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Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health.
Expert Rev Anti Infect Ther. 2019 02; 17(2):129-139.ER

Abstract

INTRODUCTION

Monkeypox is a re-emerging viral zoonosis that occurs naturally in heavily forested regions of West and Central Africa. Inter-human transmission of monkeypox virus, although limited, drives outbreaks, particularly in household and health-care settings. But the available evidence suggests that without repeated zoonotic introductions, human infections would eventually cease to occur. Therefore, interrupting virus transmission from animals to humans is key to combating this disease. Areas covered: Herein we review laboratory and field studies examining the susceptibility of various animal taxa to monkeypox virus infection, and note the competence of various species to serve as reservoirs or transmission hosts. In addition, we discuss early socio-ecologic theories of monkeypox virus transmission in rural settings and review current modes of ecologic investigation - including ecologic niche modeling, and ecologic sampling - in light of their potential to identify specific animal species and features of the environment that are associated with heightened risk for human disease. Expert opinion: The role of disease ecology and scientific research in ongoing disease prevention efforts should be reinforced, particularly for wildlife-associated zoonoses such as monkeypox. Such efforts alongside those aimed at nurturing 'One Health' collaborations may ultimately hold the greatest promise for reducing human infections with this pathogen.

Links

Authors+Show Affiliations

a US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch , Atlanta , GA , USA.

a US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch , Atlanta , GA , USA.

a US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch , Atlanta , GA , USA.

a US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch , Atlanta , GA , USA.

a US Centers for Disease Control and Prevention, Poxvirus and Rabies Branch , Atlanta , GA , USA.

MeSH

Africa, CentralAfrica, WesternAnimalsAnimals, WildDisease OutbreaksHumansMonkeypoxMonkeypox virusOne HealthZoonoses

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

30625020

Citation

Reynolds, Mary G., et al. "Monkeypox Re-emergence in Africa: a Call to Expand the Concept and Practice of One Health." Expert Review of Anti-infective Therapy, vol. 17, no. 2, 2019, pp. 129-139.

Reynolds MG, Doty JB, McCollum AM, et al. Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health. Expert Rev Anti Infect Ther. 2019;17(2):129-139.

Reynolds, M. G., Doty, J. B., McCollum, A. M., Olson, V. A., & Nakazawa, Y. (2019). Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health. Expert Review of Anti-infective Therapy, 17(2), 129-139. https://doi.org/10.1080/14787210.2019.1567330

Reynolds MG, et al. Monkeypox Re-emergence in Africa: a Call to Expand the Concept and Practice of One Health. Expert Rev Anti Infect Ther. 2019;17(2):129-139. PubMed PMID: 30625020.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health. AU - Reynolds,Mary G, AU - Doty,Jeffry B, AU - McCollum,Andrea M, AU - Olson,Victoria A, AU - Nakazawa,Yoshinori, Y1 - 2019/01/21/ PY - 2019/1/10/pubmed PY - 2019/5/3/medline PY - 2019/1/10/entrez KW - Monkeypox KW - One Health KW - orthopoxvirus KW - zoonosis KW - SP - 129 EP - 139 JF - Expert review of anti-infective therapy JO - Expert Rev Anti Infect Ther VL - 17 IS - 2 N2 - INTRODUCTION: Monkeypox is a re-emerging viral zoonosis that occurs naturally in heavily forested regions of West and Central Africa. Inter-human transmission of monkeypox virus, although limited, drives outbreaks, particularly in household and health-care settings. But the available evidence suggests that without repeated zoonotic introductions, human infections would eventually cease to occur. Therefore, interrupting virus transmission from animals to humans is key to combating this disease. Areas covered: Herein we review laboratory and field studies examining the susceptibility of various animal taxa to monkeypox virus infection, and note the competence of various species to serve as reservoirs or transmission hosts. In addition, we discuss early socio-ecologic theories of monkeypox virus transmission in rural settings and review current modes of ecologic investigation - including ecologic niche modeling, and ecologic sampling - in light of their potential to identify specific animal species and features of the environment that are associated with heightened risk for human disease. Expert opinion: The role of disease ecology and scientific research in ongoing disease prevention efforts should be reinforced, particularly for wildlife-associated zoonoses such as monkeypox. Such efforts alongside those aimed at nurturing 'One Health' collaborations may ultimately hold the greatest promise for reducing human infections with this pathogen. SN - 1744-8336 UR - https://www.unboundmedicine.com/medline/citation/30625020/Monkeypox_re_emergence_in_Africa:_a_call_to_expand_the_concept_and_practice_of_One_Health_ DB - PRIME DP - Unbound Medicine ER -