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BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities.
J Med Food. 2019 Feb; 22(2):140-151.JM

Abstract

The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and peptic ulcer. The gastroprotective effects of BST-104 and its active components were evaluated in rat models of HCl/ethanol-induced gastritis and acetic acid-induced gastric ulcer. After orally administering BST-104, chlorogenic acid, rebamipide (positive control), or vehicle to each animal model, gastric lesion sizes, gastric mucus statuses, proinflammatory cytokine levels, and oxidative stress were measured. Superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels and oxidized/reduced glutathione (GSH) ratios in gastric mucosal tissues were measured to evaluate oxidative stress. To clarify the action mechanism of BST-104, we investigated nuclear factor (NF)-κB pathway involvement by real-time polymerase chain reaction (PCR). In the acetic acid-induced ulcer model, oral administration of BST-104 at 50, 100, or 200 mg/kg significantly reduced gastric lesions by 38%, 43%, and 55%, respectively, compared with vehicle controls. BST-104 significantly increased gastric mucus contents and this was accompanied by higher levels of hexosamine, sialic acid, and prostaglandin E2 in gastric mucus. Furthermore, BST-104 treatment increased antioxidant activities, as evidenced by higher levels of catalase, SOD, and oxidized/reduced GSH and lower MDA levels. In addition, BST-104 significantly suppressed proinflammatory cytokine (tumor necrosis factor-α, interleukin [IL]-6, and IL-1β) increases, and real-time PCR showed that BST-104 significantly downregulated NF-κB expression. In summary, BST-104 and its active component, chlorogenic acid, were found to have gastroprotective effects by virtue of their antioxidant and anti-inflammatory properties through downregulation of NF-κB expression.

Authors+Show Affiliations

1 Division of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea.2 Department of Biology Education, Korea National University of Education, Cheongju, South Korea.1 Division of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea.1 Division of Gastroenterology, Department of Internal Medicine, Inha University College of Medicine, Incheon, South Korea.3 Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam, South Korea.3 Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam, South Korea.3 Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30676853

Citation

Bang, Byoung Wook, et al. "BST-104, a Water Extract of Lonicera Japonica, Has a Gastroprotective Effect Via Antioxidant and Anti-Inflammatory Activities." Journal of Medicinal Food, vol. 22, no. 2, 2019, pp. 140-151.
Bang BW, Park D, Kwon KS, et al. BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities. J Med Food. 2019;22(2):140-151.
Bang, B. W., Park, D., Kwon, K. S., Lee, D. H., Jang, M. J., Park, S. K., & Kim, J. Y. (2019). BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities. Journal of Medicinal Food, 22(2), 140-151. https://doi.org/10.1089/jmf.2018.4231
Bang BW, et al. BST-104, a Water Extract of Lonicera Japonica, Has a Gastroprotective Effect Via Antioxidant and Anti-Inflammatory Activities. J Med Food. 2019;22(2):140-151. PubMed PMID: 30676853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities. AU - Bang,Byoung Wook, AU - Park,Dongsun, AU - Kwon,Kye Sook, AU - Lee,Don Haeng, AU - Jang,Min-Jung, AU - Park,Sun Kyu, AU - Kim,Jeom-Yong, Y1 - 2019/01/24/ PY - 2019/1/25/pubmed PY - 2019/5/22/medline PY - 2019/1/25/entrez KW - SP - 140 EP - 151 JF - Journal of medicinal food JO - J Med Food VL - 22 IS - 2 N2 - The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and peptic ulcer. The gastroprotective effects of BST-104 and its active components were evaluated in rat models of HCl/ethanol-induced gastritis and acetic acid-induced gastric ulcer. After orally administering BST-104, chlorogenic acid, rebamipide (positive control), or vehicle to each animal model, gastric lesion sizes, gastric mucus statuses, proinflammatory cytokine levels, and oxidative stress were measured. Superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels and oxidized/reduced glutathione (GSH) ratios in gastric mucosal tissues were measured to evaluate oxidative stress. To clarify the action mechanism of BST-104, we investigated nuclear factor (NF)-κB pathway involvement by real-time polymerase chain reaction (PCR). In the acetic acid-induced ulcer model, oral administration of BST-104 at 50, 100, or 200 mg/kg significantly reduced gastric lesions by 38%, 43%, and 55%, respectively, compared with vehicle controls. BST-104 significantly increased gastric mucus contents and this was accompanied by higher levels of hexosamine, sialic acid, and prostaglandin E2 in gastric mucus. Furthermore, BST-104 treatment increased antioxidant activities, as evidenced by higher levels of catalase, SOD, and oxidized/reduced GSH and lower MDA levels. In addition, BST-104 significantly suppressed proinflammatory cytokine (tumor necrosis factor-α, interleukin [IL]-6, and IL-1β) increases, and real-time PCR showed that BST-104 significantly downregulated NF-κB expression. In summary, BST-104 and its active component, chlorogenic acid, were found to have gastroprotective effects by virtue of their antioxidant and anti-inflammatory properties through downregulation of NF-κB expression. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/30676853/BST_104_a_Water_Extract_of_Lonicera_japonica_Has_a_Gastroprotective_Effect_via_Antioxidant_and_Anti_Inflammatory_Activities_ L2 - https://www.liebertpub.com/doi/10.1089/jmf.2018.4231?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -