Tags

Type your tag names separated by a space and hit enter

IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis.
Int Immunopharmacol. 2019 Apr; 69:27-33.II

Abstract

Allergic rhinitis (AR) is a common upper airway allergic disease caused by allergens triggering a type 2 immune response. The imbalance of CD4+ T cell subsets is the essential immunological feature of AR, which is mainly characterized by the predominance of T helper (Th) 2 cells. Recent studies indicated that the anti-inflammatory factor interleukin (IL)-37 is involved in the immune regulation of AR. However, the mechanism of IL-37 acts on AR has not been fully elucidated. Thus, we sought to assess the protective role of IL-37 in AR and further explore the possible mechanism. An ovalbumin (OVA)-induced AR murine model was established. After IL-37 treatment, the allergic symptoms (sneezes and nasal rubbings), nasal mucosal infiltration with eosinophils, and serum IgE production were found significantly attenuated. For CD4+ T cell subsets, the proliferation and differentiation of Th2 and Th17 cells were restrained. The relevant effector cytokines of IL-4, IL-5, IL-6, and IL-17a protein expression and transcription factors GATA3 and RORγt mRNA levels were obviously decreased. However, IL-37 had no significant effect on Th1 and Treg response including in IFN-γ, IL-10, T-bet, and Foxp3 expression. Furthermore, IL-37 was found down-regulated the STAT6, STAT3, phospho-STAT6, and phospho-STAT3 expression. In conclusion, IL-37 alleviates allergic inflammation in AR possibly through repressing STAT6 and STAT3 signaling pathways.

Authors+Show Affiliations

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.Department of Otorhinolaryngology, Dazhou Central Hospital, Dazhou, Sichuan, People's Republic of China.Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China.Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China. Electronic address: hghcq@sina.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30665041

Citation

Wang, Jue, et al. "IL-37 Attenuates Allergic Process Via STAT6/STAT3 Pathways in Murine Allergic Rhinitis." International Immunopharmacology, vol. 69, 2019, pp. 27-33.
Wang J, Shen Y, Li C, et al. IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis. Int Immunopharmacol. 2019;69:27-33.
Wang, J., Shen, Y., Li, C., Liu, C., Wang, Z. H., Li, Y. S., Ke, X., & Hu, G. H. (2019). IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis. International Immunopharmacology, 69, 27-33. https://doi.org/10.1016/j.intimp.2019.01.013
Wang J, et al. IL-37 Attenuates Allergic Process Via STAT6/STAT3 Pathways in Murine Allergic Rhinitis. Int Immunopharmacol. 2019;69:27-33. PubMed PMID: 30665041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis. AU - Wang,Jue, AU - Shen,Yang, AU - Li,Cong, AU - Liu,Chuan, AU - Wang,Zhi-Hai, AU - Li,Yan-Shi, AU - Ke,Xia, AU - Hu,Guo-Hua, Y1 - 2019/01/18/ PY - 2018/11/23/received PY - 2019/01/06/revised PY - 2019/01/08/accepted PY - 2019/1/22/pubmed PY - 2019/7/19/medline PY - 2019/1/22/entrez KW - Allergic rhinitis KW - Interleukin-37 KW - STAT3 KW - STAT6 KW - Th17 KW - Th2 SP - 27 EP - 33 JF - International immunopharmacology JO - Int. Immunopharmacol. VL - 69 N2 - Allergic rhinitis (AR) is a common upper airway allergic disease caused by allergens triggering a type 2 immune response. The imbalance of CD4+ T cell subsets is the essential immunological feature of AR, which is mainly characterized by the predominance of T helper (Th) 2 cells. Recent studies indicated that the anti-inflammatory factor interleukin (IL)-37 is involved in the immune regulation of AR. However, the mechanism of IL-37 acts on AR has not been fully elucidated. Thus, we sought to assess the protective role of IL-37 in AR and further explore the possible mechanism. An ovalbumin (OVA)-induced AR murine model was established. After IL-37 treatment, the allergic symptoms (sneezes and nasal rubbings), nasal mucosal infiltration with eosinophils, and serum IgE production were found significantly attenuated. For CD4+ T cell subsets, the proliferation and differentiation of Th2 and Th17 cells were restrained. The relevant effector cytokines of IL-4, IL-5, IL-6, and IL-17a protein expression and transcription factors GATA3 and RORγt mRNA levels were obviously decreased. However, IL-37 had no significant effect on Th1 and Treg response including in IFN-γ, IL-10, T-bet, and Foxp3 expression. Furthermore, IL-37 was found down-regulated the STAT6, STAT3, phospho-STAT6, and phospho-STAT3 expression. In conclusion, IL-37 alleviates allergic inflammation in AR possibly through repressing STAT6 and STAT3 signaling pathways. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/30665041/IL_37_attenuates_allergic_process_via_STAT6/STAT3_pathways_in_murine_allergic_rhinitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(18)31216-5 DB - PRIME DP - Unbound Medicine ER -