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Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016.
BMC Public Health. 2019 Jan 15; 19(1):69.BP

Abstract

BACKGROUND

In 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 2017. We report four years of data on rotavirus gastroenteritis in hospitalized children < 5 years of age prior to vaccine introduction.

METHODS

Children from 7 sites in southern and northern India hospitalized for diarrhoea were recruited between July 2012 and June 2016. Stool samples were screened for rotavirus using enzyme immunoassay (EIA). The EIA positive samples were genotyped by reverse-transcription polymerase chain reaction.

RESULTS

Of the 5834 samples from the 7 sites, 2069 (35.5%) were positive for rotavirus by EIA. Genotyping was performed for 2010 (97.1%) samples. G1P[8](56.3%), G2P[4](9.1%), G9P[4](7.6%), G9P[8](4.2%), and G12P[6](3.7%) were the common genotypes in southern India and G1P[8](36%), G9P[4](11.4%), G2P[4](11.2%), G12P[6](8.4%), and G3P[8](5.9%) in northern India.

CONCLUSIONS

The study highlights the high prevalence of rotavirus gastroenteritis in India and the diversity of rotavirus genotypes across different geographical regions. Pre- vaccine surveillance data is necessary to evaluate the potential change in admission rates for gastroenteritis and circulating rotavirus genotypes after vaccine introduction, thus assessing impact.

Authors+Show Affiliations

Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.Department of Paediatrics, St. Stephen's Hospital, Tis Hazari, New Delhi, India.Department of Paediatrics, SV Medical College, Tirupati, Andhra Pradesh, India.Department of Paediatrics, Christian Medical College, Vellore, Tamil Nadu, India.Department of Paediatrics, Christian Medical College, Ludhiana, Punjab, India.Punjagutta, Pragna Hospital, Hyderabad, Telangana, India.Department of Paediatrics, Malankara Orthodox Syrian Church Medical College, Kolenchery, Kerala, India.Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.Indian Council of Medical Research, New Delhi, India. Present address: Translational Health Science and Technology Institute (THSTI), Faridabad, India.National Institute of Epidemiology, Chennai, Tamil Nadu, India.National Institute of Epidemiology, Chennai, Tamil Nadu, India.Indian Council of Medical Research, New Delhi, India.Indian Council of Medical Research, New Delhi, India.Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India. gkang@cmcvellore.ac.in. Present address: Translational Health Science and Technology Institute (THSTI), Faridabad, India. gkang@cmcvellore.ac.in.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30646867

Citation

Giri, Sidhartha, et al. "Rotavirus Gastroenteritis in Indian Children < 5 Years Hospitalized for Diarrhoea, 2012 to 2016." BMC Public Health, vol. 19, no. 1, 2019, p. 69.
Giri S, Nair NP, Mathew A, et al. Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016. BMC Public Health. 2019;19(1):69.
Giri, S., Nair, N. P., Mathew, A., Manohar, B., Simon, A., Singh, T., Suresh Kumar, S., Mathew, M. A., Babji, S., Arora, R., Girish Kumar, C. P., Venkatasubramanian, S., Mehendale, S., Gupte, M. D., & Kang, G. (2019). Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016. BMC Public Health, 19(1), 69. https://doi.org/10.1186/s12889-019-6406-0
Giri S, et al. Rotavirus Gastroenteritis in Indian Children < 5 Years Hospitalized for Diarrhoea, 2012 to 2016. BMC Public Health. 2019 Jan 15;19(1):69. PubMed PMID: 30646867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rotavirus gastroenteritis in Indian children < 5 years hospitalized for diarrhoea, 2012 to 2016. AU - Giri,Sidhartha, AU - Nair,Nayana P, AU - Mathew,Ann, AU - Manohar,B, AU - Simon,Anna, AU - Singh,Tejinder, AU - Suresh Kumar,S, AU - Mathew,M A, AU - Babji,Sudhir, AU - Arora,Rashmi, AU - Girish Kumar,C P, AU - Venkatasubramanian,S, AU - Mehendale,Sanjay, AU - Gupte,Mohan D, AU - Kang,Gagandeep, Y1 - 2019/01/15/ PY - 2018/07/20/received PY - 2019/01/07/accepted PY - 2019/1/17/entrez PY - 2019/1/17/pubmed PY - 2019/2/20/medline KW - Diarrhoea KW - Enzyme immunoassay KW - Gastroenteritis KW - Genotypes KW - India KW - Polymerase chain reaction KW - Rotavirus SP - 69 EP - 69 JF - BMC public health JO - BMC Public Health VL - 19 IS - 1 N2 - BACKGROUND: In 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 2017. We report four years of data on rotavirus gastroenteritis in hospitalized children < 5 years of age prior to vaccine introduction. METHODS: Children from 7 sites in southern and northern India hospitalized for diarrhoea were recruited between July 2012 and June 2016. Stool samples were screened for rotavirus using enzyme immunoassay (EIA). The EIA positive samples were genotyped by reverse-transcription polymerase chain reaction. RESULTS: Of the 5834 samples from the 7 sites, 2069 (35.5%) were positive for rotavirus by EIA. Genotyping was performed for 2010 (97.1%) samples. G1P[8](56.3%), G2P[4](9.1%), G9P[4](7.6%), G9P[8](4.2%), and G12P[6](3.7%) were the common genotypes in southern India and G1P[8](36%), G9P[4](11.4%), G2P[4](11.2%), G12P[6](8.4%), and G3P[8](5.9%) in northern India. CONCLUSIONS: The study highlights the high prevalence of rotavirus gastroenteritis in India and the diversity of rotavirus genotypes across different geographical regions. Pre- vaccine surveillance data is necessary to evaluate the potential change in admission rates for gastroenteritis and circulating rotavirus genotypes after vaccine introduction, thus assessing impact. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/30646867/Rotavirus_gastroenteritis_in_Indian_children_<_5_years_hospitalized_for_diarrhoea_2012_to_2016_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-6406-0 DB - PRIME DP - Unbound Medicine ER -