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SAPHO syndrome with pathological fractures of vertebral bodies: a case report.
BMC Musculoskelet Disord 2019; 20(1):27BM

Abstract

BACKGROUND

It's difficult to diagnose and treat synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome due to its rare and unknown pathogenesis. There is no effective treatment for SAPHO syndrome and the consequences of empirical treatment are unpredictable. This study reports a case of a young female diagnosed as SAPHO syndrome with pathological fractures of vertebral bodies.

CASE PRESENTATION

A 29-year-old female complained of the right sternoclavicular joint and back pain accompanied limited activities and cutaneous lesions. Laboratory assays revealed abnormal inflammatory factors. Multiple imaging studies illustrated bone lesions and pathological fractures of vertebral bodies. A diagnosis of SAPHO syndrome was made. The patient was treated with Compound Troxerutin and Poreine Cerebroside Injection, non-steroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, corticosteroids and the thoracolumbar brace. The patient was followed up for 6 months and showed improved results.

CONCLUSIONS

The case supports that multiple image inspections and laboratory tests contribute to diagnose SAPHO syndrome, and combination therapies of Compound Troxerutin and Poreine Cerebroside Injection, NSAIDs, bisphosphonates, corticosteroids and the thoracolumbar brace in the treatment of SAPHO syndrome with pathological fractures of vertebral bodies are crucial to regain health.

Authors+Show Affiliations

Department of Orthopedics, the Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China. Jilin provincial Changbai mountain medicine anti-tumor engineering center, Jilin, People's Republic of China.Department of Orthopedics, the Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China. Jilin provincial Changbai mountain medicine anti-tumor engineering center, Jilin, People's Republic of China.Department of Stomatology, the Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China. Jilin provincial Changbai mountain medicine anti-tumor engineering center, Jilin, People's Republic of China.Department of Stomatology, the Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China. luoygjlu@sina.com. Jilin provincial Changbai mountain medicine anti-tumor engineering center, Jilin, People's Republic of China. luoygjlu@sina.com.Life Sciences College, Jilin Agricultural University, Changchun, Jilin, 130118, People's Republic of China. tiancheng@jlau.edu.cn. Jilin provincial Changbai mountain medicine anti-tumor engineering center, Jilin, People's Republic of China. tiancheng@jlau.edu.cn.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30654792

Citation

Li, Yalong, et al. "SAPHO Syndrome With Pathological Fractures of Vertebral Bodies: a Case Report." BMC Musculoskeletal Disorders, vol. 20, no. 1, 2019, p. 27.
Li Y, Liu G, Zhao Y, et al. SAPHO syndrome with pathological fractures of vertebral bodies: a case report. BMC Musculoskelet Disord. 2019;20(1):27.
Li, Y., Liu, G., Zhao, Y., Luo, Y., & Lu, T. (2019). SAPHO syndrome with pathological fractures of vertebral bodies: a case report. BMC Musculoskeletal Disorders, 20(1), p. 27. doi:10.1186/s12891-019-2410-x.
Li Y, et al. SAPHO Syndrome With Pathological Fractures of Vertebral Bodies: a Case Report. BMC Musculoskelet Disord. 2019 Jan 17;20(1):27. PubMed PMID: 30654792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SAPHO syndrome with pathological fractures of vertebral bodies: a case report. AU - Li,Yalong, AU - Liu,Guomin, AU - Zhao,Yian, AU - Luo,Yungang, AU - Lu,Tiancheng, Y1 - 2019/01/17/ PY - 2018/08/04/received PY - 2019/01/08/accepted PY - 2019/1/19/entrez PY - 2019/1/19/pubmed PY - 2019/4/30/medline KW - Bisphosphonates KW - Multiple bone lesions KW - Osteomyelitis KW - SAPHO syndrome KW - Steroids SP - 27 EP - 27 JF - BMC musculoskeletal disorders JO - BMC Musculoskelet Disord VL - 20 IS - 1 N2 - BACKGROUND: It's difficult to diagnose and treat synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome due to its rare and unknown pathogenesis. There is no effective treatment for SAPHO syndrome and the consequences of empirical treatment are unpredictable. This study reports a case of a young female diagnosed as SAPHO syndrome with pathological fractures of vertebral bodies. CASE PRESENTATION: A 29-year-old female complained of the right sternoclavicular joint and back pain accompanied limited activities and cutaneous lesions. Laboratory assays revealed abnormal inflammatory factors. Multiple imaging studies illustrated bone lesions and pathological fractures of vertebral bodies. A diagnosis of SAPHO syndrome was made. The patient was treated with Compound Troxerutin and Poreine Cerebroside Injection, non-steroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, corticosteroids and the thoracolumbar brace. The patient was followed up for 6 months and showed improved results. CONCLUSIONS: The case supports that multiple image inspections and laboratory tests contribute to diagnose SAPHO syndrome, and combination therapies of Compound Troxerutin and Poreine Cerebroside Injection, NSAIDs, bisphosphonates, corticosteroids and the thoracolumbar brace in the treatment of SAPHO syndrome with pathological fractures of vertebral bodies are crucial to regain health. SN - 1471-2474 UR - https://www.unboundmedicine.com/medline/citation/30654792/SAPHO_syndrome_with_pathological_fractures_of_vertebral_bodies:_a_case_report L2 - https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-019-2410-x DB - PRIME DP - Unbound Medicine ER -