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New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases.
J Cell Biochem. 2019 06; 120(6):8908-8918.JC

Abstract

Neurodegenerative diseases (NDs) are a diversity of neurological disorders characterized by the progressive degeneration of the structure and function of the central nervous system (CNS). The most common NDs are Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Recently, many studies have investigated associations between common NDs with noncoding RNAs (ncRNAs) molecules. ncRNAs are regulatory molecules in the normal functioning of the CNS. Two of the most important ncRNAs are microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). These types of ncRNAs are involved in different biological processes including brain development, maturation, differentiation, neuronal cell specification, neurogenesis, and neurotransmission. Increasing data has demonstrated that miRNAs and lncRNAs have strong correlations with the development of NDs, particularly gene expression. Besides, ncRNAs can be introduced as new biomarkers for diagnosis and prognosis of NDs. Hence, in this review, we summarized the involvement of various miRNAs and lncRNAs in most common NDs followed by a correlation of ncRNAs dysregulation with the AD, PD, and HD.

Authors+Show Affiliations

Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.Department of English, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30663117

Citation

Maniati, Mohammad Saeed, et al. "New Insights Into the Role of microRNAs and Long Noncoding RNAs in Most Common Neurodegenerative Diseases." Journal of Cellular Biochemistry, vol. 120, no. 6, 2019, pp. 8908-8918.
Maniati MS, Maniati M, Yousefi T, et al. New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases. J Cell Biochem. 2019;120(6):8908-8918.
Maniati, M. S., Maniati, M., Yousefi, T., Ahmadi-Ahangar, A., & Tehrani, S. S. (2019). New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases. Journal of Cellular Biochemistry, 120(6), 8908-8918. https://doi.org/10.1002/jcb.28361
Maniati MS, et al. New Insights Into the Role of microRNAs and Long Noncoding RNAs in Most Common Neurodegenerative Diseases. J Cell Biochem. 2019;120(6):8908-8918. PubMed PMID: 30663117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases. AU - Maniati,Mohammad Saeed, AU - Maniati,Mahmood, AU - Yousefi,Tooba, AU - Ahmadi-Ahangar,Alijan, AU - Tehrani,Sadra Samavarchi, Y1 - 2019/01/20/ PY - 2018/10/23/received PY - 2018/11/29/accepted PY - 2019/1/22/pubmed PY - 2020/7/22/medline PY - 2019/1/22/entrez KW - biomarker KW - long noncoding RNA KW - microRNA KW - neurodegenerative disease SP - 8908 EP - 8918 JF - Journal of cellular biochemistry JO - J Cell Biochem VL - 120 IS - 6 N2 - Neurodegenerative diseases (NDs) are a diversity of neurological disorders characterized by the progressive degeneration of the structure and function of the central nervous system (CNS). The most common NDs are Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Recently, many studies have investigated associations between common NDs with noncoding RNAs (ncRNAs) molecules. ncRNAs are regulatory molecules in the normal functioning of the CNS. Two of the most important ncRNAs are microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). These types of ncRNAs are involved in different biological processes including brain development, maturation, differentiation, neuronal cell specification, neurogenesis, and neurotransmission. Increasing data has demonstrated that miRNAs and lncRNAs have strong correlations with the development of NDs, particularly gene expression. Besides, ncRNAs can be introduced as new biomarkers for diagnosis and prognosis of NDs. Hence, in this review, we summarized the involvement of various miRNAs and lncRNAs in most common NDs followed by a correlation of ncRNAs dysregulation with the AD, PD, and HD. SN - 1097-4644 UR - https://www.unboundmedicine.com/medline/citation/30663117/New_insights_into_the_role_of_microRNAs_and_long_noncoding_RNAs_in_most_common_neurodegenerative_diseases_ DB - PRIME DP - Unbound Medicine ER -