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A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC- and CBD-acids.
Forensic Sci Int. 2019 Feb; 295:207-212.FS

Abstract

Highly potent cannabis concentrates obtained by butane or by supercritical carbon dioxide-extraction are gaining popularity. These extracts called butane hash oil (BHO) with Δ9-tetrahydrocannabinolic acid A (THCA) contents above 60% are consumed by flash vaporization on a glowing titanium nail, followed by inhalation of the resulting vapor through a water pipe in a single puff - a technique referred to as "dabbing". We herein investigated the decarboxylation rate of THCA during artificial smoking of cannabis plant material and simulated dabbing, and the lung availability of Δ9-tetrahydrocannabinol (THC) which we define as the recovery of THC in the smoke and vapor condensates. Preliminary smoking and dabbing experiments were performed using an apparatus built in-house. Due to availability of cannabidiol (CBD)-rich hemp in Switzerland, we included a sample of CBD flowers in our experiments and investigated the decarboxylation and recovery of cannabidiolic acid (CBDA) and CBD, respectively. Decarboxylation of THCA and CBDA during combustion of the plant material and vaporization of the BHO, respectively, was complete. The high recovery of total THC (75.5%) by dabbing cannot be achieved by smoking marijuana. Lung availability ranged from 12% for mixed cannabis material with a rather low THC content, to approximately 19-27% for marijuana flowers, similar for THC in marijuana as for CBD in CBD-rich marijuana. In reality, when smoking a joint, further losses in recovery must be assumed by additional sidestream smoke. The rather high lung availability of THC via dabbing can explain the increased psychoactive and adverse effects associated with this new trend of cannabis consumption.

Authors+Show Affiliations

Institute of Forensic Medicine, Department of Forensic Toxicology and Chemistry, University of Bern, Bühlstrasse 20, 3012, Bern, Switzerland.Heinrich-Heine University, Universitätsstrasse 1, 40225, Düsseldorf, Germany; Landeskriminalamt Nordrhein-Westfalen, KTI - Teildezernat 51.2 Betäubungsmittel, Völklinger Strasse 49, 40221, Düsseldorf, Germany.Institute of Forensic Medicine, Department of Forensic Toxicology and Chemistry, University of Bern, Bühlstrasse 20, 3012, Bern, Switzerland. Electronic address: wolfgang.weinmann@irm.unibe.ch.Landeskriminalamt Nordrhein-Westfalen, KTI - Teildezernat 51.2 Betäubungsmittel, Völklinger Strasse 49, 40221, Düsseldorf, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30638755

Citation

Hädener, Marianne, et al. "A Preliminary Investigation of Lung Availability of Cannabinoids By Smoking Marijuana or Dabbing BHO and Decarboxylation Rate of THC- and CBD-acids." Forensic Science International, vol. 295, 2019, pp. 207-212.
Hädener M, Vieten S, Weinmann W, et al. A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC- and CBD-acids. Forensic Sci Int. 2019;295:207-212.
Hädener, M., Vieten, S., Weinmann, W., & Mahler, H. (2019). A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC- and CBD-acids. Forensic Science International, 295, 207-212. https://doi.org/10.1016/j.forsciint.2018.12.021
Hädener M, et al. A Preliminary Investigation of Lung Availability of Cannabinoids By Smoking Marijuana or Dabbing BHO and Decarboxylation Rate of THC- and CBD-acids. Forensic Sci Int. 2019;295:207-212. PubMed PMID: 30638755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC- and CBD-acids. AU - Hädener,Marianne, AU - Vieten,Sina, AU - Weinmann,Wolfgang, AU - Mahler,Hellmut, Y1 - 2019/01/06/ PY - 2018/10/02/received PY - 2018/12/28/revised PY - 2018/12/31/accepted PY - 2019/1/15/pubmed PY - 2019/2/23/medline PY - 2019/1/15/entrez KW - BHO KW - Cannabis concentrate KW - Dabbing KW - Lung availability KW - Marijuana SP - 207 EP - 212 JF - Forensic science international JO - Forensic Sci Int VL - 295 N2 - Highly potent cannabis concentrates obtained by butane or by supercritical carbon dioxide-extraction are gaining popularity. These extracts called butane hash oil (BHO) with Δ9-tetrahydrocannabinolic acid A (THCA) contents above 60% are consumed by flash vaporization on a glowing titanium nail, followed by inhalation of the resulting vapor through a water pipe in a single puff - a technique referred to as "dabbing". We herein investigated the decarboxylation rate of THCA during artificial smoking of cannabis plant material and simulated dabbing, and the lung availability of Δ9-tetrahydrocannabinol (THC) which we define as the recovery of THC in the smoke and vapor condensates. Preliminary smoking and dabbing experiments were performed using an apparatus built in-house. Due to availability of cannabidiol (CBD)-rich hemp in Switzerland, we included a sample of CBD flowers in our experiments and investigated the decarboxylation and recovery of cannabidiolic acid (CBDA) and CBD, respectively. Decarboxylation of THCA and CBDA during combustion of the plant material and vaporization of the BHO, respectively, was complete. The high recovery of total THC (75.5%) by dabbing cannot be achieved by smoking marijuana. Lung availability ranged from 12% for mixed cannabis material with a rather low THC content, to approximately 19-27% for marijuana flowers, similar for THC in marijuana as for CBD in CBD-rich marijuana. In reality, when smoking a joint, further losses in recovery must be assumed by additional sidestream smoke. The rather high lung availability of THC via dabbing can explain the increased psychoactive and adverse effects associated with this new trend of cannabis consumption. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/30638755/A_preliminary_investigation_of_lung_availability_of_cannabinoids_by_smoking_marijuana_or_dabbing_BHO_and_decarboxylation_rate_of_THC__and_CBD_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(18)30847-8 DB - PRIME DP - Unbound Medicine ER -