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Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases.
J Cutan Pathol. 2019 May; 46(5):305-309.JC

Abstract

BACKGROUND

Epidermolytic acanthoma (EA) is a rare, benign acquired cutaneous keratosis displaying epidermolytic hyperkeratosis in more than 50% of its surface. Because of the sparsity of comprehensive studies, little is known on the patient demographics and clinical characteristics of this uncommon entity. We wish to comprehensively characterize the clinical and demographic features of EA and to differentiate it from its mimickers.

METHODS

We carried out a retrospective review of 131 cases of EA, recorded clinical and histopathologic features and performed linear regression of yearly incidence rates to assess for possible under-reporting of this entity.

RESULTS

EA affected both genders equally. We found 9.08 cases per 100 000 biopsy specimens per year and linear regression analysis showed significantly decreasing incidence rates. Analysis of the anatomical site distribution of EA lesions showed a more frequent genital location in men (39.1% of cases in men, as compared to 11.3% for women). Contrary to previous studies, lesions were most frequently single (91.7%) and the mean age of presentation was 57.8 years.

CONCLUSION

The presented largest case series to-date indicates that EA is probably an underdiagnosed entity and establishes the demographic and clinical features of EA.

Authors+Show Affiliations

Department of Pathology, University of Montréal, Montréal, Canada.Division of Dermatology, University of Ottawa, Ottawa, Canada.Department of Dermatology, Yale University School of Medicine, New Haven, CT. Department of Genetics, Yale University School of Medicine, New Haven, CT. Department of Pathology, Yale University School of Medicine, New Haven, CT.Department of Dermatology, Yale University School of Medicine, New Haven, CT. Department of Pathology, Yale University School of Medicine, New Haven, CT.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30663082

Citation

Roy, Simon F., et al. "Solitary and Multiple Epidermolytic Acanthoma: a Demographic and Clinical Study of 131 Cases." Journal of Cutaneous Pathology, vol. 46, no. 5, 2019, pp. 305-309.
Roy SF, Ghazawi FM, Choate KA, et al. Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. J Cutan Pathol. 2019;46(5):305-309.
Roy, S. F., Ghazawi, F. M., Choate, K. A., & McNiff, J. M. (2019). Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. Journal of Cutaneous Pathology, 46(5), 305-309. https://doi.org/10.1111/cup.13422
Roy SF, et al. Solitary and Multiple Epidermolytic Acanthoma: a Demographic and Clinical Study of 131 Cases. J Cutan Pathol. 2019;46(5):305-309. PubMed PMID: 30663082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. AU - Roy,Simon F, AU - Ghazawi,Feras M, AU - Choate,Keith A, AU - McNiff,Jennifer M, Y1 - 2019/02/08/ PY - 2018/12/12/received PY - 2019/01/10/revised PY - 2019/01/14/accepted PY - 2019/1/22/pubmed PY - 2019/8/14/medline PY - 2019/1/22/entrez KW - benign keratoses KW - epidemiology of epidermolytic acanthoma KW - epidermolytic acanthoma KW - epidermolytic hyperkeratosis KW - incidence SP - 305 EP - 309 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 46 IS - 5 N2 - BACKGROUND: Epidermolytic acanthoma (EA) is a rare, benign acquired cutaneous keratosis displaying epidermolytic hyperkeratosis in more than 50% of its surface. Because of the sparsity of comprehensive studies, little is known on the patient demographics and clinical characteristics of this uncommon entity. We wish to comprehensively characterize the clinical and demographic features of EA and to differentiate it from its mimickers. METHODS: We carried out a retrospective review of 131 cases of EA, recorded clinical and histopathologic features and performed linear regression of yearly incidence rates to assess for possible under-reporting of this entity. RESULTS: EA affected both genders equally. We found 9.08 cases per 100 000 biopsy specimens per year and linear regression analysis showed significantly decreasing incidence rates. Analysis of the anatomical site distribution of EA lesions showed a more frequent genital location in men (39.1% of cases in men, as compared to 11.3% for women). Contrary to previous studies, lesions were most frequently single (91.7%) and the mean age of presentation was 57.8 years. CONCLUSION: The presented largest case series to-date indicates that EA is probably an underdiagnosed entity and establishes the demographic and clinical features of EA. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/30663082/Solitary_and_multiple_epidermolytic_acanthoma:_A_demographic_and_clinical_study_of_131_cases_ L2 - https://doi.org/10.1111/cup.13422 DB - PRIME DP - Unbound Medicine ER -