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Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma.
World J Gastroenterol 2019; 25(1):42-58WJ

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer, and hepatitis C virus (HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), Wnt/β-catenin (WNT), cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor α (PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC.

Authors+Show Affiliations

Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran.Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran.The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514633341, Iran.The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514633341, Iran. f.farshadpour@bpums.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30643357

Citation

Mahmoudvand, Shahab, et al. "Hepatitis C Virus Core Protein Modulates Several Signaling Pathways Involved in Hepatocellular Carcinoma." World Journal of Gastroenterology, vol. 25, no. 1, 2019, pp. 42-58.
Mahmoudvand S, Shokri S, Taherkhani R, et al. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World J Gastroenterol. 2019;25(1):42-58.
Mahmoudvand, S., Shokri, S., Taherkhani, R., & Farshadpour, F. (2019). Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. World Journal of Gastroenterology, 25(1), pp. 42-58. doi:10.3748/wjg.v25.i1.42.
Mahmoudvand S, et al. Hepatitis C Virus Core Protein Modulates Several Signaling Pathways Involved in Hepatocellular Carcinoma. World J Gastroenterol. 2019 Jan 7;25(1):42-58. PubMed PMID: 30643357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma. AU - Mahmoudvand,Shahab, AU - Shokri,Somayeh, AU - Taherkhani,Reza, AU - Farshadpour,Fatemeh, PY - 2018/10/19/received PY - 2018/12/07/revised PY - 2018/12/13/accepted PY - 2019/1/16/entrez PY - 2019/1/16/pubmed PY - 2019/1/29/medline KW - Core protein KW - Cyclooxygenase-2 KW - Hepatitis C virus KW - Hepatocellular carcinoma KW - Peroxisome proliferator-activated receptor α KW - Transforming growth factor β KW - Vascular endothelial growth factor KW - Wnt/β-catenin SP - 42 EP - 58 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 25 IS - 1 N2 - Hepatocellular carcinoma (HCC) is the fifth most common cancer, and hepatitis C virus (HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), Wnt/β-catenin (WNT), cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor α (PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/30643357/Hepatitis_C_virus_core_protein_modulates_several_signaling_pathways_involved_in_hepatocellular_carcinoma_ L2 - http://www.wjgnet.com/1007-9327/full/v25/i1/42.htm DB - PRIME DP - Unbound Medicine ER -