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Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats.
Gen Physiol Biophys. 2019 Jan; 38(1):63-71.GP

Abstract

Melatonin, the pineal gland hormone, plays a crucial role in regulation of neuroendocrine and defensive functions, free radicals neutralization, and suppresses angiogenesis, proliferation and cancer. The purpose of designing our study is to assess the effect of estradiol benzoate and its combination with melatonin on uteri of female albino rats. For 4 weeks, the present study was conducted on thirty six female rats separated into 3 groups: Control group (rats received the vehicle), EB group (rats were treated by estradiol benzoate (600 μg/kg intramuscular) for induction of endometrial hyperplasia), and EB+Mel group (rats were treated with estradiol benzoate (600 μg/kg) plus melatonin (50 µg/ml) added to drinking water. Melatonin administration reduced estradiol benzoate-induced endometrial hyperplasia and prevented the occurrence of atypia associated with a significant reduction in lipid peroxide level and NF-κB mRNA and a significant rise in immune-expression of caspase-3, interleukin-2 (IL-2) mRNA and total antioxidant levels in uterine tissues. The results demonstrated that melatonin reduced estradiol benzoate action on the endometrium.

Authors+Show Affiliations

Medical Physiology Department, Faculty of Medicine, Minia University, Minia, Egypt. heba_physiology@yahoo.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30657459

Citation

Abdel-Hamid, Heba A., et al. "Melatonin Reduced Endometrial Hyperplasia Induced By Estradiol in Female Albino Rats." General Physiology and Biophysics, vol. 38, no. 1, 2019, pp. 63-71.
Abdel-Hamid HA, Zenhom NM, Toni ND. Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats. Gen Physiol Biophys. 2019;38(1):63-71.
Abdel-Hamid, H. A., Zenhom, N. M., & Toni, N. D. (2019). Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats. General Physiology and Biophysics, 38(1), 63-71. https://doi.org/10.4149/gpb_2018035
Abdel-Hamid HA, Zenhom NM, Toni ND. Melatonin Reduced Endometrial Hyperplasia Induced By Estradiol in Female Albino Rats. Gen Physiol Biophys. 2019;38(1):63-71. PubMed PMID: 30657459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats. AU - Abdel-Hamid,Heba A, AU - Zenhom,Nagwa M, AU - Toni,Nisreen Dm, Y1 - 2019/01/18/ PY - 2018/05/11/received PY - 2018/08/30/accepted PY - 2019/1/19/pubmed PY - 2019/9/11/medline PY - 2019/1/19/entrez SP - 63 EP - 71 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 38 IS - 1 N2 - Melatonin, the pineal gland hormone, plays a crucial role in regulation of neuroendocrine and defensive functions, free radicals neutralization, and suppresses angiogenesis, proliferation and cancer. The purpose of designing our study is to assess the effect of estradiol benzoate and its combination with melatonin on uteri of female albino rats. For 4 weeks, the present study was conducted on thirty six female rats separated into 3 groups: Control group (rats received the vehicle), EB group (rats were treated by estradiol benzoate (600 μg/kg intramuscular) for induction of endometrial hyperplasia), and EB+Mel group (rats were treated with estradiol benzoate (600 μg/kg) plus melatonin (50 µg/ml) added to drinking water. Melatonin administration reduced estradiol benzoate-induced endometrial hyperplasia and prevented the occurrence of atypia associated with a significant reduction in lipid peroxide level and NF-κB mRNA and a significant rise in immune-expression of caspase-3, interleukin-2 (IL-2) mRNA and total antioxidant levels in uterine tissues. The results demonstrated that melatonin reduced estradiol benzoate action on the endometrium. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/30657459/Melatonin_reduced_endometrial_hyperplasia_induced_by_estradiol_in_female_albino_rats_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=GPB&file=2019_01_63.pdf DB - PRIME DP - Unbound Medicine ER -