Tags

Type your tag names separated by a space and hit enter

Association between non-alcoholic fatty liver disease and risk of atrial fibrillation in adult individuals: An updated meta-analysis.
Liver Int. 2019 04; 39(4):758-769.LI

Abstract

BACKGROUND & AIMS

Recent studies examined the association between non-alcoholic fatty liver disease (NAFLD) and risk of atrial fibrillation (AF) in adults, but the findings have been inconsistent. We provided a quantitative estimate of the magnitude of the association between NAFLD and risk of AF.

METHODS

We searched publication databases using predefined keywords to identify observational studies (published up to December 14, 2018), in which NAFLD was diagnosed by biopsy, imaging or biochemistry and AF was diagnosed by medical history and electrocardiograms. Data from selected studies were extracted and meta-analysis was performed using random-effects modelling.

RESULTS

Nine cross-sectional and longitudinal studies were included in the final analysis (n = 364 919 individuals). Meta-analysis of data from 5 cross-sectional studies showed that NAFLD was associated with an increased risk of prevalent AF (random-effects odds ratio 2.07, 95% CI 1.38-3.10; I2 = 54.7%), independent of age, sex, body mass index, hypertension and other common AF risk factors. This risk was particularly high among patients with established diabetes (n = 1 study; random-effects odds ratio 5.17, 95% CI 2.05-13.02). Meta-analysis of data from 4 longitudinal studies showed that NAFLD was independently associated with a 10-year increased risk of incident AF only in type 2 diabetic patients (n = 1 study; random-effects hazard ratio 4.96, 95% CI 1.42-17.28). Sensitivity analyses did not modify these findings. Funnel plots did not reveal significant publication bias.

CONCLUSIONS

NAFLD is associated with an increased risk of AF in middle-aged and elderly individuals (especially in those with type 2 diabetes). However, the observational design of the eligible studies does not allow for proving causality.

Authors+Show Affiliations

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Division of Cardiology, ''IRCCS Sacro Cuore - Don Calabria'' Hospital, Negrar (VR), Italy.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.Department of Internal Medicine I, Gastroenterology, Hepatology & Metabolism, Medical University Innsbruck, Innsbruck, Austria.Nutrition and Metabolism, University of Southampton, Southampton, UK. Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

30657626

Citation

Mantovani, Alessandro, et al. "Association Between Non-alcoholic Fatty Liver Disease and Risk of Atrial Fibrillation in Adult Individuals: an Updated Meta-analysis." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 39, no. 4, 2019, pp. 758-769.
Mantovani A, Dauriz M, Sandri D, et al. Association between non-alcoholic fatty liver disease and risk of atrial fibrillation in adult individuals: An updated meta-analysis. Liver Int. 2019;39(4):758-769.
Mantovani, A., Dauriz, M., Sandri, D., Bonapace, S., Zoppini, G., Tilg, H., Byrne, C. D., & Targher, G. (2019). Association between non-alcoholic fatty liver disease and risk of atrial fibrillation in adult individuals: An updated meta-analysis. Liver International : Official Journal of the International Association for the Study of the Liver, 39(4), 758-769. https://doi.org/10.1111/liv.14044
Mantovani A, et al. Association Between Non-alcoholic Fatty Liver Disease and Risk of Atrial Fibrillation in Adult Individuals: an Updated Meta-analysis. Liver Int. 2019;39(4):758-769. PubMed PMID: 30657626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between non-alcoholic fatty liver disease and risk of atrial fibrillation in adult individuals: An updated meta-analysis. AU - Mantovani,Alessandro, AU - Dauriz,Marco, AU - Sandri,Damiano, AU - Bonapace,Stefano, AU - Zoppini,Giacomo, AU - Tilg,Herbert, AU - Byrne,Christopher D, AU - Targher,Giovanni, Y1 - 2019/02/07/ PY - 2018/12/21/received PY - 2019/01/03/revised PY - 2019/01/09/accepted PY - 2019/1/19/pubmed PY - 2020/5/13/medline PY - 2019/1/19/entrez KW - arrhythmias KW - atrial fibrillation KW - fatty liver KW - meta-analysis SP - 758 EP - 769 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 39 IS - 4 N2 - BACKGROUND & AIMS: Recent studies examined the association between non-alcoholic fatty liver disease (NAFLD) and risk of atrial fibrillation (AF) in adults, but the findings have been inconsistent. We provided a quantitative estimate of the magnitude of the association between NAFLD and risk of AF. METHODS: We searched publication databases using predefined keywords to identify observational studies (published up to December 14, 2018), in which NAFLD was diagnosed by biopsy, imaging or biochemistry and AF was diagnosed by medical history and electrocardiograms. Data from selected studies were extracted and meta-analysis was performed using random-effects modelling. RESULTS: Nine cross-sectional and longitudinal studies were included in the final analysis (n = 364 919 individuals). Meta-analysis of data from 5 cross-sectional studies showed that NAFLD was associated with an increased risk of prevalent AF (random-effects odds ratio 2.07, 95% CI 1.38-3.10; I2 = 54.7%), independent of age, sex, body mass index, hypertension and other common AF risk factors. This risk was particularly high among patients with established diabetes (n = 1 study; random-effects odds ratio 5.17, 95% CI 2.05-13.02). Meta-analysis of data from 4 longitudinal studies showed that NAFLD was independently associated with a 10-year increased risk of incident AF only in type 2 diabetic patients (n = 1 study; random-effects hazard ratio 4.96, 95% CI 1.42-17.28). Sensitivity analyses did not modify these findings. Funnel plots did not reveal significant publication bias. CONCLUSIONS: NAFLD is associated with an increased risk of AF in middle-aged and elderly individuals (especially in those with type 2 diabetes). However, the observational design of the eligible studies does not allow for proving causality. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/30657626/Association_between_non_alcoholic_fatty_liver_disease_and_risk_of_atrial_fibrillation_in_adult_individuals:_An_updated_meta_analysis_ L2 - https://doi.org/10.1111/liv.14044 DB - PRIME DP - Unbound Medicine ER -