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Tetra-proline-modified calix[4]arene-bonded silica stationary phase for simultaneous reversed-phase/hydrophilic interaction mixed-mode chromatography.
J Sep Sci 2019; 42(7):1374-1383JS

Abstract

A new water-soluble tetra-proline-modified calix[4]arene-bonded silica stationary phase was prepared straightforwardly by an indirect method and characterized by elemental analysis, energy dispersive Spectrometry, solid-state 13 C NMR spectroscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. Due to the simultaneous introduction of polar tetra-proline and nonpolar calix[4]arene, the developed column possessing a double retention mode of reverse-phase liquid chromatography and hydrophilic interaction liquid chromatography. A series of hydrophobic and hydrophilic test samples, including nucleosides and nucleotides, amines, monosubstituted benzenes, chiral compounds, and phenols, were used to evaluate the developed stationary phase. A rapid separation capability, high separation efficiency, and selectivity were achieved based on the multiple interactions between solutes and tetra-proline-modified calix[4]arene-bonded silica stationary phase. Moreover, the developed stationary phase was further used to detect and separate hexamethylenetetramine in rice flour. All the results indicated the potential merits of the developed stationary phase for simultaneous separation of complex hydrophobic and hydrophilic samples with high selectivity.

Authors+Show Affiliations

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.Center for Advanced Analysis and Computational Science, Zhengzhou University, Zhengzhou, P. R. China.College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30677234

Citation

Zhang, Wenfen, et al. "Tetra-proline-modified Calix[4]arene-bonded Silica Stationary Phase for Simultaneous Reversed-phase/hydrophilic Interaction Mixed-mode Chromatography." Journal of Separation Science, vol. 42, no. 7, 2019, pp. 1374-1383.
Zhang W, Zhang Y, Zhang G, et al. Tetra-proline-modified calix[4]arene-bonded silica stationary phase for simultaneous reversed-phase/hydrophilic interaction mixed-mode chromatography. J Sep Sci. 2019;42(7):1374-1383.
Zhang, W., Zhang, Y., Zhang, G., Ba, X., Xia, S., Zhao, W., ... Zhang, S. (2019). Tetra-proline-modified calix[4]arene-bonded silica stationary phase for simultaneous reversed-phase/hydrophilic interaction mixed-mode chromatography. Journal of Separation Science, 42(7), pp. 1374-1383. doi:10.1002/jssc.201800967.
Zhang W, et al. Tetra-proline-modified Calix[4]arene-bonded Silica Stationary Phase for Simultaneous Reversed-phase/hydrophilic Interaction Mixed-mode Chromatography. J Sep Sci. 2019;42(7):1374-1383. PubMed PMID: 30677234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tetra-proline-modified calix[4]arene-bonded silica stationary phase for simultaneous reversed-phase/hydrophilic interaction mixed-mode chromatography. AU - Zhang,Wenfen, AU - Zhang,Yongming, AU - Zhang,Guangrui, AU - Ba,Xin, AU - Xia,Shaige, AU - Zhao,Wuduo, AU - Yin,Dan, AU - Zhang,Shusheng, Y1 - 2019/02/11/ PY - 2018/09/18/received PY - 2018/12/25/revised PY - 2019/01/16/accepted PY - 2019/1/25/pubmed PY - 2019/7/19/medline PY - 2019/1/25/entrez KW - hydrophilic interaction liquid chromatography KW - mixed-mode retention KW - reversed-phase liquid chromatography KW - stationary phases SP - 1374 EP - 1383 JF - Journal of separation science JO - J Sep Sci VL - 42 IS - 7 N2 - A new water-soluble tetra-proline-modified calix[4]arene-bonded silica stationary phase was prepared straightforwardly by an indirect method and characterized by elemental analysis, energy dispersive Spectrometry, solid-state 13 C NMR spectroscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. Due to the simultaneous introduction of polar tetra-proline and nonpolar calix[4]arene, the developed column possessing a double retention mode of reverse-phase liquid chromatography and hydrophilic interaction liquid chromatography. A series of hydrophobic and hydrophilic test samples, including nucleosides and nucleotides, amines, monosubstituted benzenes, chiral compounds, and phenols, were used to evaluate the developed stationary phase. A rapid separation capability, high separation efficiency, and selectivity were achieved based on the multiple interactions between solutes and tetra-proline-modified calix[4]arene-bonded silica stationary phase. Moreover, the developed stationary phase was further used to detect and separate hexamethylenetetramine in rice flour. All the results indicated the potential merits of the developed stationary phase for simultaneous separation of complex hydrophobic and hydrophilic samples with high selectivity. SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/30677234/Tetra_proline_modified_calix[4]arene_bonded_silica_stationary_phase_for_simultaneous_reversed_phase/hydrophilic_interaction_mixed_mode_chromatography_ L2 - https://doi.org/10.1002/jssc.201800967 DB - PRIME DP - Unbound Medicine ER -