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Benzodiazepines in Pregnancy.
Clin Obstet Gynecol 2019; 62(1):156-167CO

Abstract

Benzodiazepine use and dependence are on the rise as well as the number of deaths attributable to the combination of opioids and benzodiazepines. Anxiety, the most frequent condition for which benzodiazepines are prescribed, occurs commonly, and is increasingly noted to coincide with pregnancy. Use of both benzodiazepine anxiolytics and anxiety in pregnancy is associated with preterm delivery and low birth weight. Short-term neonatal effects of hypotonia, depression, and withdrawal are described but long-term sequelae, if any, are poorly understood. Benzodiazepines are associated with physical dependence and withdrawal symptoms which can be serious. To avoid withdrawal, tapering off these medications is recommended. What is known about the pharmacology and pharmacokinetics, pregnancy implications, tapering schedules, and alternative strategies for anxiety are discussed.

Authors+Show Affiliations

St. Louis University School of Medicine, St. Louis, Missouri.St. Louis University School of Medicine, St. Louis, Missouri.Kaiser Permanente, Denver, Colorado.St. Louis College of Pharmacy, St. Louis, Missouri.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30628916

Citation

Shyken, Jaye M., et al. "Benzodiazepines in Pregnancy." Clinical Obstetrics and Gynecology, vol. 62, no. 1, 2019, pp. 156-167.
Shyken JM, Babbar S, Babbar S, et al. Benzodiazepines in Pregnancy. Clin Obstet Gynecol. 2019;62(1):156-167.
Shyken, J. M., Babbar, S., Babbar, S., & Forinash, A. (2019). Benzodiazepines in Pregnancy. Clinical Obstetrics and Gynecology, 62(1), pp. 156-167. doi:10.1097/GRF.0000000000000417.
Shyken JM, et al. Benzodiazepines in Pregnancy. Clin Obstet Gynecol. 2019;62(1):156-167. PubMed PMID: 30628916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benzodiazepines in Pregnancy. AU - Shyken,Jaye M, AU - Babbar,Shilpa, AU - Babbar,Shaweta, AU - Forinash,Alicia, PY - 2019/1/11/pubmed PY - 2019/1/11/medline PY - 2019/1/11/entrez SP - 156 EP - 167 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 62 IS - 1 N2 - Benzodiazepine use and dependence are on the rise as well as the number of deaths attributable to the combination of opioids and benzodiazepines. Anxiety, the most frequent condition for which benzodiazepines are prescribed, occurs commonly, and is increasingly noted to coincide with pregnancy. Use of both benzodiazepine anxiolytics and anxiety in pregnancy is associated with preterm delivery and low birth weight. Short-term neonatal effects of hypotonia, depression, and withdrawal are described but long-term sequelae, if any, are poorly understood. Benzodiazepines are associated with physical dependence and withdrawal symptoms which can be serious. To avoid withdrawal, tapering off these medications is recommended. What is known about the pharmacology and pharmacokinetics, pregnancy implications, tapering schedules, and alternative strategies for anxiety are discussed. SN - 1532-5520 UR - https://www.unboundmedicine.com/medline/citation/30628916/Benzodiazepines_in_Pregnancy L2 - http://Insights.ovid.com/pubmed?pmid=30628916 DB - PRIME DP - Unbound Medicine ER -