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Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study.
Lung Cancer. 2019 02; 128:57-66.LC

Abstract

OBJECTIVES

Nut consumption has been associated with reduced cancer-related mortality, but evidence for a relation between nut intake and lung cancer risk is limited. We investigated the association between total nut, tree nut, peanut, and peanut butter intake and the risk of lung cancer and its subtypes in the Netherlands Cohort Study.

MATERIALS AND METHODS

In 1986, dietary and lifestyle habits of 120,852 participants, aged 55-69 years, were measured with a questionnaire. After 20.3 years of follow-up, 3720 subcohort members and 2861 lung cancer cases were included in multivariable case-cohort analyses.

RESULTS

Total nut intake was not significantly associated with total lung cancer risk in men or women. For small cell carcinoma, a significant inverse association with total nut intake was observed in men after controlling for detailed smoking habits (HR (95%CI) for 10+ g/day vs. nonconsumers: 0.62 (0.43-0.89), p-trend: 0.024). Inverse relations with small cell carcinoma were also found for tree nut and peanut intake in men in continuous analyses (HR (95%CI) per 5 g/day increment: 0.70 (0.53-0.93) and 0.93 (0.88-0.98), respectively). For the other lung cancer subtypes, no significant associations were seen in men. Nut intake was not related to the risk of lung cancer subtypes in women, and no associations were found for peanut butter in both sexes.

CONCLUSION

Increased nut intake might contribute to the prevention of small cell carcinoma in men. No significant associations were found in men for the other subtypes or total lung cancer, in women, or for peanut butter intake.

Authors+Show Affiliations

Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address: l.nieuwenhuis@maastrichtuniversity.nl.Department of Epidemiology, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Center+, Maastricht, the Netherlands; Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, the Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30642454

Citation

Nieuwenhuis, Lisette, and Piet A. van den Brandt. "Nut and Peanut Butter Consumption and the Risk of Lung Cancer and Its Subtypes: a Prospective Cohort Study." Lung Cancer (Amsterdam, Netherlands), vol. 128, 2019, pp. 57-66.
Nieuwenhuis L, van den Brandt PA. Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study. Lung Cancer. 2019;128:57-66.
Nieuwenhuis, L., & van den Brandt, P. A. (2019). Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study. Lung Cancer (Amsterdam, Netherlands), 128, 57-66. https://doi.org/10.1016/j.lungcan.2018.12.018
Nieuwenhuis L, van den Brandt PA. Nut and Peanut Butter Consumption and the Risk of Lung Cancer and Its Subtypes: a Prospective Cohort Study. Lung Cancer. 2019;128:57-66. PubMed PMID: 30642454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study. AU - Nieuwenhuis,Lisette, AU - van den Brandt,Piet A, Y1 - 2018/12/18/ PY - 2018/09/13/received PY - 2018/12/12/revised PY - 2018/12/17/accepted PY - 2019/1/16/entrez PY - 2019/1/16/pubmed PY - 2019/12/21/medline KW - Cohort studies KW - Lung cancer KW - Nuts KW - Peanut butter KW - Peanuts KW - Prevention SP - 57 EP - 66 JF - Lung cancer (Amsterdam, Netherlands) JO - Lung Cancer VL - 128 N2 - OBJECTIVES: Nut consumption has been associated with reduced cancer-related mortality, but evidence for a relation between nut intake and lung cancer risk is limited. We investigated the association between total nut, tree nut, peanut, and peanut butter intake and the risk of lung cancer and its subtypes in the Netherlands Cohort Study. MATERIALS AND METHODS: In 1986, dietary and lifestyle habits of 120,852 participants, aged 55-69 years, were measured with a questionnaire. After 20.3 years of follow-up, 3720 subcohort members and 2861 lung cancer cases were included in multivariable case-cohort analyses. RESULTS: Total nut intake was not significantly associated with total lung cancer risk in men or women. For small cell carcinoma, a significant inverse association with total nut intake was observed in men after controlling for detailed smoking habits (HR (95%CI) for 10+ g/day vs. nonconsumers: 0.62 (0.43-0.89), p-trend: 0.024). Inverse relations with small cell carcinoma were also found for tree nut and peanut intake in men in continuous analyses (HR (95%CI) per 5 g/day increment: 0.70 (0.53-0.93) and 0.93 (0.88-0.98), respectively). For the other lung cancer subtypes, no significant associations were seen in men. Nut intake was not related to the risk of lung cancer subtypes in women, and no associations were found for peanut butter in both sexes. CONCLUSION: Increased nut intake might contribute to the prevention of small cell carcinoma in men. No significant associations were found in men for the other subtypes or total lung cancer, in women, or for peanut butter intake. SN - 1872-8332 UR - https://www.unboundmedicine.com/medline/citation/30642454/Nut_and_peanut_butter_consumption_and_the_risk_of_lung_cancer_and_its_subtypes:_A_prospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0169-5002(18)30715-3 DB - PRIME DP - Unbound Medicine ER -