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Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017.
Emerg Infect Dis. 2019 02; 25(2):281-289.EI

Abstract

Monkeypox, caused by a zoonotic orthopoxvirus, is endemic in Central and West Africa. Monkeypox has been sporadically reported in the Republic of the Congo. During March 22-April 5, 2017, we investigated 43 suspected human monkeypox cases. We interviewed suspected case-patients and collected dried blood strips and vesicular and crust specimens (active lesions), which we tested for orthopoxvirus antibodies by ELISA and monkeypox virus and varicella zoster virus DNA by PCR. An ecologic investigation was conducted around Manfouété, and specimens from 105 small mammals were tested for anti-orthopoxvirus antibodies or DNA. Among the suspected human cases, 22 met the confirmed, probable, and possible case definitions. Only 18 patients had available dried blood strips; 100% were IgG positive, and 88.9% (16/18) were IgM positive. Among animals, only specimens from Cricetomys giant pouched rats showed presence of orthopoxvirus antibodies, adding evidence to this species' involvement in the transmission and maintenance of monkeypox virus in nature.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

30666937

Citation

Doshi, Reena H., et al. "Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017." Emerging Infectious Diseases, vol. 25, no. 2, 2019, pp. 281-289.
Doshi RH, Guagliardo SAJ, Doty JB, et al. Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. Emerg Infect Dis. 2019;25(2):281-289.
Doshi, R. H., Guagliardo, S. A. J., Doty, J. B., Babeaux, A. D., Matheny, A., Burgado, J., Townsend, M. B., Morgan, C. N., Satheshkumar, P. S., Ndakala, N., Kanjingankolo, T., Kitembo, L., Malekani, J., Kalemba, L., Pukuta, E., N'kaya, T., Kangoula, F., Moses, C., McCollum, A. M., ... Petersen, B. W. (2019). Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. Emerging Infectious Diseases, 25(2), 281-289. https://doi.org/10.3201/eid2502.181222
Doshi RH, et al. Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. Emerg Infect Dis. 2019;25(2):281-289. PubMed PMID: 30666937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiologic and Ecologic Investigations of Monkeypox, Likouala Department, Republic of the Congo, 2017. AU - Doshi,Reena H, AU - Guagliardo,Sarah Anne J, AU - Doty,Jeffrey B, AU - Babeaux,Angelie Dzabatou, AU - Matheny,Audrey, AU - Burgado,Jillybeth, AU - Townsend,Michael B, AU - Morgan,Clint N, AU - Satheshkumar,Panayampalli Subbian, AU - Ndakala,Nestor, AU - Kanjingankolo,Therese, AU - Kitembo,Lambert, AU - Malekani,Jean, AU - Kalemba,Lem's, AU - Pukuta,Elisabeth, AU - N'kaya,Tobi, AU - Kangoula,Fabien, AU - Moses,Cynthia, AU - McCollum,Andrea M, AU - Reynolds,Mary G, AU - Mombouli,Jean-Vivien, AU - Nakazawa,Yoshinori, AU - Petersen,Brett W, PY - 2019/1/23/entrez PY - 2019/1/23/pubmed PY - 2019/7/30/medline KW - Republic of the Congo KW - ecology KW - epidemiology KW - monkeypox KW - orthopoxvirus KW - viruses KW - zoonoses SP - 281 EP - 289 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 25 IS - 2 N2 - Monkeypox, caused by a zoonotic orthopoxvirus, is endemic in Central and West Africa. Monkeypox has been sporadically reported in the Republic of the Congo. During March 22-April 5, 2017, we investigated 43 suspected human monkeypox cases. We interviewed suspected case-patients and collected dried blood strips and vesicular and crust specimens (active lesions), which we tested for orthopoxvirus antibodies by ELISA and monkeypox virus and varicella zoster virus DNA by PCR. An ecologic investigation was conducted around Manfouété, and specimens from 105 small mammals were tested for anti-orthopoxvirus antibodies or DNA. Among the suspected human cases, 22 met the confirmed, probable, and possible case definitions. Only 18 patients had available dried blood strips; 100% were IgG positive, and 88.9% (16/18) were IgM positive. Among animals, only specimens from Cricetomys giant pouched rats showed presence of orthopoxvirus antibodies, adding evidence to this species' involvement in the transmission and maintenance of monkeypox virus in nature. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/30666937/Epidemiologic_and_Ecologic_Investigations_of_Monkeypox_Likouala_Department_Republic_of_the_Congo_2017_ L2 - https://doi.org/10.3201/eid2502.181222 DB - PRIME DP - Unbound Medicine ER -