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Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats.
Antiinflamm Antiallergy Agents Med Chem. 2020; 19(2):113-127.AA

Abstract

OBJECTIVE

A number of natural polymer-based drug delivery systems targeting the colon are reported for different applications. Most of the research is based on the class of natural polymers such as polysaccharides. This study compares the anti-inflammatory effect of different polysaccharide based tablets on IBD when a drug carrier is targeted to the colon as matrix and coated systems.

METHODS

The TNBS induced IBD Wistar rats were used as a model for the study. The microscopic and macroscopic parameters were studied in detail. Almost all the important IBD parameters were reported in this work.

RESULTS

The results demonstrated that the polysaccharides are efficient in carrying the drugs to the colon. Reduction in the level of ulcer index (UI), Myeloperoxidase (MPO), and Malondialdehyde MDA, confirmed the inhibitory activity on the development of Reactive oxygen species (ROS). The increased level of Tumor necrosis factor (TNFα) an expression of colonic inducible nitric oxide synthase (iNOS) was lowered in treatments as compared to TNBS control.

CONCLUSION

The different polymer-based mesalamine (DPBM) confirmed the efficient anti- inflammatory activity on IBD induced rats. The increased level of glutathione (GSH), and superoxide dismutase (SOD) also confirmed the effective anti-inflammatory effect. A significant decrease in the ulcer score and ulcer area was reported. The investigation revealed that chitosan is superior to pectin in IBD treatment likewise polysaccharide-based matrix systems are superior to the coated system.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Newton AMJ
Jawaharlal Nehru Technological University, Hyderabad, India. Swift School of Pharmacy, Rajpura, Punjab, India.
Lakshmanan P
Asia Metropolitan University, Selangor, Malaysia.

MeSH

AnimalsAnti-Inflammatory AgentsChitosanColonDisease Models, AnimalDrug Delivery SystemsHumansInflammatory Bowel DiseasesMesalaminePectinsRatsRats, WistarReactive Oxygen SpeciesTrinitrobenzenesulfonic AcidUlcer

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30657050

Citation

Newton, Amaldoss M J., and Prabakaran Lakshmanan. "Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems On TNBS-induced IBD Model Rats." Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, vol. 19, no. 2, 2020, pp. 113-127.
Newton AMJ, Lakshmanan P. Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats. Antiinflamm Antiallergy Agents Med Chem. 2020;19(2):113-127.
Newton, A. M. J., & Lakshmanan, P. (2020). Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats. Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 19(2), 113-127. https://doi.org/10.2174/1871523018666190118112230
Newton AMJ, Lakshmanan P. Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems On TNBS-induced IBD Model Rats. Antiinflamm Antiallergy Agents Med Chem. 2020;19(2):113-127. PubMed PMID: 30657050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats. AU - Newton,Amaldoss M J, AU - Lakshmanan,Prabakaran, PY - 2018/11/13/received PY - 2019/01/04/revised PY - 2019/01/09/accepted PY - 2019/1/19/pubmed PY - 2021/1/23/medline PY - 2019/1/19/entrez KW - Chitosan KW - IBD KW - MDA KW - MPO KW - SOD KW - TNBS KW - TNF α KW - pectin. SP - 113 EP - 127 JF - Anti-inflammatory & anti-allergy agents in medicinal chemistry JO - Antiinflamm Antiallergy Agents Med Chem VL - 19 IS - 2 N2 - OBJECTIVE: A number of natural polymer-based drug delivery systems targeting the colon are reported for different applications. Most of the research is based on the class of natural polymers such as polysaccharides. This study compares the anti-inflammatory effect of different polysaccharide based tablets on IBD when a drug carrier is targeted to the colon as matrix and coated systems. METHODS: The TNBS induced IBD Wistar rats were used as a model for the study. The microscopic and macroscopic parameters were studied in detail. Almost all the important IBD parameters were reported in this work. RESULTS: The results demonstrated that the polysaccharides are efficient in carrying the drugs to the colon. Reduction in the level of ulcer index (UI), Myeloperoxidase (MPO), and Malondialdehyde MDA, confirmed the inhibitory activity on the development of Reactive oxygen species (ROS). The increased level of Tumor necrosis factor (TNFα) an expression of colonic inducible nitric oxide synthase (iNOS) was lowered in treatments as compared to TNBS control. CONCLUSION: The different polymer-based mesalamine (DPBM) confirmed the efficient anti- inflammatory activity on IBD induced rats. The increased level of glutathione (GSH), and superoxide dismutase (SOD) also confirmed the effective anti-inflammatory effect. A significant decrease in the ulcer score and ulcer area was reported. The investigation revealed that chitosan is superior to pectin in IBD treatment likewise polysaccharide-based matrix systems are superior to the coated system. SN - 1875-614X UR - https://www.unboundmedicine.com/medline/citation/30657050/Comparative_Efficacy_of_Chitosan_Pectin_Based_Mesalamine_Colon_Targeted_Drug_Delivery_Systems_on_TNBS_induced_IBD_Model_Rats_ DB - PRIME DP - Unbound Medicine ER -