Abstract
BACKGROUND AND OBJECTIVE
Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries.The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients.
METHODS
The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients' clinical data were compared with histological findings.
RESULTS
Androgenetic alopecia (AGA) was the most common subtype followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections.
CONCLUSION
Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable.
TY - JOUR
T1 - Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts.
AU - Sari Aslani,Fatemeh,
AU - Heidari Esfahani,Mina,
AU - Sepaskhah,Mozhdeh,
Y1 - 2018/09/12/
PY - 2017/02/13/received
PY - 2018/08/18/accepted
PY - 2019/1/15/entrez
PY - 2019/1/15/pubmed
PY - 2019/1/15/medline
KW - Alopecia
KW - Alopecia areata
KW - Androgenetic alopecia
KW - Biopsy
KW - Iran
KW - Pathology
KW - Scalp
SP - 317
EP - 324
JF - Iranian journal of pathology
JO - Iran J Pathol
VL - 13
IS - 3
N2 - BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries.The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients' clinical data were compared with histological findings. RESULTS: Androgenetic alopecia (AGA) was the most common subtype followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections. CONCLUSION: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable.
SN - 1735-5303
UR - https://www.unboundmedicine.com/medline/citation/30636954/Non_scarring_Alopecias_in_Iranian_Patients:_A_Histopathological_Study_With_Hair_Counts_
DB - PRIME
DP - Unbound Medicine
ER -
