates were then obtained by fitting linear regression models simultaneously adjusted for the ENET-selected biomarkers and a priori chosen confounders.

RESULTS

The multipollutant ENET model for placental weight retained four biomarkers: triclosan and monocarboxy-isononyl phthalate (MCNP), which were negatively associated with placental weight, and benzophenone-3 and the sum of parabens, which were positively associated with this outcome. The ENET model for PFR retained two phthalate metabolites [MCNP and monocarboxy-isooctyl phthalate (MCOP)], which were negatively associated with this outcome.

DISCUSSION

The positive association between the sum of parabens and placental weight was consistent with results of a previous study among 49 male births. Our results provide preliminary evidence of possible associations between other compounds such as triclosan, benzophenone-3, MCNP, and MCOP and both placental weight and PFR. These associations were not reported in previous studies and should be seen as hypothesis generating. Studies relying on repeated assessments of exposure in prospective mother–child cohorts are needed to substantiate the plausibility of the hypotheses generated by our results. https://doi.org/10.1289/EHP3523.

Authors+Show Affiliations

Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Centre national de la recherche scientifique (CNRS) Unité de recherche (UMR) 5309, Université Grenoble Alpes, Grenoble, France.Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm 1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Centre (CRESS), Villejuif, France. Université Paris Descartes, Villejuif, France.Faculty of Pharmacy, Université Paris-Sud/Université Paris-Saclay, Châtenay-Malabry, France.Commissariat à l'Energie Atomique et aux Energies Alternatives, CNRS, Inserm U1036, Biosciences and Biotechnology Institute of Grenoble, Université Grenoble Alpes, Grenoble, France.Centers for Disease Control and Prevention, Atlanta, Georgia, USA.Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Centre national de la recherche scientifique (CNRS) Unité de recherche (UMR) 5309, Université Grenoble Alpes, Grenoble, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30624098

Citation

Philippat, Claire, et al. "Prenatal Exposure to Select Phthalates and Phenols and Associations With Fetal and Placental Weight Among Male Births in the EDEN Cohort (France)." Environmental Health Perspectives, vol. 127, no. 1, 2019, p. 17002.
Philippat C, Heude B, Botton J, et al. Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France). Environ Health Perspect. 2019;127(1):17002.
Philippat, C., Heude, B., Botton, J., Alfaidy, N., Calafat, A. M., & Slama, R. (2019). Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France). Environmental Health Perspectives, 127(1), 17002. https://doi.org/10.1289/EHP3523
Philippat C, et al. Prenatal Exposure to Select Phthalates and Phenols and Associations With Fetal and Placental Weight Among Male Births in the EDEN Cohort (France). Environ Health Perspect. 2019;127(1):17002. PubMed PMID: 30624098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France). AU - Philippat,Claire, AU - Heude,Barbara, AU - Botton,Jérémie, AU - Alfaidy,Nadia, AU - Calafat,Antonia M, AU - Slama,Rémy, AU - ,, PY - 2019/1/10/entrez PY - 2019/1/10/pubmed PY - 2019/4/11/medline SP - 17002 EP - 17002 JF - Environmental health perspectives JO - Environ Health Perspect VL - 127 IS - 1 N2 - BACKGROUND: The placenta performs crucial physiological functions to ensure normal fetal development. Few epidemiological studies investigated placental weight sensitivity to phthalates and phenols. OBJECTIVE: Our goal was to explore whether maternal exposure to select phthalates and phenols is associated with changes in placental weight at birth and in placental–to–birth weight ratio (PFR). METHODS: Placental weight and birth weight were available for 473 mother–son pairs in the EDEN (Etude des Déterminants pré et postnatals du développement et de la santé de l'Enfant) cohort for whom 9 phenols (4 parabens, 2 dichlorophenols, triclosan, benzophenone-3, bisphenol A) and 11 phthalate metabolites were measured in spot urine samples collected between weeks 23 and 29 of gestation. We used adjusted Elastic Net penalized regression models (ENET) to select biomarkers associated with placental weight, birth weight and PFR. Unpenalized effect estimates were then obtained by fitting linear regression models simultaneously adjusted for the ENET-selected biomarkers and a priori chosen confounders. RESULTS: The multipollutant ENET model for placental weight retained four biomarkers: triclosan and monocarboxy-isononyl phthalate (MCNP), which were negatively associated with placental weight, and benzophenone-3 and the sum of parabens, which were positively associated with this outcome. The ENET model for PFR retained two phthalate metabolites [MCNP and monocarboxy-isooctyl phthalate (MCOP)], which were negatively associated with this outcome. DISCUSSION: The positive association between the sum of parabens and placental weight was consistent with results of a previous study among 49 male births. Our results provide preliminary evidence of possible associations between other compounds such as triclosan, benzophenone-3, MCNP, and MCOP and both placental weight and PFR. These associations were not reported in previous studies and should be seen as hypothesis generating. Studies relying on repeated assessments of exposure in prospective mother–child cohorts are needed to substantiate the plausibility of the hypotheses generated by our results. https://doi.org/10.1289/EHP3523. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/30624098/Prenatal_Exposure_to_Select_Phthalates_and_Phenols_and_Associations_with_Fetal_and_Placental_Weight_among_Male_Births_in_the_EDEN_Cohort__France__ L2 - https://ehp.niehs.nih.gov/doi/10.1289/EHP3523?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -