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[Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis].
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Jan; 21(1):82-88.ZD

Abstract

OBJECTIVE

To systematically review the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children.

METHODS

RevMan5.3 was used to perform a Meta analysis of randomized controlled trials on the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children published between January 2008 and May 2018 across the world. A subgroup analysis was conducted according to the type of probiotics for intervention, follow-up time, time of probiotic supplementation, and study areas.

RESULTS

A total of 22 articles were selected, with 3 280 cases in the intervention group and 3 281 cases in the control group. The results of pooled effect size showed that probiotic supplementation during pregnancy and/or infancy significantly reduced the incidence rate of atopic dermatitis (RR=0.81, 95%CI: 0.70-0.93, P<0.05). According to the subgroup analysis, the intervention with Lactobacillus and Bifidobacterium had a significant effect (RR=0.68, 95%CI: 0.52-0.90, P<0.05); probiotic supplementation during both pregnancy and infancy also had a significant effect (RR=0.77, 95%CI: 0.66-0.90, P<0.05); probiotic supplementation during pregnancy and/or infancy had a better effect in preventing atopic dermatitis in children aged ≤2 years than in those aged >2 years (RR=0.74, 95%CI: 0.61-0.90, P<0.05); probiotic supplementation had a significant effect in Australia (RR=0.83, 95%CI: 0.73-0.96, P<0.05) and Europe/the United States (RR=0.74, 95%CI: 0.61-0.91, P<0.05). Heterogeneity was mainly due to follow-up time (I2=62.7%) and time of probiotic supplementation (I2=53.5%).

CONCLUSIONS

Probiotic supplementation during pregnancy and infancy helps to prevent atopic dermatitis in children, and mixed Lactobacillus-Bifidobacterium intervention has a better effect.

Authors+Show Affiliations

Community Healthcare Service Center, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518110, China. 1979805961@qq.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

chi

PubMed ID

30675869

Citation

Yin, Dao-Gen, et al. "[Effect of Probiotic Supplementation During Pregnancy and Infancy in Preventing Atopic Dermatitis in Children: a Meta Analysis]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 21, no. 1, 2019, pp. 82-88.
Yin DG, He Z, Duan XY, et al. [Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis]. Zhongguo Dang Dai Er Ke Za Zhi. 2019;21(1):82-88.
Yin, D. G., He, Z., Duan, X. Y., Fan, F. X., Liao, X. B., & Wang, Q. C. (2019). [Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 21(1), 82-88.
Yin DG, et al. [Effect of Probiotic Supplementation During Pregnancy and Infancy in Preventing Atopic Dermatitis in Children: a Meta Analysis]. Zhongguo Dang Dai Er Ke Za Zhi. 2019;21(1):82-88. PubMed PMID: 30675869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis]. AU - Yin,Dao-Gen, AU - He,Zhen, AU - Duan,Xue-Yan, AU - Fan,Fei-Xiang, AU - Liao,Xiao-Bing, AU - Wang,Qing-Chuan, PY - 2019/1/25/entrez PY - 2019/1/25/pubmed PY - 2019/4/10/medline SP - 82 EP - 88 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 21 IS - 1 N2 - OBJECTIVE: To systematically review the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children. METHODS: RevMan5.3 was used to perform a Meta analysis of randomized controlled trials on the effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children published between January 2008 and May 2018 across the world. A subgroup analysis was conducted according to the type of probiotics for intervention, follow-up time, time of probiotic supplementation, and study areas. RESULTS: A total of 22 articles were selected, with 3 280 cases in the intervention group and 3 281 cases in the control group. The results of pooled effect size showed that probiotic supplementation during pregnancy and/or infancy significantly reduced the incidence rate of atopic dermatitis (RR=0.81, 95%CI: 0.70-0.93, P<0.05). According to the subgroup analysis, the intervention with Lactobacillus and Bifidobacterium had a significant effect (RR=0.68, 95%CI: 0.52-0.90, P<0.05); probiotic supplementation during both pregnancy and infancy also had a significant effect (RR=0.77, 95%CI: 0.66-0.90, P<0.05); probiotic supplementation during pregnancy and/or infancy had a better effect in preventing atopic dermatitis in children aged ≤2 years than in those aged >2 years (RR=0.74, 95%CI: 0.61-0.90, P<0.05); probiotic supplementation had a significant effect in Australia (RR=0.83, 95%CI: 0.73-0.96, P<0.05) and Europe/the United States (RR=0.74, 95%CI: 0.61-0.91, P<0.05). Heterogeneity was mainly due to follow-up time (I2=62.7%) and time of probiotic supplementation (I2=53.5%). CONCLUSIONS: Probiotic supplementation during pregnancy and infancy helps to prevent atopic dermatitis in children, and mixed Lactobacillus-Bifidobacterium intervention has a better effect. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/30675869/[Effect_of_probiotic_supplementation_during_pregnancy_and_infancy_in_preventing_atopic_dermatitis_in_children:_a_Meta_analysis]_ L2 - http://www.zgddek.com/EN/abstract/abstract14681shtml DB - PRIME DP - Unbound Medicine ER -