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Light-microscopic assessment of 100 patients with patch/plaque-stage mycosis fungoides.
Am J Dermatopathol 1988; 10(6):469-77AJ

Abstract

The light-microscopic recognition of patch/plaque stages of mycosis fungoides is difficult, but remains as the "gold standard" for the diagnosis of mycosis fungoides (MF). A review of previous publications concerning the light-microscopic histological criteria for recognition of MF is followed by a summary of our recent histological findings involving 100 patients. The quantitative histological assessment included 13 different parameters for each case of patch/plaque-stage disease. The different criteria included parakeratosis, acanthosis, density of upper dermal mononuclear cell infiltrate, degree of lymphocyte atypia, degree of epidermotropism, Pautrier microabscess formation, band-like pattern, presence of basal vacuolar change, spongiosis, papillary dermal fibrosis, presence of eosinophils, and presence of plasma cells. The most significant histological features of patch/plaque-stage MF are: 1. Broad zones of epidermis in which lymphocytes, which are usually not markedly atypical, are in close apposition to basal and lower-level keratinocytes predominantly as single cells in a somewhat linear configuration on the epidermal side of the dermal-epidermal junction. In general, the surrounding keratinocytes do not display any cytopathic changes, i.e., basal vacuolar degeneration or apoptosis. 2. The papillary dermis contains a variably dense mono-nuclear cell infiltrate that is usually polymorphous and in which there is papillary dermal fibrosis with plasma cells and eosinophils. 3. Pautrier microabscesses are only present in the minority of cases of MF. Representative "threshold" cases of the earliest recognizable diagnostic cases of MF are illustrated. A pragmatic diagnostic approach to patients presenting with a clinical picture suggesting MF is outlined. The potential usefulness of additional ancillary diagnostic techniques such as immunoperoxidase frozen-section stains and T-cell-receptor gene rearrangements are briefly reviewed.

Authors+Show Affiliations

Department of Pathology, University of Michigan Medical School, Ann Arbor 48109-0602.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

3064629

Citation

Nickoloff, B J.. "Light-microscopic Assessment of 100 Patients With Patch/plaque-stage Mycosis Fungoides." The American Journal of Dermatopathology, vol. 10, no. 6, 1988, pp. 469-77.
Nickoloff BJ. Light-microscopic assessment of 100 patients with patch/plaque-stage mycosis fungoides. Am J Dermatopathol. 1988;10(6):469-77.
Nickoloff, B. J. (1988). Light-microscopic assessment of 100 patients with patch/plaque-stage mycosis fungoides. The American Journal of Dermatopathology, 10(6), pp. 469-77.
Nickoloff BJ. Light-microscopic Assessment of 100 Patients With Patch/plaque-stage Mycosis Fungoides. Am J Dermatopathol. 1988;10(6):469-77. PubMed PMID: 3064629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light-microscopic assessment of 100 patients with patch/plaque-stage mycosis fungoides. A1 - Nickoloff,B J, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 469 EP - 77 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 10 IS - 6 N2 - The light-microscopic recognition of patch/plaque stages of mycosis fungoides is difficult, but remains as the "gold standard" for the diagnosis of mycosis fungoides (MF). A review of previous publications concerning the light-microscopic histological criteria for recognition of MF is followed by a summary of our recent histological findings involving 100 patients. The quantitative histological assessment included 13 different parameters for each case of patch/plaque-stage disease. The different criteria included parakeratosis, acanthosis, density of upper dermal mononuclear cell infiltrate, degree of lymphocyte atypia, degree of epidermotropism, Pautrier microabscess formation, band-like pattern, presence of basal vacuolar change, spongiosis, papillary dermal fibrosis, presence of eosinophils, and presence of plasma cells. The most significant histological features of patch/plaque-stage MF are: 1. Broad zones of epidermis in which lymphocytes, which are usually not markedly atypical, are in close apposition to basal and lower-level keratinocytes predominantly as single cells in a somewhat linear configuration on the epidermal side of the dermal-epidermal junction. In general, the surrounding keratinocytes do not display any cytopathic changes, i.e., basal vacuolar degeneration or apoptosis. 2. The papillary dermis contains a variably dense mono-nuclear cell infiltrate that is usually polymorphous and in which there is papillary dermal fibrosis with plasma cells and eosinophils. 3. Pautrier microabscesses are only present in the minority of cases of MF. Representative "threshold" cases of the earliest recognizable diagnostic cases of MF are illustrated. A pragmatic diagnostic approach to patients presenting with a clinical picture suggesting MF is outlined. The potential usefulness of additional ancillary diagnostic techniques such as immunoperoxidase frozen-section stains and T-cell-receptor gene rearrangements are briefly reviewed. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/3064629/Light-microscopic_assessment_of_100_patients_with_patch/plaque-stage_mycosis_fungoides L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3064629.ui DB - PRIME DP - Unbound Medicine ER -