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Anterior segment optical coherence tomography (AS-OCT) as a new method of detecting copper deposits forming the Kayser-Fleischer ring in patients with Wilson disease.
Acta Ophthalmol 2019; 97(5):e757-e760AO

Abstract

PURPOSE

Kayser-Fleischer ring pathognomonic for Wilson disease (WD) is formed of corneal copper deposits present predominantly within the anterior chamber angle at the Schwalbe's line. The slit-lamp assessment commonly used as a standard of care cannot detect them early enough, as the angle view is obscured by the corneal limbus. The aim of the research was to evaluate the anterior segment optical coherence tomography (AS-OCT), as objective diagnostic assessment of copper deposits forming KF ring in patients with WD.

METHODS

Twenty-nine subjects (17 women) and twenty-nine controls (14 women) were enrolled and underwent slit lamp and AS-OCT assessment.

RESULTS

Kayser-Fleischer ring was not detected - either with a slit lamp or with AS-OCT - in any of the controls. Fifteen subjects presenting without KF ring at a slit-lamp examination were found to have a KF ring when examined with AS-OCT (p < 0.001), which confirms improved accuracy of AS-OCT, as compared to the slit-lamp examination.

CONCLUSION

Our results support AS-OCT as a diagnostic procedure to offer better objectivity and accuracy as compared to a slit-lamp examination, both at the diagnostic stage and when monitoring changes in KF ring during medical therapy to assess its efficacy and patient compliance.

Authors+Show Affiliations

SPKSO Ophthalmic University Hospital, Medical University of Warsaw, Warsaw, Poland.2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland. Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland.SPKSO Ophthalmic University Hospital, Medical University of Warsaw, Warsaw, Poland. Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30635971

Citation

Broniek-Kowalik, Karina, et al. "Anterior Segment Optical Coherence Tomography (AS-OCT) as a New Method of Detecting Copper Deposits Forming the Kayser-Fleischer Ring in Patients With Wilson Disease." Acta Ophthalmologica, vol. 97, no. 5, 2019, pp. e757-e760.
Broniek-Kowalik K, Dzieżyc K, Litwin T, et al. Anterior segment optical coherence tomography (AS-OCT) as a new method of detecting copper deposits forming the Kayser-Fleischer ring in patients with Wilson disease. Acta Ophthalmol. 2019;97(5):e757-e760.
Broniek-Kowalik, K., Dzieżyc, K., Litwin, T., Członkowska, A., & Szaflik, J. P. (2019). Anterior segment optical coherence tomography (AS-OCT) as a new method of detecting copper deposits forming the Kayser-Fleischer ring in patients with Wilson disease. Acta Ophthalmologica, 97(5), pp. e757-e760. doi:10.1111/aos.14009.
Broniek-Kowalik K, et al. Anterior Segment Optical Coherence Tomography (AS-OCT) as a New Method of Detecting Copper Deposits Forming the Kayser-Fleischer Ring in Patients With Wilson Disease. Acta Ophthalmol. 2019;97(5):e757-e760. PubMed PMID: 30635971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anterior segment optical coherence tomography (AS-OCT) as a new method of detecting copper deposits forming the Kayser-Fleischer ring in patients with Wilson disease. AU - Broniek-Kowalik,Karina, AU - Dzieżyc,Karolina, AU - Litwin,Tomasz, AU - Członkowska,Anna, AU - Szaflik,Jacek P, Y1 - 2019/01/11/ PY - 2018/02/23/received PY - 2018/12/09/accepted PY - 2019/1/13/pubmed PY - 2019/7/19/medline PY - 2019/1/13/entrez KW - Kayser-Fleischer ring KW - Wilson disease KW - anterior segment optical coherence tomography KW - copper deposit SP - e757 EP - e760 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 97 IS - 5 N2 - PURPOSE: Kayser-Fleischer ring pathognomonic for Wilson disease (WD) is formed of corneal copper deposits present predominantly within the anterior chamber angle at the Schwalbe's line. The slit-lamp assessment commonly used as a standard of care cannot detect them early enough, as the angle view is obscured by the corneal limbus. The aim of the research was to evaluate the anterior segment optical coherence tomography (AS-OCT), as objective diagnostic assessment of copper deposits forming KF ring in patients with WD. METHODS: Twenty-nine subjects (17 women) and twenty-nine controls (14 women) were enrolled and underwent slit lamp and AS-OCT assessment. RESULTS: Kayser-Fleischer ring was not detected - either with a slit lamp or with AS-OCT - in any of the controls. Fifteen subjects presenting without KF ring at a slit-lamp examination were found to have a KF ring when examined with AS-OCT (p < 0.001), which confirms improved accuracy of AS-OCT, as compared to the slit-lamp examination. CONCLUSION: Our results support AS-OCT as a diagnostic procedure to offer better objectivity and accuracy as compared to a slit-lamp examination, both at the diagnostic stage and when monitoring changes in KF ring during medical therapy to assess its efficacy and patient compliance. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/30635971/Anterior_segment_optical_coherence_tomography__AS_OCT__as_a_new_method_of_detecting_copper_deposits_forming_the_Kayser_Fleischer_ring_in_patients_with_Wilson_disease_ L2 - https://doi.org/10.1111/aos.14009 DB - PRIME DP - Unbound Medicine ER -