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Major salivary gland enlargement in IgG4-related disease is associated with multiorgan involvement and higher basal disease activity.
Mod Rheumatol 2019; :1-5MR

Abstract

OBJECTIVE

To evaluate if major salivary gland enlargement in patients with IgG4-related disease (IgG4-RD) is associated with systemic involvement.

METHODS

We included 47 patients with diagnosis of IgG4-RD. We retrospectively collected demographics, organ involvement, disease activity and damage assessed by the IgG4-RD Responder Index (IgG4-RD RI) and treatment.

RESULTS

25 patients (53%) were men, mean age 50.8 years and median disease duration 27 months. Most frequently anatomic sites affected were lymph nodes 55%, pancreas 51% and lacrimal glands 43%. We observed major salivary gland involvement in 22 (46.8%) patients. When we compared patients with (n = 22) vs. without (n = 25) salivary gland enlargement, the first group had a higher number of affected organs, a higher prevalence of lacrimal glands, lymph nodes, and lung involvement, rheumatoid factor positivity, azathioprine and prednisone use, as well as a higher baseline IgG4-RD RI and a longer delay in diagnosis. At logistic regression analysis we found an association of major salivary gland enlargement with the basal IgG4-RD RI (OR 1.37, 95%CI 1.09-1.61, p = .001) and with lacrimal gland involvement (OR 34.7, 95%CI 4.6-258, p = .001).

CONCLUSION

Our study highlights the systemic nature of IgG4-RD. Patients with major salivary gland enlargement should be routinely screened for multi-organ disease.

Authors+Show Affiliations

a Department of Immunology and Rheumatology , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City , Mexico.b Department of Pathology , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City , Mexico.a Department of Immunology and Rheumatology , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City , Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30676828

Citation

Martín-Nares, Eduardo, et al. "Major Salivary Gland Enlargement in IgG4-related Disease Is Associated With Multiorgan Involvement and Higher Basal Disease Activity." Modern Rheumatology, 2019, pp. 1-5.
Martín-Nares E, Ángeles-Ángeles A, Hernandez-Molina G. Major salivary gland enlargement in IgG4-related disease is associated with multiorgan involvement and higher basal disease activity. Mod Rheumatol. 2019.
Martín-Nares, E., Ángeles-Ángeles, A., & Hernandez-Molina, G. (2019). Major salivary gland enlargement in IgG4-related disease is associated with multiorgan involvement and higher basal disease activity. Modern Rheumatology, pp. 1-5. doi:10.1080/14397595.2019.1572575.
Martín-Nares E, Ángeles-Ángeles A, Hernandez-Molina G. Major Salivary Gland Enlargement in IgG4-related Disease Is Associated With Multiorgan Involvement and Higher Basal Disease Activity. Mod Rheumatol. 2019 Jan 24;1-5. PubMed PMID: 30676828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Major salivary gland enlargement in IgG4-related disease is associated with multiorgan involvement and higher basal disease activity. AU - Martín-Nares,Eduardo, AU - Ángeles-Ángeles,Arturo, AU - Hernandez-Molina,Gabriela, Y1 - 2019/01/24/ PY - 2019/1/25/pubmed PY - 2019/1/25/medline PY - 2019/1/25/entrez KW - IgG4-RD KW - IgG4-RD RI KW - parotid enlargement SP - 1 EP - 5 JF - Modern rheumatology JO - Mod Rheumatol N2 - OBJECTIVE: To evaluate if major salivary gland enlargement in patients with IgG4-related disease (IgG4-RD) is associated with systemic involvement. METHODS: We included 47 patients with diagnosis of IgG4-RD. We retrospectively collected demographics, organ involvement, disease activity and damage assessed by the IgG4-RD Responder Index (IgG4-RD RI) and treatment. RESULTS: 25 patients (53%) were men, mean age 50.8 years and median disease duration 27 months. Most frequently anatomic sites affected were lymph nodes 55%, pancreas 51% and lacrimal glands 43%. We observed major salivary gland involvement in 22 (46.8%) patients. When we compared patients with (n = 22) vs. without (n = 25) salivary gland enlargement, the first group had a higher number of affected organs, a higher prevalence of lacrimal glands, lymph nodes, and lung involvement, rheumatoid factor positivity, azathioprine and prednisone use, as well as a higher baseline IgG4-RD RI and a longer delay in diagnosis. At logistic regression analysis we found an association of major salivary gland enlargement with the basal IgG4-RD RI (OR 1.37, 95%CI 1.09-1.61, p = .001) and with lacrimal gland involvement (OR 34.7, 95%CI 4.6-258, p = .001). CONCLUSION: Our study highlights the systemic nature of IgG4-RD. Patients with major salivary gland enlargement should be routinely screened for multi-organ disease. SN - 1439-7609 UR - https://www.unboundmedicine.com/medline/citation/30676828/Major_salivary_gland_enlargement_in_IgG4_related_disease_is_associated_with_multiorgan_involvement_and_higher_basal_disease_activity_ L2 - http://www.tandfonline.com/doi/full/10.1080/14397595.2019.1572575 DB - PRIME DP - Unbound Medicine ER -