TY - JOUR T1 - Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity. AU - Altieri,Fabio, AU - Cairone,Francesco, AU - Giamogante,Flavia, AU - Carradori,Simone, AU - Locatelli,Marcello, AU - Chichiarelli,Silvia, AU - Cesa,Stefania, Y1 - 2019/01/17/ PY - 2018/12/27/received PY - 2019/01/09/revised PY - 2019/01/14/accepted PY - 2019/1/20/entrez PY - 2019/1/20/pubmed PY - 2019/3/15/medline KW - HPLC-DAD KW - PDIA3 KW - ellagic acid KW - pomegranate KW - punicalagin KW - redox activity JF - Nutrients JO - Nutrients VL - 11 IS - 1 N2 - Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid, play a role as anti-atherogenic and neuroprotective molecules in the complex fighting against the degenerative diseases. The aim of this work was to evaluate the composition in punicalagins and ellagic acid of differently obtained extracts from whole fruit, peels and juices, prepared by squeezing or by centrifugation, of pomegranate belonging to different cultivars. Moreover, a wider phenolic fingerprint was also determined. The bioactivity of the extracts was tested on the redox activity of PDIA3 disulfide isomerase, an enzyme involved in the regulation of several cellular functions and associated with different diseases such as cancer, prion disorders, Alzheimer's and Parkinson's diseases. The results demonstrate that the different ratios between punicalagin and ellagic acid modulate the enzyme activity and other ellagitannins could interfere with this activity. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30658391/Influence_of_Ellagitannins_Extracted_by_Pomegranate_Fruit_on_Disulfide_Isomerase_PDIA3_Activity_ DB - PRIME DP - Unbound Medicine ER -