Citation
Yang, Shiwei, et al. "Comparison of Outcomes of Frontline Immunosuppressive Therapy and Frontline Haploidentical Hematopoietic Stem Cell Transplantation for Children With Severe Aplastic Anemia Who Lack an HLA-Matched Sibling Donor." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, vol. 25, no. 5, 2019, pp. 975-980.
Yang S, Yuan X, Ma R, et al. Comparison of Outcomes of Frontline Immunosuppressive Therapy and Frontline Haploidentical Hematopoietic Stem Cell Transplantation for Children with Severe Aplastic Anemia Who Lack an HLA-Matched Sibling Donor. Biol Blood Marrow Transplant. 2019;25(5):975-980.
Yang, S., Yuan, X., Ma, R., Jiang, L., Guo, J., Zang, Y., Shi, J., Yang, J., Lei, P., Liu, Z., Zhang, Y., & Zhu, Z. (2019). Comparison of Outcomes of Frontline Immunosuppressive Therapy and Frontline Haploidentical Hematopoietic Stem Cell Transplantation for Children with Severe Aplastic Anemia Who Lack an HLA-Matched Sibling Donor. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 25(5), 975-980. https://doi.org/10.1016/j.bbmt.2019.01.017
Yang S, et al. Comparison of Outcomes of Frontline Immunosuppressive Therapy and Frontline Haploidentical Hematopoietic Stem Cell Transplantation for Children With Severe Aplastic Anemia Who Lack an HLA-Matched Sibling Donor. Biol Blood Marrow Transplant. 2019;25(5):975-980. PubMed PMID: 30658223.
TY - JOUR
T1 - Comparison of Outcomes of Frontline Immunosuppressive Therapy and Frontline Haploidentical Hematopoietic Stem Cell Transplantation for Children with Severe Aplastic Anemia Who Lack an HLA-Matched Sibling Donor.
AU - Yang,Shiwei,
AU - Yuan,Xiaoli,
AU - Ma,Rongjun,
AU - Jiang,Li,
AU - Guo,Jianmin,
AU - Zang,Yuzhu,
AU - Shi,Jie,
AU - Yang,Jing,
AU - Lei,Pingchong,
AU - Liu,Zhongwen,
AU - Zhang,Yin,
AU - Zhu,Zunmin,
Y1 - 2019/01/15/
PY - 2018/10/10/received
PY - 2019/01/09/accepted
PY - 2019/1/19/pubmed
PY - 2020/3/21/medline
PY - 2019/1/19/entrez
KW - Haploidentical transplantation
KW - Hematopoietic stem cell
KW - IST
KW - Severe aplastic anemia
SP - 975
EP - 980
JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
JO - Biol Blood Marrow Transplant
VL - 25
IS - 5
N2 - We compared the outcomes of immunosuppressive therapy (IST) with those of T cell-replete haploidentical donor hematopoietic stem cell transplantation (haplo-HSCT) in children and adolescents with severe aplastic anemia (SAA). The medical records of 49 patients with SAA who received frontline IST (n = 29) or frontline haplo-HSCT (n = 20) between 2012 and 2016 were analyzed retrospectively. Fourteen patients responded after the first IST, and 1 patient responded after the second IST in the frontline IST group; 12 patients underwent salvage HSCT after IST failure. Sixteen of the 20 patients who underwent frontline haplo-HSCT survived without treatment failure. The 3-year overall survival of the frontline IST group was comparable to that of the frontline haplo-HSCT group (79.3 ± 7.5% versus 85.0 ± 8.0%; χ2 = 0.110; P = .740). The 3-year failure-free survival was lower in the frontline IST group compared with the frontline haplo-HSCT group (35.9 ± 10.9% versus 80.0 ± 8.9%; χ2 = 4.089; P = .043). Five patients of the IST group who underwent salvage HSCT achieved long survival without event. The event-free survival was lower in the salvage HSCT group compared with the haplo-HSCT group (41.7 ± 14.2% versus 80.0 ± 8.9%; χ2 = 3.992; P = .046), and the incidences of acute GVHD, grade II-IV acute GVHD, chronic GVHD, and severe infection were comparable between the 2 groups. Our results suggest that frontline haplo-HSCT may be a better treatment than IST for children and adolescents with SAA who lack an HLA age-matched familial donor.
SN - 1523-6536
UR - https://www.unboundmedicine.com/medline/citation/30658223/Comparison_of_Outcomes_of_Frontline_Immunosuppressive_Therapy_and_Frontline_Haploidentical_Hematopoietic_Stem_Cell_Transplantation_for_Children_with_Severe_Aplastic_Anemia_Who_Lack_an_HLA_Matched_Sibling_Donor_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1083-8791(19)30066-7
DB - PRIME
DP - Unbound Medicine
ER -