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Apolipoprotein E gene in physiological and pathological aging.
Mech Ageing Dev 2019; 178:41-45MA

Abstract

INTRODUCTION

The genetic background plays a role on longevity. The distribution of the apolipoprotein E gene (APOE) variants (ε2, ε3, ε4) may differ across age groups, especially in the oldest old and despite geographical and ethnic specificities. Since the ε4 variant is associated with Alzheimer's disease (AD), it might represent an opportunity for exploring the relationship of APOE with physiological and pathological aging.

AIM

To explore the role played by APOE genotype/alleles on physiological and pathological brain aging.

MATERIALS AND METHODS

The study was conducted in a cohort of centenarians (n = 106), and two cohorts of octogenarians (without cognitive decline, n = 351 controls; and with AD, n = 294).

RESULTS

No significant differences in genotype/allele distributions were observed comparing controls to centenarians. The prevalence of ε2/ε3, ε3/ε3, ε3/ε4 and ε4/ε4 genotypes were significantly different in centenarians compared to AD. The prevalence of ε2 and ε3 alleles were significantly higher in centenarians, whereas the ε4 was less frequent. The ε4 allele was positively associated with AD, whereas a negative association was found for ε2 and ε3 alleles.

CONCLUSIONS

Our study indicates that ε4 allele is strongly associated with AD. APOE significantly affects AD risk, but apparently not longevity.

Authors+Show Affiliations

Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Electronic address: evelyn.ferri@guest.unimi.it.Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address: cristina.gussago@unimi.it.Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Electronic address: martina.casati@unimi.it.Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address: daniela.mari@unimi.it.Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Electronic address: paolo.rossi@policlinico.mi.it.Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Electronic address: simona.ciccone@policlinico.mi.it.Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address: matteo.cesari@unimi.it.Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy. Electronic address: beatrice.arosio@unimi.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30658061

Citation

Ferri, E, et al. "Apolipoprotein E Gene in Physiological and Pathological Aging." Mechanisms of Ageing and Development, vol. 178, 2019, pp. 41-45.
Ferri E, Gussago C, Casati M, et al. Apolipoprotein E gene in physiological and pathological aging. Mech Ageing Dev. 2019;178:41-45.
Ferri, E., Gussago, C., Casati, M., Mari, D., Rossi, P. D., Ciccone, S., ... Arosio, B. (2019). Apolipoprotein E gene in physiological and pathological aging. Mechanisms of Ageing and Development, 178, pp. 41-45. doi:10.1016/j.mad.2019.01.005.
Ferri E, et al. Apolipoprotein E Gene in Physiological and Pathological Aging. Mech Ageing Dev. 2019;178:41-45. PubMed PMID: 30658061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene in physiological and pathological aging. AU - Ferri,E, AU - Gussago,C, AU - Casati,M, AU - Mari,D, AU - Rossi,P D, AU - Ciccone,S, AU - Cesari,M, AU - Arosio,B, Y1 - 2019/01/15/ PY - 2018/10/30/received PY - 2019/01/02/revised PY - 2019/01/15/accepted PY - 2019/1/19/pubmed PY - 2019/6/8/medline PY - 2019/1/19/entrez KW - Alzheimer’s disease KW - Apolipoprotein E KW - Centenarians KW - Longevity SP - 41 EP - 45 JF - Mechanisms of ageing and development JO - Mech. Ageing Dev. VL - 178 N2 - INTRODUCTION: The genetic background plays a role on longevity. The distribution of the apolipoprotein E gene (APOE) variants (ε2, ε3, ε4) may differ across age groups, especially in the oldest old and despite geographical and ethnic specificities. Since the ε4 variant is associated with Alzheimer's disease (AD), it might represent an opportunity for exploring the relationship of APOE with physiological and pathological aging. AIM: To explore the role played by APOE genotype/alleles on physiological and pathological brain aging. MATERIALS AND METHODS: The study was conducted in a cohort of centenarians (n = 106), and two cohorts of octogenarians (without cognitive decline, n = 351 controls; and with AD, n = 294). RESULTS: No significant differences in genotype/allele distributions were observed comparing controls to centenarians. The prevalence of ε2/ε3, ε3/ε3, ε3/ε4 and ε4/ε4 genotypes were significantly different in centenarians compared to AD. The prevalence of ε2 and ε3 alleles were significantly higher in centenarians, whereas the ε4 was less frequent. The ε4 allele was positively associated with AD, whereas a negative association was found for ε2 and ε3 alleles. CONCLUSIONS: Our study indicates that ε4 allele is strongly associated with AD. APOE significantly affects AD risk, but apparently not longevity. SN - 1872-6216 UR - https://www.unboundmedicine.com/medline/citation/30658061/Apolipoprotein_E_gene_in_physiological_and_pathological_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047-6374(18)30219-7 DB - PRIME DP - Unbound Medicine ER -