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[Do kinins have significance for the antihypertensive effect of angiotensin-converting enzyme inhibitors?].
Z Kardiol. 1988; 77 Suppl 3:23-7.ZK

Abstract

Inhibition of angiotensin I converting enzyme (ACE, kininase II) results in a reduced release of angiotensin II and in an accumulation of kinins. By pretreatment with inhibitors of the kallikrein-kinin systems, the blood pressure lowering effect of the ACE-inhibitors will be diminished. These results suggest that potentiation of kinins will participate in the blood pressure reduction by ACE-inhibitors. However, other studies contradict this hypothesis, showing that the inhibition of kallikrein-kinin systems per se will often result in a reduction of stimulated renin activity. Even the measurement of kinins in the blood cannot clarify the role of kinins in ACE-inhibition. Some new investigations discuss only a local and tissue-specific enhancement of kinins after ACE-inhibition, but up to now strong evidence for participation of kinins by local mechanisms in the action of ACE-inhibitors is still missing.

Authors+Show Affiliations

Medizinische Universitätsklinik II, Krankenhaus Merheim, Köln.

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

3062958

Citation

Bönner, G. "[Do Kinins Have Significance for the Antihypertensive Effect of Angiotensin-converting Enzyme Inhibitors?]." Zeitschrift Fur Kardiologie, vol. 77 Suppl 3, 1988, pp. 23-7.
Bönner G. [Do kinins have significance for the antihypertensive effect of angiotensin-converting enzyme inhibitors?]. Z Kardiol. 1988;77 Suppl 3:23-7.
Bönner, G. (1988). [Do kinins have significance for the antihypertensive effect of angiotensin-converting enzyme inhibitors?]. Zeitschrift Fur Kardiologie, 77 Suppl 3, 23-7.
Bönner G. [Do Kinins Have Significance for the Antihypertensive Effect of Angiotensin-converting Enzyme Inhibitors?]. Z Kardiol. 1988;77 Suppl 3:23-7. PubMed PMID: 3062958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Do kinins have significance for the antihypertensive effect of angiotensin-converting enzyme inhibitors?]. A1 - Bönner,G, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 23 EP - 7 JF - Zeitschrift fur Kardiologie JO - Z Kardiol VL - 77 Suppl 3 N2 - Inhibition of angiotensin I converting enzyme (ACE, kininase II) results in a reduced release of angiotensin II and in an accumulation of kinins. By pretreatment with inhibitors of the kallikrein-kinin systems, the blood pressure lowering effect of the ACE-inhibitors will be diminished. These results suggest that potentiation of kinins will participate in the blood pressure reduction by ACE-inhibitors. However, other studies contradict this hypothesis, showing that the inhibition of kallikrein-kinin systems per se will often result in a reduction of stimulated renin activity. Even the measurement of kinins in the blood cannot clarify the role of kinins in ACE-inhibition. Some new investigations discuss only a local and tissue-specific enhancement of kinins after ACE-inhibition, but up to now strong evidence for participation of kinins by local mechanisms in the action of ACE-inhibitors is still missing. SN - 0300-5860 UR - https://www.unboundmedicine.com/medline/citation/3062958/[Do_kinins_have_significance_for_the_antihypertensive_effect_of_angiotensin_converting_enzyme_inhibitors]_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -