Tags

Type your tag names separated by a space and hit enter

Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.
Psychopharmacology (Berl). 2019 Jan; 236(1):111-132.P

Abstract

Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts.

Links

PMC Free PDF

Authors+Show Affiliations

Cahill EN
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK.
Milton AL
Department of Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK. alm46@cam.ac.uk. Behavioural and Clinical Neuroscience Institute, Cambridge, CB2 3EB, UK. alm46@cam.ac.uk.

MeSH

AnimalsConditioning, PsychologicalExtinction, PsychologicalFearHumansMemoryReceptors, DopamineReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30656364

Citation

Cahill, Emma N., and Amy L. Milton. "Neurochemical and Molecular Mechanisms Underlying the Retrieval-extinction Effect." Psychopharmacology, vol. 236, no. 1, 2019, pp. 111-132.
Cahill EN, Milton AL. Neurochemical and molecular mechanisms underlying the retrieval-extinction effect. Psychopharmacology (Berl). 2019;236(1):111-132.
Cahill, E. N., & Milton, A. L. (2019). Neurochemical and molecular mechanisms underlying the retrieval-extinction effect. Psychopharmacology, 236(1), 111-132. https://doi.org/10.1007/s00213-018-5121-3
Cahill EN, Milton AL. Neurochemical and Molecular Mechanisms Underlying the Retrieval-extinction Effect. Psychopharmacology (Berl). 2019;236(1):111-132. PubMed PMID: 30656364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurochemical and molecular mechanisms underlying the retrieval-extinction effect. AU - Cahill,Emma N, AU - Milton,Amy L, Y1 - 2019/01/17/ PY - 2018/07/28/received PY - 2018/11/12/accepted PY - 2019/1/19/pubmed PY - 2019/4/4/medline PY - 2019/1/19/entrez KW - Behaviour KW - Extinction KW - Memory KW - Reconsolidation KW - Retrieval-Extinction SP - 111 EP - 132 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 236 IS - 1 N2 - Extinction within the reconsolidation window, or 'retrieval-extinction', has received much research interest as a possible technique for targeting the reconsolidation of maladaptive memories with a behavioural intervention. However, it remains to be determined whether the retrieval-extinction effect-a long-term reduction in fear behaviour, which appears resistant to spontaneous recovery, renewal and reinstatement-depends specifically on destabilisation of the original memory (the 'reconsolidation-update' account) or represents facilitation of an extinction memory (the 'extinction-facilitation' account). We propose that comparing the neurotransmitter systems, receptors and intracellular signalling pathways recruited by reconsolidation, extinction and retrieval-extinction will provide a way of distinguishing between these accounts. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/30656364/Neurochemical_and_molecular_mechanisms_underlying_the_retrieval_extinction_effect_ DB - PRIME DP - Unbound Medicine ER -