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IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease.
Arch Argent Pediatr. 2019 02 01; 117(1):52-55.AA

Abstract

OBJECTIVE

To compare the performance of IgA anti-tissue transglutaminase antibodies (IgA anti-tTG), IgA anti-endomysial antibodies (IgA EMA), and IgA/IgG antibodies against deamidated gliadin peptides (IgA/IgG anti-DGP) for the diagnosis of celiac disease.

METHODS

Descriptive study in patients with celiac disease. Anti-DGP (IgA/IgG), IgA EMA, IgA anti-tTG antibodies were measured and an intestinal biopsy was done. Sex: female (61 %). Median age: 78.4 months old.

RESULTS

A total of 136 children were included; 108 had high IgA anti-DGP titers; 124, increased IgG anti-DGP titers; 128, positive IgA EMA titers; and 130, increased IgA anti-tTG titers. High IgG anti-DGP titers were observed in 4/6 patients with negative IgA anti-tTG antibodies. The combination of IgG anti-DGP + IgA anti-tTG antibodies showed a positive correlation in 134 patients and the IgG anti-DGP + EMA combination was positive in 133 children.

CONCLUSION

IgA EMA, IgA anti-tTG, and IgG anti-DGP antibodies exhibited an adequate specificity and sensitivity. The IgG anti-DGP/anti-tTG combination showed a 98-99 % sensitivity and a 100 % specificity. The anti-tTG and IgG anti-DGP option yields excellent results, with a low cost and independence from the observer.

Authors+Show Affiliations

Sección de Gastroenterología, Hepatología y Nutrición Infantil, Servicio de Pediatría. ortizgonzalojavier@gmail.com.Sección de Gastroenterología, Hepatología y Nutrición Infantil, Servicio de Pediatría.Sección de Gastroenterología, Hepatología y Nutrición Infantil, Servicio de Pediatría.Servicio de Laboratorio. Hospital Nacional Alejandro Posadas.Sección de Gastroenterología, Hepatología y Nutrición Infantil, Servicio de Pediatría.Sección de Gastroenterología, Hepatología y Nutrición Infantil, Servicio de Pediatría.Sección de Gastroenterología, Hepatología y Nutrición Infantil, Servicio de Pediatría.

Pub Type(s)

Comparative Study
Journal Article
Observational Study

Language

eng spa

PubMed ID

30652447

Citation

Ortiz, Gonzalo, et al. "IgA Anti-tissue Transglutaminase Antibodies and IgG Antibodies Against Deamidated Gliadin Peptides as Predictors of Celiac Disease." Archivos Argentinos De Pediatria, vol. 117, no. 1, 2019, pp. 52-55.
Ortiz G, Messere G, Toca MDC, et al. IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease. Arch Argent Pediatr. 2019;117(1):52-55.
Ortiz, G., Messere, G., Toca, M. D. C., Fiorucci, M., Bigliardi, R., Vidal, J., & Reynoso, R. (2019). IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease. Archivos Argentinos De Pediatria, 117(1), 52-55. https://doi.org/10.5546/aap.2019.eng.52
Ortiz G, et al. IgA Anti-tissue Transglutaminase Antibodies and IgG Antibodies Against Deamidated Gliadin Peptides as Predictors of Celiac Disease. Arch Argent Pediatr. 2019 02 1;117(1):52-55. PubMed PMID: 30652447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease. AU - Ortiz,Gonzalo, AU - Messere,Gabriela, AU - Toca,María Del C, AU - Fiorucci,Mirian, AU - Bigliardi,Román, AU - Vidal,Jorge, AU - Reynoso,Ricardo, PY - 2017/09/06/received PY - 2018/08/15/accepted PY - 2019/1/18/entrez PY - 2019/1/18/pubmed PY - 2020/3/18/medline KW - Antibodies KW - Celiac disease KW - Children KW - Diagnosis SP - 52 EP - 55 JF - Archivos argentinos de pediatria JO - Arch Argent Pediatr VL - 117 IS - 1 N2 - OBJECTIVE: To compare the performance of IgA anti-tissue transglutaminase antibodies (IgA anti-tTG), IgA anti-endomysial antibodies (IgA EMA), and IgA/IgG antibodies against deamidated gliadin peptides (IgA/IgG anti-DGP) for the diagnosis of celiac disease. METHODS: Descriptive study in patients with celiac disease. Anti-DGP (IgA/IgG), IgA EMA, IgA anti-tTG antibodies were measured and an intestinal biopsy was done. Sex: female (61 %). Median age: 78.4 months old. RESULTS: A total of 136 children were included; 108 had high IgA anti-DGP titers; 124, increased IgG anti-DGP titers; 128, positive IgA EMA titers; and 130, increased IgA anti-tTG titers. High IgG anti-DGP titers were observed in 4/6 patients with negative IgA anti-tTG antibodies. The combination of IgG anti-DGP + IgA anti-tTG antibodies showed a positive correlation in 134 patients and the IgG anti-DGP + EMA combination was positive in 133 children. CONCLUSION: IgA EMA, IgA anti-tTG, and IgG anti-DGP antibodies exhibited an adequate specificity and sensitivity. The IgG anti-DGP/anti-tTG combination showed a 98-99 % sensitivity and a 100 % specificity. The anti-tTG and IgG anti-DGP option yields excellent results, with a low cost and independence from the observer. SN - 1668-3501 UR - https://www.unboundmedicine.com/medline/citation/30652447/IgA_anti_tissue_transglutaminase_antibodies_and_IgG_antibodies_against_deamidated_gliadin_peptides_as_predictors_of_celiac_disease_ L2 - https://doi.org/10.5546/aap.2019.eng.52 DB - PRIME DP - Unbound Medicine ER -