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SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ.
Biochem Biophys Res Commun. 2019 02 19; 509(4):869-876.BB

Abstract

The Notch signaling pathway is highly conserved, involved in cell-cell communication, and essential for multicellular organism development. The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) transcriptional regulator plays a vital role in Notch signaling. When not complexed with Notch proteins, RBPJ acts as a transcriptional repressor. However, when bound to the Notch intracellular domain (NOTCH ICD) in the nucleus, RBPJ activates the transcription of Notch target genes. However, the role of RBPJ in the Notch signaling pathway in neuroblastoma (NB) remains unclear. In this study, we show that SNW domain containing 1 (SNW1) acts as a novel RBPJ partner and regulates the expression of Notch target genes. Additionally, we show that silencing RBPJ expression can prevent SNW1-mediated Notch gene expression. Public datasets and clinical NB tissues indicate that RBPJ and SNW1 are upregulated in NB, and are associated with unfavorable patient outcomes. Taken together, our results highlight that SNW1 interacts with RBPJ to regulate the Notch signaling pathway and presents a potential therapeutic target for NB.

Authors+Show Affiliations

Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: Wang9377@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30642633

Citation

Hong, Mei, et al. "SNW1 Regulates Notch Signaling in Neuroblastoma Through Interacting With RBPJ." Biochemical and Biophysical Research Communications, vol. 509, no. 4, 2019, pp. 869-876.
Hong M, He J, Li S. SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ. Biochem Biophys Res Commun. 2019;509(4):869-876.
Hong, M., He, J., & Li, S. (2019). SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ. Biochemical and Biophysical Research Communications, 509(4), 869-876. https://doi.org/10.1016/j.bbrc.2019.01.036
Hong M, He J, Li S. SNW1 Regulates Notch Signaling in Neuroblastoma Through Interacting With RBPJ. Biochem Biophys Res Commun. 2019 02 19;509(4):869-876. PubMed PMID: 30642633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ. AU - Hong,Mei, AU - He,Jing, AU - Li,Shiwang, Y1 - 2019/01/12/ PY - 2018/12/24/received PY - 2019/01/07/accepted PY - 2019/1/16/pubmed PY - 2019/11/8/medline PY - 2019/1/16/entrez KW - Interaction KW - Neuroblastoma KW - Notch signaling KW - RBPJ KW - SNW1 SP - 869 EP - 876 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 509 IS - 4 N2 - The Notch signaling pathway is highly conserved, involved in cell-cell communication, and essential for multicellular organism development. The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) transcriptional regulator plays a vital role in Notch signaling. When not complexed with Notch proteins, RBPJ acts as a transcriptional repressor. However, when bound to the Notch intracellular domain (NOTCH ICD) in the nucleus, RBPJ activates the transcription of Notch target genes. However, the role of RBPJ in the Notch signaling pathway in neuroblastoma (NB) remains unclear. In this study, we show that SNW domain containing 1 (SNW1) acts as a novel RBPJ partner and regulates the expression of Notch target genes. Additionally, we show that silencing RBPJ expression can prevent SNW1-mediated Notch gene expression. Public datasets and clinical NB tissues indicate that RBPJ and SNW1 are upregulated in NB, and are associated with unfavorable patient outcomes. Taken together, our results highlight that SNW1 interacts with RBPJ to regulate the Notch signaling pathway and presents a potential therapeutic target for NB. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/30642633/SNW1_regulates_Notch_signaling_in_neuroblastoma_through_interacting_with_RBPJ_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(19)30044-0 DB - PRIME DP - Unbound Medicine ER -