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The Many Faces of FKBP51.
Biomolecules. 2019 01 21; 9(1)B

Abstract

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51's physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs.

Authors+Show Affiliations

Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. haehle@drugdiscovery.chemie.tu-darmstadt.de.Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. merz@drugdiscovery.chemie.tu-darmstadt.de.Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. meyners@drugdiscovery.chemie.tu-darmstadt.de.Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, D-64287 Darmstadt, Germany. hausch@drugdiscovery.chemie.tu-darmstadt.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30669684

Citation

Hähle, Andreas, et al. "The Many Faces of FKBP51." Biomolecules, vol. 9, no. 1, 2019.
Hähle A, Merz S, Meyners C, et al. The Many Faces of FKBP51. Biomolecules. 2019;9(1).
Hähle, A., Merz, S., Meyners, C., & Hausch, F. (2019). The Many Faces of FKBP51. Biomolecules, 9(1). https://doi.org/10.3390/biom9010035
Hähle A, et al. The Many Faces of FKBP51. Biomolecules. 2019 01 21;9(1) PubMed PMID: 30669684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Many Faces of FKBP51. AU - Hähle,Andreas, AU - Merz,Stephanie, AU - Meyners,Christian, AU - Hausch,Felix, Y1 - 2019/01/21/ PY - 2018/12/07/received PY - 2019/01/14/revised PY - 2019/01/14/accepted PY - 2019/1/24/entrez PY - 2019/1/24/pubmed PY - 2019/6/14/medline KW - FK506 KW - FKBP51 KW - GR KW - Hsp90 KW - NF-κB KW - SAFit KW - glucocorticoids JF - Biomolecules JO - Biomolecules VL - 9 IS - 1 N2 - The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51's physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/30669684/The_Many_Faces_of_FKBP51_ L2 - https://www.mdpi.com/resolver?pii=biom9010035 DB - PRIME DP - Unbound Medicine ER -