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Nodular amyloidosis in a patient with systemic scleroderma.
Dermatol Online J. 2018 Sep 15; 24(9)DO

Abstract

Primary cutaneous amyloidosis may be characterized as macular amyloidosis, lichenoid amyloidosis, or nodular amyloidosis. Nodular amyloidosis results from the deposition of immunoglobulin light chains and may rarely be associated with systemic amyloidosis. We report an unusual case of a patient with systemic scleroderma who developed primary cutaneous nodular amyloidosis on the left lower leg. The diagnosis was confirmed with a skin biopsy with Congo red staining and a novel technique using a laser microdissection and mass spectrometry-based proteomic analysis method for amyloid protein characterization. A work-up for systemic amyloidosis was negative and the patient improved symptomatically with wound care. Patients with primary cutaneous nodular amyloidosis should be followed clinically over time for the possible development of systemic amyloidosis, although the risk of disease progression is likely low.

Authors+Show Affiliations

Duke University Medical Center, Department of Dermatology, Durham, North Carolina. Anne.marano@duke.edu.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30677833

Citation

Marano, Anne L., et al. "Nodular Amyloidosis in a Patient With Systemic Scleroderma." Dermatology Online Journal, vol. 24, no. 9, 2018.
Marano AL, Selim MA, Cardones AR, et al. Nodular amyloidosis in a patient with systemic scleroderma. Dermatol Online J. 2018;24(9).
Marano, A. L., Selim, M. A., Cardones, A. R., & Burton, C. S. (2018). Nodular amyloidosis in a patient with systemic scleroderma. Dermatology Online Journal, 24(9).
Marano AL, et al. Nodular Amyloidosis in a Patient With Systemic Scleroderma. Dermatol Online J. 2018 Sep 15;24(9) PubMed PMID: 30677833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nodular amyloidosis in a patient with systemic scleroderma. AU - Marano,Anne L, AU - Selim,M Angelica, AU - Cardones,Adela R, AU - Burton,Claude S, Y1 - 2018/09/15/ PY - 2018/10/24/received PY - 2018/10/24/accepted PY - 2019/1/26/entrez PY - 2019/1/27/pubmed PY - 2019/5/15/medline JF - Dermatology online journal JO - Dermatol. Online J. VL - 24 IS - 9 N2 - Primary cutaneous amyloidosis may be characterized as macular amyloidosis, lichenoid amyloidosis, or nodular amyloidosis. Nodular amyloidosis results from the deposition of immunoglobulin light chains and may rarely be associated with systemic amyloidosis. We report an unusual case of a patient with systemic scleroderma who developed primary cutaneous nodular amyloidosis on the left lower leg. The diagnosis was confirmed with a skin biopsy with Congo red staining and a novel technique using a laser microdissection and mass spectrometry-based proteomic analysis method for amyloid protein characterization. A work-up for systemic amyloidosis was negative and the patient improved symptomatically with wound care. Patients with primary cutaneous nodular amyloidosis should be followed clinically over time for the possible development of systemic amyloidosis, although the risk of disease progression is likely low. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/30677833/Nodular_amyloidosis_in_a_patient_with_systemic_scleroderma_ L2 - http://escholarship.org/uc/item/85b030dk DB - PRIME DP - Unbound Medicine ER -