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Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model.
Brain Res Bull. 2019 03; 146:192-200.BR

Abstract

Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG), which produces remarkable analgesia through high-frequency electromagnetic energy, has become a main therapy for chronic neuropathic pain. The chronic neuropathic pain in patients is frequently accompanied by depression. However, the underlying neurophysiological mechanisms of the treatment of PRF on DRG for the neuropathic pain-induced depression remain unclear. This study was designed to explore the effect of PRF on DRG on the neuropathic pain-induced depression in rats with spared nerve injury (SNI). Here, we found that PRF on DRG or intrathecal injection of the interferon regulatory factor 8 (IRF8) siRNA prevented the increase of mechanical allodynia and depression-like behaviors of rats after receiving SNI. Meanwhile, Western blot, immunohistochemistry, and RT-PCR revealed that PRF on DRG or intrathecal injection of IRF8 siRNA inhibited IRF8 overexpression in the spinal cord and brain-derived neurotrophic factor (BDNF) in NAc. These results suggest that neuropathic pain-induced depression could be attenuated by PRF applied to DRG in SNI rats. The suppressed overexpression of the spinal IRF8 and BDNF in NAc may play an important role and contribute considerably to effectiveness of the therapy by PRF on DRG.

Authors+Show Affiliations

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.Department of Pain Management, Fujian Key Laboratory of Geriatrics, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, Fujian, China.Department of Pain Management, Fujian Key Laboratory of Geriatrics, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, Fujian, China.Department of Pain Management, Fujian Key Laboratory of Geriatrics, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, Fujian, China. Electronic address: lrgfw88@sina.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30639279

Citation

Fang, Xiangyu, et al. "Downregulated Spinal IRF8 and BDNF in NAC Are Involved in Neuropathic Pain-induced Depression Relief Via Pulsed Radiofrequency On Dorsal Root Ganglion in Rat SNI Model." Brain Research Bulletin, vol. 146, 2019, pp. 192-200.
Fang X, Xu X, Lin X, et al. Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model. Brain Res Bull. 2019;146:192-200.
Fang, X., Xu, X., Lin, X., & Liu, R. (2019). Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model. Brain Research Bulletin, 146, 192-200. https://doi.org/10.1016/j.brainresbull.2019.01.008
Fang X, et al. Downregulated Spinal IRF8 and BDNF in NAC Are Involved in Neuropathic Pain-induced Depression Relief Via Pulsed Radiofrequency On Dorsal Root Ganglion in Rat SNI Model. Brain Res Bull. 2019;146:192-200. PubMed PMID: 30639279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model. AU - Fang,Xiangyu, AU - Xu,Xueru, AU - Lin,Xingwu, AU - Liu,Rongguo, Y1 - 2019/01/09/ PY - 2018/11/03/received PY - 2018/12/10/revised PY - 2019/01/06/accepted PY - 2019/1/15/pubmed PY - 2020/3/11/medline PY - 2019/1/15/entrez KW - Brain-derived neurotrophic factor KW - Depression KW - Dorsal root ganglion KW - Interferon regulatory factor 8 KW - Neuropathic pain KW - Pulsed radiofrequency SP - 192 EP - 200 JF - Brain research bulletin JO - Brain Res Bull VL - 146 N2 - Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG), which produces remarkable analgesia through high-frequency electromagnetic energy, has become a main therapy for chronic neuropathic pain. The chronic neuropathic pain in patients is frequently accompanied by depression. However, the underlying neurophysiological mechanisms of the treatment of PRF on DRG for the neuropathic pain-induced depression remain unclear. This study was designed to explore the effect of PRF on DRG on the neuropathic pain-induced depression in rats with spared nerve injury (SNI). Here, we found that PRF on DRG or intrathecal injection of the interferon regulatory factor 8 (IRF8) siRNA prevented the increase of mechanical allodynia and depression-like behaviors of rats after receiving SNI. Meanwhile, Western blot, immunohistochemistry, and RT-PCR revealed that PRF on DRG or intrathecal injection of IRF8 siRNA inhibited IRF8 overexpression in the spinal cord and brain-derived neurotrophic factor (BDNF) in NAc. These results suggest that neuropathic pain-induced depression could be attenuated by PRF applied to DRG in SNI rats. The suppressed overexpression of the spinal IRF8 and BDNF in NAc may play an important role and contribute considerably to effectiveness of the therapy by PRF on DRG. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/30639279/Downregulated_spinal_IRF8_and_BDNF_in_NAC_are_involved_in_neuropathic_pain_induced_depression_relief_via_pulsed_radiofrequency_on_dorsal_root_ganglion_in_rat_SNI_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(18)30847-5 DB - PRIME DP - Unbound Medicine ER -