Tags

Type your tag names separated by a space and hit enter

Dietary intake of fatty acids and its relationship with FEV1/FVC in patients with chronic obstructive pulmonary disease.
Clin Nutr ESPEN. 2019 02; 29:92-96.CN

Abstract

BACKGROUND & AIMS

The deterioration of pulmonary function has been associated with increased levels of systemic inflammation that can be stimulated by consumption of saturated fatty acids and trans fats. We hypothesized that fatty acids intake impact on pulmonary function. However, evidence about the impact of different types of fatty acids on pulmonary function in patients with chronic obstructive pulmonary disease (COPD) is limited and heterogeneous. The aim of this study was to evaluate the association between intake of fatty acids and pulmonary function in patients with COPD.

METHODS

Cross sectional study of patients diagnosed with COPD. The relationship between consumption of fatty acids and the FEV1/FVC ratio obtained by spirometry was assessed. Patients with exacerbations during the prior 2 months, diagnosis of asthma or administration of a dietary supplement were excluded.

RESULTS

A simple linear regression showed that for each gram of carbohydrates and total l fatty acids intake, the FEV1/FVC ratio decreased -0.03 ml (β: -0.03, 95% CI -0.06 to -0.01, p = 0.008) and -0.009 ml (β: -0.00, 95% CI -0.02 to 0.00, p = 0.031) respectively. Pentadecanoic acid (C15:0) was associated with an increase of 0.47 ml in the FEV1/FVC ratio for each milligram intake (β: 0.47, 95% CI 0.04 to 0.91, p = 0.031). Subsequently, when adjusted for calories intake, an increase of 0.53 ml was observed in the FEV1/FVC for each milligram of C15:0 fatty acid intake (β:0.53, 95% CI 0.09 to 0.97, p = 0.018).

CONCLUSION

A positive association was observed between pentadecanoic acid and the FEV1/FVC ratio with a beneficial effect on patients with COPD.

Authors+Show Affiliations

Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: abriljimenezc7@gmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: giselledavilasaid@hotmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: oreatart@gmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: gzz.dulce@gmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: marceelizondo19@gmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: memo_karey@hotmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: mieshe@comcast.net.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: drluisfc@gmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: leslie_vendrell@hotmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: ana_judo@hotmail.com.Heart Failure and Respiratory Distress Clinic at Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico. Electronic address: rnsanchezs@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30661707

Citation

Jiménez-Cepeda, Abril, et al. "Dietary Intake of Fatty Acids and Its Relationship With FEV1/FVC in Patients With Chronic Obstructive Pulmonary Disease." Clinical Nutrition ESPEN, vol. 29, 2019, pp. 92-96.
Jiménez-Cepeda A, Dávila-Said G, Orea-Tejeda A, et al. Dietary intake of fatty acids and its relationship with FEV1/FVC in patients with chronic obstructive pulmonary disease. Clin Nutr ESPEN. 2019;29:92-96.
Jiménez-Cepeda, A., Dávila-Said, G., Orea-Tejeda, A., González-Islas, D., Elizondo-Montes, M., Pérez-Cortes, G., Keirns-Davies, C., Castillo-Aguilar, L. F., Verdeja-Vendrell, L., Peláez-Hernández, V., & Sánchez-Santillán, R. N. (2019). Dietary intake of fatty acids and its relationship with FEV1/FVC in patients with chronic obstructive pulmonary disease. Clinical Nutrition ESPEN, 29, 92-96. https://doi.org/10.1016/j.clnesp.2018.11.015
Jiménez-Cepeda A, et al. Dietary Intake of Fatty Acids and Its Relationship With FEV1/FVC in Patients With Chronic Obstructive Pulmonary Disease. Clin Nutr ESPEN. 2019;29:92-96. PubMed PMID: 30661707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of fatty acids and its relationship with FEV1/FVC in patients with chronic obstructive pulmonary disease. AU - Jiménez-Cepeda,Abril, AU - Dávila-Said,Giselle, AU - Orea-Tejeda,Arturo, AU - González-Islas,Dulce, AU - Elizondo-Montes,Marcela, AU - Pérez-Cortes,Guillermo, AU - Keirns-Davies,Candace, AU - Castillo-Aguilar,Luis Felipe, AU - Verdeja-Vendrell,Leslie, AU - Peláez-Hernández,Viridiana, AU - Sánchez-Santillán,Rocío Nayelí, Y1 - 2018/12/08/ PY - 2018/06/26/received PY - 2018/11/08/revised PY - 2018/11/26/accepted PY - 2019/1/22/entrez PY - 2019/1/22/pubmed PY - 2020/4/14/medline KW - Chronic obstructive pulmonary disease KW - Fatty acids KW - Nutrient intake KW - Pulmonary function KW - Saturated fatty acids SP - 92 EP - 96 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 29 N2 - BACKGROUND & AIMS: The deterioration of pulmonary function has been associated with increased levels of systemic inflammation that can be stimulated by consumption of saturated fatty acids and trans fats. We hypothesized that fatty acids intake impact on pulmonary function. However, evidence about the impact of different types of fatty acids on pulmonary function in patients with chronic obstructive pulmonary disease (COPD) is limited and heterogeneous. The aim of this study was to evaluate the association between intake of fatty acids and pulmonary function in patients with COPD. METHODS: Cross sectional study of patients diagnosed with COPD. The relationship between consumption of fatty acids and the FEV1/FVC ratio obtained by spirometry was assessed. Patients with exacerbations during the prior 2 months, diagnosis of asthma or administration of a dietary supplement were excluded. RESULTS: A simple linear regression showed that for each gram of carbohydrates and total l fatty acids intake, the FEV1/FVC ratio decreased -0.03 ml (β: -0.03, 95% CI -0.06 to -0.01, p = 0.008) and -0.009 ml (β: -0.00, 95% CI -0.02 to 0.00, p = 0.031) respectively. Pentadecanoic acid (C15:0) was associated with an increase of 0.47 ml in the FEV1/FVC ratio for each milligram intake (β: 0.47, 95% CI 0.04 to 0.91, p = 0.031). Subsequently, when adjusted for calories intake, an increase of 0.53 ml was observed in the FEV1/FVC for each milligram of C15:0 fatty acid intake (β:0.53, 95% CI 0.09 to 0.97, p = 0.018). CONCLUSION: A positive association was observed between pentadecanoic acid and the FEV1/FVC ratio with a beneficial effect on patients with COPD. SN - 2405-4577 UR - https://www.unboundmedicine.com/medline/citation/30661707/Dietary_intake_of_fatty_acids_and_its_relationship_with_FEV1/FVC_in_patients_with_chronic_obstructive_pulmonary_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-4577(18)30370-X DB - PRIME DP - Unbound Medicine ER -