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Acne, the Skin Microbiome, and Antibiotic Treatment.
Am J Clin Dermatol. 2019 Jun; 20(3):335-344.AJ

Abstract

Acne vulgaris is a chronic skin disorder involving hair follicles and sebaceous glands. Multiple factors contribute to the disease, including skin microbes. The skin microbiome in the follicle is composed of a diverse group of microorganisms. Among them, Propionibacterium acnes and Malassezia spp. have been linked to acne development through their influence on sebum secretion, comedone formation, and inflammatory response. Antibiotics targeting P. acnes have been the mainstay in acne treatment for the past four decades. Among them, macrolides, clindamycin, and tetracyclines are the most widely prescribed. As antibiotic resistance becomes an increasing concern in clinical practice, understanding the skin microbiome associated with acne and the effects of antibiotic use on the skin commensals is highly relevant and critical to clinicians. In this review, we summarize recent studies of the composition and dynamics of the skin microbiome in acne and the effects of antibiotic treatment on skin microbes.

Authors+Show Affiliations

Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, 4339 CNSI, 570 Westwood Plaza, Building 114, Los Angeles, CA, 90095, USA. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, 4339 CNSI, 570 Westwood Plaza, Building 114, Los Angeles, CA, 90095, USA. huiying@ucla.edu. UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA, USA. huiying@ucla.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30632097

Citation

Xu, Haoxiang, and Huiying Li. "Acne, the Skin Microbiome, and Antibiotic Treatment." American Journal of Clinical Dermatology, vol. 20, no. 3, 2019, pp. 335-344.
Xu H, Li H. Acne, the Skin Microbiome, and Antibiotic Treatment. Am J Clin Dermatol. 2019;20(3):335-344.
Xu, H., & Li, H. (2019). Acne, the Skin Microbiome, and Antibiotic Treatment. American Journal of Clinical Dermatology, 20(3), 335-344. https://doi.org/10.1007/s40257-018-00417-3
Xu H, Li H. Acne, the Skin Microbiome, and Antibiotic Treatment. Am J Clin Dermatol. 2019;20(3):335-344. PubMed PMID: 30632097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acne, the Skin Microbiome, and Antibiotic Treatment. AU - Xu,Haoxiang, AU - Li,Huiying, PY - 2019/1/12/pubmed PY - 2019/11/26/medline PY - 2019/1/12/entrez SP - 335 EP - 344 JF - American journal of clinical dermatology JO - Am J Clin Dermatol VL - 20 IS - 3 N2 - Acne vulgaris is a chronic skin disorder involving hair follicles and sebaceous glands. Multiple factors contribute to the disease, including skin microbes. The skin microbiome in the follicle is composed of a diverse group of microorganisms. Among them, Propionibacterium acnes and Malassezia spp. have been linked to acne development through their influence on sebum secretion, comedone formation, and inflammatory response. Antibiotics targeting P. acnes have been the mainstay in acne treatment for the past four decades. Among them, macrolides, clindamycin, and tetracyclines are the most widely prescribed. As antibiotic resistance becomes an increasing concern in clinical practice, understanding the skin microbiome associated with acne and the effects of antibiotic use on the skin commensals is highly relevant and critical to clinicians. In this review, we summarize recent studies of the composition and dynamics of the skin microbiome in acne and the effects of antibiotic treatment on skin microbes. SN - 1179-1888 UR - https://www.unboundmedicine.com/medline/citation/30632097/Acne_the_Skin_Microbiome_and_Antibiotic_Treatment_ L2 - https://dx.doi.org/10.1007/s40257-018-00417-3 DB - PRIME DP - Unbound Medicine ER -