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Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity in healthy men with normal BMI compared to peanut oil.
Clin Nutr. 2019 12; 38(6):2889-2899.CN

Abstract

BACKGROUND & AIMS

The existing scientific evidence on coconut oil consumption and its health effects remains inconclusive due to varied reasons. In this context, we conducted a well-controlled metabolic study, eliminating some of the confounding factors and assessed the effects of the consumption of coconut oil-based diet on various anthropometric, biochemical and inflammatory markers and compared with peanut oil-diet.

METHODS

Nine healthy male volunteers with BMI ≤25 kg/m2 were enrolled for this study and given balanced diets prepared with coconut oil (CO; ~35 g) for a period of eight weeks. After a wash-out period of six weeks, the same subjects were provided with diets prepared with peanut oil (~35 g) for eight weeks. Except fat source, the composition of the diets was identical in all aspects.

RESULTS

Compared to basal values, there were significant increases in fat-free mass (p ≤ 0.022), plasma HDL-cholesterol (HDL-C) (p ≤ 0.047) and insulin sensitivity of the subjects at the end of CO-consumption. Further, compared to peanut oil, increase in plasma HDL-C was significant (p = 0.004) in CO treatment. On the other hand, plasma inflammatory markers-associated with cardiovascular diseases (CVD), namely soluble vascular cell adhesion molecule 1 (sVCAM1) and matrix metalloproteinase levels were reduced significantly by CO-intake. Further, these subjects displayed elevated levels of myristic acid (14:0) in plasma phospholipids at the end of CO-consumption, which correlated positively with HDL-C and negatively with sVCAM1. However, no such changes were observed after peanut oil diet consumption.

CONCLUSIONS

In conclusion, compared to peanut oil, the consumption of coconut oil in a balanced diet resulted in increased fat-free mass, plasma HDL-C, elicited favourable changes on insulin sensitivity and CVD risk-associated parameters in healthy men with normal BMI.

Authors+Show Affiliations

Division of Publication, Extension and Training, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.Division of Pathology, National Institute of Nutrition, Jamai-Osmania P.O., Hyderabad, 500007, India.Division of Statistics, National Institute of Nutrition, Jamai-Osmania P.O., Hyderabad, 500007, India.Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India.Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500 007, Telangana, India. Electronic address: vaj_lipidresearch@yahoo.com.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30630708

Citation

Korrapati, Damayanti, et al. "Coconut Oil Consumption Improves Fat-free Mass, Plasma HDL-cholesterol and Insulin Sensitivity in Healthy Men With Normal BMI Compared to Peanut Oil." Clinical Nutrition (Edinburgh, Scotland), vol. 38, no. 6, 2019, pp. 2889-2899.
Korrapati D, Jeyakumar SM, Putcha UK, et al. Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity in healthy men with normal BMI compared to peanut oil. Clin Nutr. 2019;38(6):2889-2899.
Korrapati, D., Jeyakumar, S. M., Putcha, U. K., Mendu, V. R., Ponday, L. R., Acharya, V., Koppala, S. R., & Vajreswari, A. (2019). Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity in healthy men with normal BMI compared to peanut oil. Clinical Nutrition (Edinburgh, Scotland), 38(6), 2889-2899. https://doi.org/10.1016/j.clnu.2018.12.026
Korrapati D, et al. Coconut Oil Consumption Improves Fat-free Mass, Plasma HDL-cholesterol and Insulin Sensitivity in Healthy Men With Normal BMI Compared to Peanut Oil. Clin Nutr. 2019;38(6):2889-2899. PubMed PMID: 30630708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity in healthy men with normal BMI compared to peanut oil. AU - Korrapati,Damayanti, AU - Jeyakumar,Shanmugam Murugaiha, AU - Putcha,Uday Kumar, AU - Mendu,Vishnuvardhana Rao, AU - Ponday,Laxmi Rajkumar, AU - Acharya,Vani, AU - Koppala,Swarupa Rani, AU - Vajreswari,Ayylasomayajula, Y1 - 2018/12/29/ PY - 2018/07/23/received PY - 2018/12/05/revised PY - 2018/12/21/accepted PY - 2019/1/12/pubmed PY - 2020/10/6/medline PY - 2019/1/12/entrez KW - Atherosclerosis KW - Dyslipidemia KW - Inflammation KW - Medium chain triglycerides KW - Obesity KW - Saturated fatty acids SP - 2889 EP - 2899 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 38 IS - 6 N2 - BACKGROUND & AIMS: The existing scientific evidence on coconut oil consumption and its health effects remains inconclusive due to varied reasons. In this context, we conducted a well-controlled metabolic study, eliminating some of the confounding factors and assessed the effects of the consumption of coconut oil-based diet on various anthropometric, biochemical and inflammatory markers and compared with peanut oil-diet. METHODS: Nine healthy male volunteers with BMI ≤25 kg/m2 were enrolled for this study and given balanced diets prepared with coconut oil (CO; ~35 g) for a period of eight weeks. After a wash-out period of six weeks, the same subjects were provided with diets prepared with peanut oil (~35 g) for eight weeks. Except fat source, the composition of the diets was identical in all aspects. RESULTS: Compared to basal values, there were significant increases in fat-free mass (p ≤ 0.022), plasma HDL-cholesterol (HDL-C) (p ≤ 0.047) and insulin sensitivity of the subjects at the end of CO-consumption. Further, compared to peanut oil, increase in plasma HDL-C was significant (p = 0.004) in CO treatment. On the other hand, plasma inflammatory markers-associated with cardiovascular diseases (CVD), namely soluble vascular cell adhesion molecule 1 (sVCAM1) and matrix metalloproteinase levels were reduced significantly by CO-intake. Further, these subjects displayed elevated levels of myristic acid (14:0) in plasma phospholipids at the end of CO-consumption, which correlated positively with HDL-C and negatively with sVCAM1. However, no such changes were observed after peanut oil diet consumption. CONCLUSIONS: In conclusion, compared to peanut oil, the consumption of coconut oil in a balanced diet resulted in increased fat-free mass, plasma HDL-C, elicited favourable changes on insulin sensitivity and CVD risk-associated parameters in healthy men with normal BMI. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/30630708/Coconut_oil_consumption_improves_fat_free_mass_plasma_HDL_cholesterol_and_insulin_sensitivity_in_healthy_men_with_normal_BMI_compared_to_peanut_oil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(18)32594-9 DB - PRIME DP - Unbound Medicine ER -