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Evaluation of the antifungal activity of individual and combined monoterpenes against Rhizopus stolonifer and Absidia coerulea.
Environ Sci Pollut Res Int 2019; 26(8):7804-7809ES

Abstract

The development of natural plant extracts and essential oils will help to decrease the negative effects of synthetic chemicals. In the present study, the antifungal activity of individual and combined monoterpenes against Rhizopus stolonifer and Absidia coerulea was evaluated. The results from antifungal tests showed that eugenol, carvacrol, and isoeugenol, among all the tested compounds, exhibited strong antifungal activity against the two tested fungi. Furthermore, carvacrol exhibited the most toxic effects against R. stolonifer and A. coerulea, and the IC50 values of carvacrol for the two fungi were 44.94 μg/ml and 50.83 μg/ml, respectively. The compounds (±)-menthol, b-citronellol, geraniol, 3,7-dimethyl-1-octanol, citral, and cuminaldehyde had only strong antifungal activity against R. stolonifer. In addition, the value of the synergistic co-efficient (SR) of a combination of isoeugenol and eugenol (1:1) showed an additive effect against R. stolonifer. The combination of isoeugenol and cuminaldehyde (1:1) showed an antagonistic effect against A. coerulea. Our results indicated that carvacrol and isoeugenol had potential antifungal effects against the two tested fungi and could be utilized in novel biological fungicide development.

Authors+Show Affiliations

College of Plant Protection, Anhui Agricultural University, Hefei, 230036, People's Republic of China.Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Life Science and Technology, Hubei Engineering University, Xiaogan, 432000, People's Republic of China.Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Life Science and Technology, Hubei Engineering University, Xiaogan, 432000, People's Republic of China.School of Agricultural and Food Science, Zhejiang A & F University, Linan, 311300, People's Republic of China.Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Life Science and Technology, Hubei Engineering University, Xiaogan, 432000, People's Republic of China.Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Life Science and Technology, Hubei Engineering University, Xiaogan, 432000, People's Republic of China.Key Laboratory of Plant Diseases and Insect Pests Control of Hainan, Institute of Plant Protection of Hainan Academy of Agricultural Sciences, Haikou, 571100, People's Republic of China. linzhf123@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30675711

Citation

Zhou, Lijun, et al. "Evaluation of the Antifungal Activity of Individual and Combined Monoterpenes Against Rhizopus Stolonifer and Absidia Coerulea." Environmental Science and Pollution Research International, vol. 26, no. 8, 2019, pp. 7804-7809.
Zhou L, Zhang Z, Wei M, et al. Evaluation of the antifungal activity of individual and combined monoterpenes against Rhizopus stolonifer and Absidia coerulea. Environ Sci Pollut Res Int. 2019;26(8):7804-7809.
Zhou, L., Zhang, Z., Wei, M., Xie, Y., He, S., Shi, H., & Lin, Z. (2019). Evaluation of the antifungal activity of individual and combined monoterpenes against Rhizopus stolonifer and Absidia coerulea. Environmental Science and Pollution Research International, 26(8), pp. 7804-7809. doi:10.1007/s11356-019-04278-z.
Zhou L, et al. Evaluation of the Antifungal Activity of Individual and Combined Monoterpenes Against Rhizopus Stolonifer and Absidia Coerulea. Environ Sci Pollut Res Int. 2019;26(8):7804-7809. PubMed PMID: 30675711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the antifungal activity of individual and combined monoterpenes against Rhizopus stolonifer and Absidia coerulea. AU - Zhou,Lijun, AU - Zhang,Zhilin, AU - Wei,Mi, AU - Xie,Yongjian, AU - He,Shan, AU - Shi,Hongan, AU - Lin,Zhufeng, Y1 - 2019/01/24/ PY - 2018/10/30/received PY - 2019/01/16/accepted PY - 2019/1/25/pubmed PY - 2019/5/7/medline PY - 2019/1/25/entrez KW - Additive effect KW - Antagonistic effect KW - Antifungal activity KW - Carvacrol KW - Cuminaldehyde KW - Isoeugenol SP - 7804 EP - 7809 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 8 N2 - The development of natural plant extracts and essential oils will help to decrease the negative effects of synthetic chemicals. In the present study, the antifungal activity of individual and combined monoterpenes against Rhizopus stolonifer and Absidia coerulea was evaluated. The results from antifungal tests showed that eugenol, carvacrol, and isoeugenol, among all the tested compounds, exhibited strong antifungal activity against the two tested fungi. Furthermore, carvacrol exhibited the most toxic effects against R. stolonifer and A. coerulea, and the IC50 values of carvacrol for the two fungi were 44.94 μg/ml and 50.83 μg/ml, respectively. The compounds (±)-menthol, b-citronellol, geraniol, 3,7-dimethyl-1-octanol, citral, and cuminaldehyde had only strong antifungal activity against R. stolonifer. In addition, the value of the synergistic co-efficient (SR) of a combination of isoeugenol and eugenol (1:1) showed an additive effect against R. stolonifer. The combination of isoeugenol and cuminaldehyde (1:1) showed an antagonistic effect against A. coerulea. Our results indicated that carvacrol and isoeugenol had potential antifungal effects against the two tested fungi and could be utilized in novel biological fungicide development. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/30675711/Evaluation_of_the_antifungal_activity_of_individual_and_combined_monoterpenes_against_Rhizopus_stolonifer_and_Absidia_coerulea L2 - https://dx.doi.org/10.1007/s11356-019-04278-z DB - PRIME DP - Unbound Medicine ER -