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Electrophysiological determinants of the clinical severity of axonal peripheral neuropathy.
Muscle Nerve. 2019 04; 59(4):491-493.MN

Abstract

INTRODUCTION

Electrophysiological diagnosis of axonal peripheral neuropathy (PN) is based on the attenuated amplitudes of nerve conduction studies (NCS), or a reduced sural/radial amplitude ratio (SRAR). We aimed to identify the electrophysiological determinants of the clinical severity of PN.

METHODS

Patients with chronic axonal PN underwent detailed NCS. The clinical severity of PN was determined based upon the overall neuropathy limitations scale (ONLS).

RESULTS

Ninety-five patients (71.6% males, mean age 71.9 ± 9.0 years) were recruited. Significant correlations were observed between the radial sensory nerve action potential (SNAP) and the ONLS total score (Spearman's rho -0.382, p < 0.001); and between the tibial compound muscle action potential and the ONLS leg score (Spearman's rho -0.283, p = 0.005). No correlations between the SRAR and the ONLS scores were found.

DISCUSSION

The radial SNAP is the strongest electrophysiological determinant of PN severity and might be useful for monitoring disease progression or response to treatment. Muscle Nerve 59:491-493, 2019.

Authors+Show Affiliations

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust.Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust.Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust.Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30680742

Citation

Zis, Panagiotis, et al. "Electrophysiological Determinants of the Clinical Severity of Axonal Peripheral Neuropathy." Muscle & Nerve, vol. 59, no. 4, 2019, pp. 491-493.
Zis P, Hadjivassiliou M, Rao DG, et al. Electrophysiological determinants of the clinical severity of axonal peripheral neuropathy. Muscle Nerve. 2019;59(4):491-493.
Zis, P., Hadjivassiliou, M., Rao, D. G., & Sarrigiannis, P. G. (2019). Electrophysiological determinants of the clinical severity of axonal peripheral neuropathy. Muscle & Nerve, 59(4), 491-493. https://doi.org/10.1002/mus.26425
Zis P, et al. Electrophysiological Determinants of the Clinical Severity of Axonal Peripheral Neuropathy. Muscle Nerve. 2019;59(4):491-493. PubMed PMID: 30680742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiological determinants of the clinical severity of axonal peripheral neuropathy. AU - Zis,Panagiotis, AU - Hadjivassiliou,Marios, AU - Rao,Dasappaiah Ganesh, AU - Sarrigiannis,Ptolemaios Georgios, Y1 - 2019/02/11/ PY - 2018/03/20/received PY - 2019/01/15/revised PY - 2019/01/19/accepted PY - 2019/1/27/pubmed PY - 2019/7/6/medline PY - 2019/1/26/entrez KW - SRAR KW - electrodiagnostic KW - polyneuropathy KW - radial nerve KW - scale KW - severity SP - 491 EP - 493 JF - Muscle & nerve JO - Muscle Nerve VL - 59 IS - 4 N2 - INTRODUCTION: Electrophysiological diagnosis of axonal peripheral neuropathy (PN) is based on the attenuated amplitudes of nerve conduction studies (NCS), or a reduced sural/radial amplitude ratio (SRAR). We aimed to identify the electrophysiological determinants of the clinical severity of PN. METHODS: Patients with chronic axonal PN underwent detailed NCS. The clinical severity of PN was determined based upon the overall neuropathy limitations scale (ONLS). RESULTS: Ninety-five patients (71.6% males, mean age 71.9 ± 9.0 years) were recruited. Significant correlations were observed between the radial sensory nerve action potential (SNAP) and the ONLS total score (Spearman's rho -0.382, p < 0.001); and between the tibial compound muscle action potential and the ONLS leg score (Spearman's rho -0.283, p = 0.005). No correlations between the SRAR and the ONLS scores were found. DISCUSSION: The radial SNAP is the strongest electrophysiological determinant of PN severity and might be useful for monitoring disease progression or response to treatment. Muscle Nerve 59:491-493, 2019. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/30680742/Electrophysiological_determinants_of_the_clinical_severity_of_axonal_peripheral_neuropathy_ L2 - https://doi.org/10.1002/mus.26425 DB - PRIME DP - Unbound Medicine ER -