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Renal effects of leukotrienes C4 and D4 in anesthetized dogs.
Jpn J Pharmacol. 1988 Jul; 47(3):293-300.JJ

Abstract

We investigated the effects of leukotrienes (LTs) C4 and D4 on renal function and hemodynamics of dogs. LTC4 (0.5 microgram/min, infused into the renal artery), but not LTD4 (1 microgram/min), caused an increase in renal blood flow, urine flow, urinary excretion of sodium and potassium, and rate of free water reabsorption, with a concomitant rise in systemic blood pressure. Intrarenal infusion of LTC4 under conditions of constant renal perfusion pressure induced no significant effect on renal blood flow or urine formation. Infusions or LTC4 and LTD4 into the renal artery induced no change in the release of prostaglandins, PGE2, PGF2 alpha, 6-keto-PGF1 alpha or thromboxane B2 into renal venous blood. From these findings, we concluded that the renal effects of LTC4 were secondary responses to a rise in systemic blood pressure.

Authors+Show Affiliations

Department of Pharmacology, Kagawa Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3065552

Citation

Fukui, K, et al. "Renal Effects of Leukotrienes C4 and D4 in Anesthetized Dogs." Japanese Journal of Pharmacology, vol. 47, no. 3, 1988, pp. 293-300.
Fukui K, Okahara T, Tamaki T, et al. Renal effects of leukotrienes C4 and D4 in anesthetized dogs. Jpn J Pharmacol. 1988;47(3):293-300.
Fukui, K., Okahara, T., Tamaki, T., Fujioka, S., Iwao, H., & Abe, Y. (1988). Renal effects of leukotrienes C4 and D4 in anesthetized dogs. Japanese Journal of Pharmacology, 47(3), 293-300.
Fukui K, et al. Renal Effects of Leukotrienes C4 and D4 in Anesthetized Dogs. Jpn J Pharmacol. 1988;47(3):293-300. PubMed PMID: 3065552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal effects of leukotrienes C4 and D4 in anesthetized dogs. AU - Fukui,K, AU - Okahara,T, AU - Tamaki,T, AU - Fujioka,S, AU - Iwao,H, AU - Abe,Y, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 293 EP - 300 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 47 IS - 3 N2 - We investigated the effects of leukotrienes (LTs) C4 and D4 on renal function and hemodynamics of dogs. LTC4 (0.5 microgram/min, infused into the renal artery), but not LTD4 (1 microgram/min), caused an increase in renal blood flow, urine flow, urinary excretion of sodium and potassium, and rate of free water reabsorption, with a concomitant rise in systemic blood pressure. Intrarenal infusion of LTC4 under conditions of constant renal perfusion pressure induced no significant effect on renal blood flow or urine formation. Infusions or LTC4 and LTD4 into the renal artery induced no change in the release of prostaglandins, PGE2, PGF2 alpha, 6-keto-PGF1 alpha or thromboxane B2 into renal venous blood. From these findings, we concluded that the renal effects of LTC4 were secondary responses to a rise in systemic blood pressure. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/3065552/Renal_effects_of_leukotrienes_C4_and_D4_in_anesthetized_dogs_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/47.293?from=PubMed DB - PRIME DP - Unbound Medicine ER -